CA2452505A1 - Embolic compositions with non-cyanoacrylate rheology modifying agents - Google Patents
Embolic compositions with non-cyanoacrylate rheology modifying agents Download PDFInfo
- Publication number
- CA2452505A1 CA2452505A1 CA002452505A CA2452505A CA2452505A1 CA 2452505 A1 CA2452505 A1 CA 2452505A1 CA 002452505 A CA002452505 A CA 002452505A CA 2452505 A CA2452505 A CA 2452505A CA 2452505 A1 CA2452505 A1 CA 2452505A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- cyanoacrylate
- modifying agent
- poly
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 204
- 229920001651 Cyanoacrylate Polymers 0.000 title claims abstract description 79
- 238000000518 rheometry Methods 0.000 title claims abstract description 28
- 230000003073 embolic effect Effects 0.000 title claims description 51
- MWCLLHOVUTZFKS-UHFFFAOYSA-N Methyl cyanoacrylate Chemical compound COC(=O)C(=C)C#N MWCLLHOVUTZFKS-UHFFFAOYSA-N 0.000 title claims description 36
- -1 alkyl cyanoacrylate Chemical compound 0.000 claims abstract description 89
- 239000000463 material Substances 0.000 claims abstract description 63
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 54
- 238000000034 method Methods 0.000 claims abstract description 35
- 239000004014 plasticizer Substances 0.000 claims abstract description 30
- 239000003381 stabilizer Substances 0.000 claims abstract description 18
- 239000008280 blood Substances 0.000 claims abstract description 10
- 210000004369 blood Anatomy 0.000 claims abstract description 10
- 239000000178 monomer Substances 0.000 claims description 43
- 229920000642 polymer Polymers 0.000 claims description 42
- 239000002245 particle Substances 0.000 claims description 27
- 206010002329 Aneurysm Diseases 0.000 claims description 16
- 150000001875 compounds Chemical class 0.000 claims description 16
- 230000002792 vascular Effects 0.000 claims description 13
- 239000003921 oil Substances 0.000 claims description 12
- 125000000217 alkyl group Chemical group 0.000 claims description 11
- 239000000725 suspension Substances 0.000 claims description 11
- 125000004432 carbon atom Chemical group C* 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 9
- 239000011236 particulate material Substances 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 9
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- 239000003963 antioxidant agent Substances 0.000 claims description 6
- 235000006708 antioxidants Nutrition 0.000 claims description 6
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims description 6
- 229920001577 copolymer Polymers 0.000 claims description 6
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 150000001242 acetic acid derivatives Chemical class 0.000 claims description 3
- 229910021485 fumed silica Inorganic materials 0.000 claims description 3
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- 150000007524 organic acids Chemical class 0.000 claims description 3
- 229910052697 platinum Inorganic materials 0.000 claims description 3
- 229910052715 tantalum Inorganic materials 0.000 claims description 3
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- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 2
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- 229910000014 Bismuth subcarbonate Inorganic materials 0.000 claims description 2
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- 125000003118 aryl group Chemical group 0.000 claims description 2
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- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 2
- MGLUJXPJRXTKJM-UHFFFAOYSA-L bismuth subcarbonate Chemical compound O=[Bi]OC(=O)O[Bi]=O MGLUJXPJRXTKJM-UHFFFAOYSA-L 0.000 claims description 2
- 229940036358 bismuth subcarbonate Drugs 0.000 claims description 2
- 150000001860 citric acid derivatives Chemical class 0.000 claims description 2
- 238000011049 filling Methods 0.000 claims description 2
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- 229910052740 iodine Inorganic materials 0.000 claims description 2
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- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical class OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 claims description 2
