CA2455843A1 - Compositions d'administration therapeutique et methodes d'utilisation associees - Google Patents
Compositions d'administration therapeutique et methodes d'utilisation associees Download PDFInfo
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- CA2455843A1 CA2455843A1 CA002455843A CA2455843A CA2455843A1 CA 2455843 A1 CA2455843 A1 CA 2455843A1 CA 002455843 A CA002455843 A CA 002455843A CA 2455843 A CA2455843 A CA 2455843A CA 2455843 A1 CA2455843 A1 CA 2455843A1
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- polyoxypropylene
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
L'invention concerne des compositions et des méthodes de traitement des maladies infectieuses et génétiques par thérapie génique ainsi que par administration intracellulaire d'oligonucléotides antisens ou d'autres séquences d'acides nucléiques. L'invention concerne une composition d'administration thérapeutique pouvant traiter un état pathologique. Cette composition contient un mélange d'apport d'une dose efficace d'un composé thérapeutique pouvant modifier la fonction de la séquence d'acides nucléiques, ainsi qu'une dose efficace d'un copolymère bloc représenté par la formule générale (I) ou (II), dans laquelle le poids moléculaire moyen global de la portion de copolymère octabloc représentée par polyoxypropyléne est compris entre environ 5000 et environ 7000 daltons; a représente un nombre tel que la portion représentée par polyoxyéthylène constitue entre environ 10 % et environ 40 % du composé en poids; et b représente un nombre tel que la portion de polyoxypropylène du poids moléculaire total du copolymère octabloc constitue entre environ 60 % et environ 90 % du composé en poids. Par ailleurs, l'invention concerne des compositions et des procédés faisant intervenir des copolymères bloc inverses actifs. Ces copolymères inverses comportent un noyau central de polyoxypropylène (POP) pourvu de part et d'autre de polyoxyéthylène (POE). Ces copolymères bloc inverses sont représentés par la formule (III) dans laquelle <= b >= représente un nombre tel que le poids moléculairede l'hydrophobe (C¿3?H¿6?O)¿b? est compris entre environ 2000 et 20 000, e <= a >= représentant un nombre tel que le pourcentage del'hydrophile (C¿2?H¿4?O)¿a? est compris entre environ 1 et 90 %.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/919,504 US20020123476A1 (en) | 1991-03-19 | 2001-07-31 | Therapeutic delivery compositions and methods of use thereof |
| US09/919,504 | 2001-07-31 | ||
| US09/929,819 US6933286B2 (en) | 1991-03-19 | 2001-08-14 | Therapeutic delivery compositions and methods of use thereof |
| US09/929,819 | 2001-08-14 | ||
| PCT/US2002/024425 WO2003011008A2 (fr) | 2001-07-31 | 2002-07-31 | Compositions d'administration therapeutique et methodes d'utilisation associees |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2455843A1 true CA2455843A1 (fr) | 2003-02-13 |
Family
ID=27129773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002455843A Abandoned CA2455843A1 (fr) | 2001-07-31 | 2002-07-31 | Compositions d'administration therapeutique et methodes d'utilisation associees |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1421170A2 (fr) |
| JP (1) | JP2005500340A (fr) |
| CA (1) | CA2455843A1 (fr) |
| WO (1) | WO2003011008A2 (fr) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5234683A (en) * | 1985-06-18 | 1993-08-10 | Emory University | Method of stimulating the immune system |
| EP0318081B1 (fr) * | 1987-11-27 | 1991-07-24 | Akzo N.V. | Stabilisation d'anticorps |
| US6093391A (en) * | 1992-10-08 | 2000-07-25 | Supratek Pharma, Inc. | Peptide copolymer compositions |
| US5656611A (en) * | 1994-11-18 | 1997-08-12 | Supratek Pharma Inc. | Polynucleotide compositions |
| US6359054B1 (en) * | 1994-11-18 | 2002-03-19 | Supratek Pharma Inc. | Polynucleotide compositions for intramuscular administration |
| US5824322A (en) * | 1995-08-21 | 1998-10-20 | Cytrx Corporation | Compositions and methods for growth promotion |
-
2002
- 2002-07-31 EP EP02765919A patent/EP1421170A2/fr not_active Withdrawn
- 2002-07-31 WO PCT/US2002/024425 patent/WO2003011008A2/fr active Application Filing
- 2002-07-31 CA CA002455843A patent/CA2455843A1/fr not_active Abandoned
- 2002-07-31 JP JP2003516253A patent/JP2005500340A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005500340A (ja) | 2005-01-06 |
| WO2003011008A2 (fr) | 2003-02-13 |
| EP1421170A2 (fr) | 2004-05-26 |
| WO2003011008A3 (fr) | 2004-03-25 |
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