- 229920000728 polyester Polymers 0.000 claims description 2
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- 229910004158 TaO Inorganic materials 0.000 claims 1
- GEIAQOFPUVMAGM-UHFFFAOYSA-N ZrO Inorganic materials [Zr]=O GEIAQOFPUVMAGM-UHFFFAOYSA-N 0.000 claims 1
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- 230000000087 stabilizing effect Effects 0.000 description 9
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 8
- 210000004204 blood vessel Anatomy 0.000 description 8
- MLIREBYILWEBDM-UHFFFAOYSA-N cyanoacetic acid Chemical compound OC(=O)CC#N MLIREBYILWEBDM-UHFFFAOYSA-N 0.000 description 7
- 239000012530 fluid Substances 0.000 description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
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- 238000006243 chemical reaction Methods 0.000 description 5
- 239000007972 injectable composition Substances 0.000 description 5
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 230000006496 vascular abnormality Effects 0.000 description 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
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- 229910000147 aluminium phosphate Inorganic materials 0.000 description 4
- 230000006399 behavior Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 4
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 4
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 208000032843 Hemorrhage Diseases 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 125000005233 alkylalcohol group Chemical group 0.000 description 3
- 230000036770 blood supply Effects 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000003301 hydrolyzing effect Effects 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 239000011800 void material Substances 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
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- 239000000853 adhesive Substances 0.000 description 2
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- 239000004067 bulking agent Substances 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
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- NLCKLZIHJQEMCU-UHFFFAOYSA-N cyano prop-2-enoate Chemical compound C=CC(=O)OC#N NLCKLZIHJQEMCU-UHFFFAOYSA-N 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- JJJFUHOGVZWXNQ-UHFFFAOYSA-N enbucrilate Chemical compound CCCCOC(=O)C(=C)C#N JJJFUHOGVZWXNQ-UHFFFAOYSA-N 0.000 description 2
- 229950010048 enbucrilate Drugs 0.000 description 2
- MMKRHZKQPFCLLS-UHFFFAOYSA-N ethyl myristate Chemical compound CCCCCCCCCCCCCC(=O)OCC MMKRHZKQPFCLLS-UHFFFAOYSA-N 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
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- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
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- 229910052741 iridium Inorganic materials 0.000 description 2
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- 239000011159 matrix material Substances 0.000 description 2
- 230000003387 muscular Effects 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N n-hexadecanoic acid Natural products CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- NWVVVBRKAWDGAB-UHFFFAOYSA-N p-methoxyphenol Chemical compound COC1=CC=C(O)C=C1 NWVVVBRKAWDGAB-UHFFFAOYSA-N 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
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- 239000010936 titanium Substances 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 150000003772 α-tocopherols Chemical class 0.000 description 1
- 235000007680 β-tocopherol Nutrition 0.000 description 1
- 150000003781 β-tocopherols Chemical class 0.000 description 1
- 150000003785 γ-tocopherols Chemical class 0.000 description 1
- 150000003789 δ-tocopherols Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
- C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
- C08F20/10—Esters
- C08F20/26—Esters containing oxygen in addition to the carboxy oxygen
- C08F20/32—Esters containing oxygen in addition to the carboxy oxygen containing epoxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Polymerisation Methods In General (AREA)
- Graft Or Block Polymers (AREA)
- Surgical Instruments (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Dental Preparations (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/933,316 | 2001-08-20 | ||
| US09/933,316 US7687053B2 (en) | 2001-08-20 | 2001-08-20 | Embolic compositions with non-cyanoacrylate rheology modifying agents |
| PCT/US2002/021532 WO2003016364A1 (en) | 2001-08-20 | 2002-07-09 | Embolic compositions with non-cyanoacrylate rheology modifying agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2452505A1 true CA2452505A1 (en) | 2003-02-27 |
Family
ID=25463727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002452505A Abandoned CA2452505A1 (en) | 2001-08-20 | 2002-07-09 | Embolic compositions with non-cyanoacrylate rheology modifying agents |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7687053B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1425319B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP4238131B2 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE374219T1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2452505A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE60222680T2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2003016364A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070032853A1 (en) * | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
| RU2286801C2 (ru) * | 2001-05-01 | 2006-11-10 | Институт Нефтехимического Синтеза Имени А.В. Топчиева Российской Академии Наук | Двухфазные биоадгезионные композиции, абсорбирующие воду |
| US7687053B2 (en) * | 2001-08-20 | 2010-03-30 | Boston Scientific Scimed, Inc. | Embolic compositions with non-cyanoacrylate rheology modifying agents |
| US7131997B2 (en) | 2002-03-29 | 2006-11-07 | Scimed Life Systems, Inc. | Tissue treatment |
| US7462366B2 (en) | 2002-03-29 | 2008-12-09 | Boston Scientific Scimed, Inc. | Drug delivery particle |
| US7094369B2 (en) | 2002-03-29 | 2006-08-22 | Scimed Life Systems, Inc. | Processes for manufacturing polymeric microspheres |
| US7053134B2 (en) | 2002-04-04 | 2006-05-30 | Scimed Life Systems, Inc. | Forming a chemically cross-linked particle of a desired shape and diameter |
| US7459142B2 (en) * | 2002-06-06 | 2008-12-02 | Micro Therapeutics, Inc. | High viscosity embolizing compositions comprising prepolymers |
| US8425549B2 (en) | 2002-07-23 | 2013-04-23 | Reverse Medical Corporation | Systems and methods for removing obstructive matter from body lumens and treating vascular defects |
| US7449236B2 (en) | 2002-08-09 | 2008-11-11 | Boston Scientific Scimed, Inc. | Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient |
| US7588825B2 (en) | 2002-10-23 | 2009-09-15 | Boston Scientific Scimed, Inc. | Embolic compositions |
| ATE403469T1 (de) * | 2003-02-26 | 2008-08-15 | Micro Therapeutics Inc | Emboliezusammensetzungen enthaltend pyrogenes silicium |
| US20050025707A1 (en) * | 2003-02-27 | 2005-02-03 | Patterson William R. | Fumed silica embolic compositions |
| US20050158272A1 (en) * | 2004-01-07 | 2005-07-21 | Trivascular, Inc. | Methods, compositions and devices for embolizing body lumens |
| US8173176B2 (en) | 2004-03-30 | 2012-05-08 | Boston Scientific Scimed, Inc. | Embolization |
| CN101426454B (zh) | 2004-05-25 | 2012-06-06 | 泰科保健集团有限合伙公司 | 柔软的血管栓塞装置 |
| US9675476B2 (en) | 2004-05-25 | 2017-06-13 | Covidien Lp | Vascular stenting for aneurysms |
| CA2758946C (en) | 2004-05-25 | 2014-10-21 | Tyco Healthcare Group Lp | Vascular stenting for aneurysms |
| US7311861B2 (en) | 2004-06-01 | 2007-12-25 | Boston Scientific Scimed, Inc. | Embolization |
| US7963287B2 (en) | 2005-04-28 | 2011-06-21 | Boston Scientific Scimed, Inc. | Tissue-treatment methods |
| US9463426B2 (en) | 2005-06-24 | 2016-10-11 | Boston Scientific Scimed, Inc. | Methods and systems for coating particles |
| US20070078207A1 (en) * | 2005-09-30 | 2007-04-05 | Jonn Jerry Y | Stabilizer cyanoacrylate formulations |
| US7501179B2 (en) | 2005-12-21 | 2009-03-10 | Boston Scientific Scimed, Inc. | Block copolymer particles |
| US20070184087A1 (en) * | 2006-02-06 | 2007-08-09 | Bioform Medical, Inc. | Polysaccharide compositions for use in tissue augmentation |
| WO2007100556A1 (en) | 2006-02-22 | 2007-09-07 | Ev3 Inc. | Embolic protection systems having radiopaque filter mesh |
| US9393135B2 (en) * | 2006-05-12 | 2016-07-19 | CARDINAL HEALTH SWITZERLAND 515 GmbH | Balloon expandable bioabsorbable drug eluting stent |
| CA2652871C (en) * | 2006-05-12 | 2016-01-12 | Cordis Corporation | Balloon expandable bioabsorbable drug eluting flexible stent |
| CN101917927A (zh) * | 2007-11-12 | 2010-12-15 | 维勒医学有限公司 | 医用级氰基丙烯酸酯的单瓶制剂 |
| US7972373B2 (en) * | 2007-12-19 | 2011-07-05 | Advanced Technologies And Regenerative Medicine, Llc | Balloon expandable bioabsorbable stent with a single stress concentration region interconnecting adjacent struts |
| AU2009239424B9 (en) | 2008-04-21 | 2014-10-09 | Covidien Lp | Braid-ball embolic devices and delivery systems |
| WO2009140437A1 (en) | 2008-05-13 | 2009-11-19 | Nfocus Neuromedical, Inc. | Braid implant delivery systems |
| BRPI1008909B8 (pt) | 2009-02-20 | 2021-06-22 | Covidien Lp | sistema para tratar uma veia |
| US8409269B2 (en) | 2009-12-21 | 2013-04-02 | Covidien Lp | Procedures for vascular occlusion |
| WO2012034135A1 (en) | 2010-09-10 | 2012-03-15 | Maria Aboytes | Devices and methods for the treatment of vascular defects |
| US8998947B2 (en) | 2010-09-10 | 2015-04-07 | Medina Medical, Inc. | Devices and methods for the treatment of vascular defects |
| WO2012078678A1 (en) | 2010-12-06 | 2012-06-14 | Tyco Healthcare Group Lp | Vascular remodeling device |
| WO2012134990A1 (en) | 2011-03-25 | 2012-10-04 | Tyco Healthcare Group Lp | Vascular remodeling device |
| US10196543B2 (en) | 2011-03-31 | 2019-02-05 | Adhezion Biomedical, Llc | Fast bonding hair/eyelash extension adhesive compositions based on medical grade high viscosity cyanoacrylates |
| CN103547222B (zh) | 2011-05-11 | 2016-02-10 | 柯惠有限合伙公司 | 脉管重塑装置 |
| WO2013013080A1 (en) | 2011-07-20 | 2013-01-24 | Sapheon, Inc. | Enhanced ultrasound visualization of intravascular devices |
| US9060886B2 (en) | 2011-09-29 | 2015-06-23 | Covidien Lp | Vascular remodeling device |
| US9072620B2 (en) | 2011-11-04 | 2015-07-07 | Covidien Lp | Protuberant aneurysm bridging device deployment method |
| US9011480B2 (en) | 2012-01-20 | 2015-04-21 | Covidien Lp | Aneurysm treatment coils |
| US8808620B1 (en) | 2012-02-22 | 2014-08-19 | Sapheon, Inc. | Sterilization process design for a medical adhesive |
| US9452070B2 (en) | 2012-10-31 | 2016-09-27 | Covidien Lp | Methods and systems for increasing a density of a region of a vascular device |
| US10327781B2 (en) | 2012-11-13 | 2019-06-25 | Covidien Lp | Occlusive devices |
| CN110169802B (zh) | 2013-03-15 | 2022-07-08 | 柯惠有限合伙公司 | 血管植入物的输送与分离机构 |
| CN105142545B (zh) | 2013-03-15 | 2018-04-06 | 柯惠有限合伙公司 | 闭塞装置 |
| WO2015073704A1 (en) | 2013-11-13 | 2015-05-21 | Covidien Lp | Galvanically assisted attachment of medical devices to thrombus |
| EP3091904A1 (en) * | 2014-01-07 | 2016-11-16 | Covidien LP | Cyanoacrylate compositions including non-agglomerating radiopaque nanoparticles |
| EP3129077A4 (en) * | 2014-04-11 | 2017-11-22 | Covidien LP | Tagged surgical instruments and methods therefor |
| US9713475B2 (en) | 2014-04-18 | 2017-07-25 | Covidien Lp | Embolic medical devices |
| US9814466B2 (en) | 2014-08-08 | 2017-11-14 | Covidien Lp | Electrolytic and mechanical detachment for implant delivery systems |
| US10314593B2 (en) | 2015-09-23 | 2019-06-11 | Covidien Lp | Occlusive devices |
| US10478194B2 (en) | 2015-09-23 | 2019-11-19 | Covidien Lp | Occlusive devices |
| EP3432826B1 (en) | 2016-03-24 | 2024-10-02 | Covidien LP | Thin wall constructions for vascular flow diversion |
| US10828037B2 (en) | 2016-06-27 | 2020-11-10 | Covidien Lp | Electrolytic detachment with fluid electrical connection |
| US10828039B2 (en) | 2016-06-27 | 2020-11-10 | Covidien Lp | Electrolytic detachment for implantable devices |
| US11051822B2 (en) | 2016-06-28 | 2021-07-06 | Covidien Lp | Implant detachment with thermal activation |
| US10478195B2 (en) | 2016-08-04 | 2019-11-19 | Covidien Lp | Devices, systems, and methods for the treatment of vascular defects |
| US10576099B2 (en) | 2016-10-21 | 2020-03-03 | Covidien Lp | Injectable scaffold for treatment of intracranial aneurysms and related technology |
| US10675036B2 (en) | 2017-08-22 | 2020-06-09 | Covidien Lp | Devices, systems, and methods for the treatment of vascular defects |
| US11065009B2 (en) | 2018-02-08 | 2021-07-20 | Covidien Lp | Vascular expandable devices |
| US11065136B2 (en) | 2018-02-08 | 2021-07-20 | Covidien Lp | Vascular expandable devices |
| US10905432B2 (en) | 2018-08-22 | 2021-02-02 | Covidien Lp | Aneurysm treatment coils and associated systems and methods of use |
| US10912569B2 (en) | 2018-08-22 | 2021-02-09 | Covidien Lp | Aneurysm treatment coils and associated systems and methods of use |
| US11278291B2 (en) | 2018-12-17 | 2022-03-22 | Covidien Lp | Devices, systems, and methods for the treatment of vascular defects |
| US11826863B2 (en) | 2019-11-04 | 2023-11-28 | Covidien Lp | Systems and methods for treating aneurysms |
| US11931041B2 (en) | 2020-05-12 | 2024-03-19 | Covidien Lp | Devices, systems, and methods for the treatment of vascular defects |
| CN112870428B (zh) * | 2021-01-21 | 2022-05-27 | 北京冠合医疗科技有限公司 | 一种显影清晰的栓塞材料及其制备方法 |
| EP4308013A1 (en) | 2021-03-16 | 2024-01-24 | Covidien LP | Injectable biopolymer compositions and associated systems and methods |
| CN115364272B (zh) * | 2022-09-09 | 2023-08-08 | 江西博恩锐尔生物科技有限公司 | 柔软度可调的血管栓塞剂及其制备方法 |
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| NL125172C (cg-RX-API-DMAC7.html) | 1961-04-20 | |||
| US3896077A (en) * | 1966-10-10 | 1975-07-22 | Fred Leonard | Underwater adhesive |
| US3728375A (en) | 1971-05-12 | 1973-04-17 | Eastman Kodak Co | Cyanoacrylate adhesive compositions |
| US4406878A (en) * | 1978-08-02 | 1983-09-27 | Eastman Kodak Company | Iodinated contrast agent for radiography |
| DE2850918A1 (de) * | 1978-11-24 | 1980-06-04 | Bayer Ag | Roentgenopake dentalwerkstoffe auf basis von organischen kunststoffen in pastoeser form |
| IL63876A0 (en) | 1980-10-20 | 1981-12-31 | Population Res Inc | Radiopaque cyanoacrylates |
| US4713235A (en) * | 1981-05-26 | 1987-12-15 | Crx Medical, Inc. | Radiopaque cyanoacrylates |
| CA1225585A (en) * | 1983-06-30 | 1987-08-18 | Maria T. Litvinova | Composition for embolization of blood vessels |
| US5322499A (en) | 1985-09-20 | 1994-06-21 | Liprie Sam F | Continuous sheated low dose radioactive core adapted for cutting into short sealed segments |
| GB8729140D0 (en) | 1987-12-14 | 1988-01-27 | Lingner & Fischer Gmbh | Adhesive |
| US5326552A (en) * | 1992-12-17 | 1994-07-05 | Sterling Winthrop Inc. | Formulations for nanoparticulate x-ray blood pool contrast agents using high molecular weight nonionic surfactants |
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| US5739205A (en) * | 1994-06-08 | 1998-04-14 | Taoka Chemical Company, Limited | α-cyanoacrylate adhesive composition |
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| US5795922A (en) * | 1995-06-06 | 1998-08-18 | Clemson University | Bone cement composistion containing microencapsulated radiopacifier and method of making same |
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-
2001
- 2001-08-20 US US09/933,316 patent/US7687053B2/en not_active Expired - Lifetime
-
2002
- 2002-07-09 DE DE60222680T patent/DE60222680T2/de not_active Expired - Lifetime
- 2002-07-09 CA CA002452505A patent/CA2452505A1/en not_active Abandoned
- 2002-07-09 EP EP02746922A patent/EP1425319B1/en not_active Expired - Lifetime
- 2002-07-09 JP JP2003521688A patent/JP4238131B2/ja not_active Expired - Lifetime
- 2002-07-09 AT AT02746922T patent/ATE374219T1/de not_active IP Right Cessation
- 2002-07-09 WO PCT/US2002/021532 patent/WO2003016364A1/en not_active Ceased
-
2008
- 2008-11-11 JP JP2008288650A patent/JP2009072610A/ja active Pending
-
2010
- 2010-02-17 US US12/707,373 patent/US20100144895A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60222680D1 (de) | 2007-11-08 |
| WO2003016364A1 (en) | 2003-02-27 |
| US20030039696A1 (en) | 2003-02-27 |
| DE60222680T2 (de) | 2008-06-12 |
| JP2009072610A (ja) | 2009-04-09 |
| US20100144895A1 (en) | 2010-06-10 |
| ATE374219T1 (de) | 2007-10-15 |
| US7687053B2 (en) | 2010-03-30 |
| EP1425319B1 (en) | 2007-09-26 |
| EP1425319A1 (en) | 2004-06-09 |
| JP4238131B2 (ja) | 2009-03-11 |
| JP2005500414A (ja) | 2005-01-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |