CA2450583A1 - Antihistamines for the treatment of nasal congestion and nasal obstruction - Google Patents
Antihistamines for the treatment of nasal congestion and nasal obstruction Download PDFInfo
- Publication number
- CA2450583A1 CA2450583A1 CA002450583A CA2450583A CA2450583A1 CA 2450583 A1 CA2450583 A1 CA 2450583A1 CA 002450583 A CA002450583 A CA 002450583A CA 2450583 A CA2450583 A CA 2450583A CA 2450583 A1 CA2450583 A1 CA 2450583A1
- Authority
- CA
- Canada
- Prior art keywords
- day
- amount
- desloratadine
- treating
- allergic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000739 antihistaminic agent Substances 0.000 title claims abstract description 33
- 206010028735 Nasal congestion Diseases 0.000 title claims abstract description 27
- 206010028748 Nasal obstruction Diseases 0.000 title claims abstract description 19
- 229940125715 antihistaminic agent Drugs 0.000 title abstract description 12
- 238000011282 treatment Methods 0.000 title description 17
- JAUOIFJMECXRGI-UHFFFAOYSA-N Neoclaritin Chemical compound C=1C(Cl)=CC=C2C=1CCC1=CC=CN=C1C2=C1CCNCC1 JAUOIFJMECXRGI-UHFFFAOYSA-N 0.000 claims abstract description 55
- 229960001271 desloratadine Drugs 0.000 claims abstract description 55
- 230000000172 allergic effect Effects 0.000 claims abstract description 25
- 208000010668 atopic eczema Diseases 0.000 claims abstract description 24
- 230000004968 inflammatory condition Effects 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims description 53
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims description 21
- 230000001387 anti-histamine Effects 0.000 claims description 21
- JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 claims description 17
- 239000000850 decongestant Substances 0.000 claims description 16
- 229960003088 loratadine Drugs 0.000 claims description 16
- 230000000694 effects Effects 0.000 claims description 15
- 201000010105 allergic rhinitis Diseases 0.000 claims description 14
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 claims description 13
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims description 13
- 229960003592 fexofenadine Drugs 0.000 claims description 13
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 claims description 13
- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical group CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 claims description 13
- 229960003908 pseudoephedrine Drugs 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 13
- 208000036284 Rhinitis seasonal Diseases 0.000 claims description 11
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 claims description 10
- 229960001803 cetirizine Drugs 0.000 claims description 10
- 208000017022 seasonal allergic rhinitis Diseases 0.000 claims description 10
- SFOVDSLXFUGAIV-UHFFFAOYSA-N 1-[(4-fluorophenyl)methyl]-n-piperidin-4-ylbenzimidazol-2-amine Chemical compound C1=CC(F)=CC=C1CN1C2=CC=CC=C2N=C1NC1CCNCC1 SFOVDSLXFUGAIV-UHFFFAOYSA-N 0.000 claims description 9
- BAWMMJAUVBLLEE-UHFFFAOYSA-N 2-[2-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]ethoxy]acetic acid Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(F)=CC=1)C1=CC=C(F)C=C1 BAWMMJAUVBLLEE-UHFFFAOYSA-N 0.000 claims description 9
- GXDALQBWZGODGZ-UHFFFAOYSA-N astemizole Chemical compound C1=CC(OC)=CC=C1CCN1CCC(NC=2N(C3=CC=CC=C3N=2)CC=2C=CC(F)=CC=2)CC1 GXDALQBWZGODGZ-UHFFFAOYSA-N 0.000 claims description 9
- 229940124581 decongestants Drugs 0.000 claims description 8
- 229960001971 ebastine Drugs 0.000 claims description 8
- MJJALKDDGIKVBE-UHFFFAOYSA-N ebastine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(=O)CCCN1CCC(OC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 MJJALKDDGIKVBE-UHFFFAOYSA-N 0.000 claims description 8
- 229950003420 efletirizine Drugs 0.000 claims description 8
- 229960003449 epinastine Drugs 0.000 claims description 8
- WHWZLSFABNNENI-UHFFFAOYSA-N epinastine Chemical compound C1C2=CC=CC=C2C2CN=C(N)N2C2=CC=CC=C21 WHWZLSFABNNENI-UHFFFAOYSA-N 0.000 claims description 8
- 230000002411 adverse Effects 0.000 claims description 6
- 206010020751 Hypersensitivity Diseases 0.000 claims description 5
- 206010061218 Inflammation Diseases 0.000 claims description 4
- 208000006673 asthma Diseases 0.000 claims description 4
- 230000004054 inflammatory process Effects 0.000 claims description 4
- 206010039094 Rhinitis perennial Diseases 0.000 claims description 3
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 3
- 206010044565 Tremor Diseases 0.000 claims description 3
- 201000009961 allergic asthma Diseases 0.000 claims description 3
- 230000006793 arrhythmia Effects 0.000 claims description 3
- 206010003119 arrhythmia Diseases 0.000 claims description 3
- 208000002173 dizziness Diseases 0.000 claims description 3
- 206010022437 insomnia Diseases 0.000 claims description 3
- 208000022719 perennial allergic rhinitis Diseases 0.000 claims description 3
- 230000009467 reduction Effects 0.000 claims description 3
- 208000030961 allergic reaction Diseases 0.000 claims description 2
- 206010049153 Allergic sinusitis Diseases 0.000 claims 2
- 230000008030 elimination Effects 0.000 claims 2
- 238000003379 elimination reaction Methods 0.000 claims 2
- 208000024891 symptom Diseases 0.000 description 35
- 208000027744 congestion Diseases 0.000 description 11
- 239000008194 pharmaceutical composition Substances 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 9
- 208000036071 Rhinorrhea Diseases 0.000 description 8
- 206010039101 Rhinorrhoea Diseases 0.000 description 8
- 239000002552 dosage form Substances 0.000 description 8
- 239000000902 placebo Substances 0.000 description 8
- 229940068196 placebo Drugs 0.000 description 8
- 239000002253 acid Substances 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 206010039085 Rhinitis allergic Diseases 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 208000026935 allergic disease Diseases 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 239000003937 drug carrier Substances 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 230000001624 sedative effect Effects 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 206010015946 Eye irritation Diseases 0.000 description 2
- 206010052140 Eye pruritus Diseases 0.000 description 2
- RRJFVPUCXDGFJB-UHFFFAOYSA-N Fexofenadine hydrochloride Chemical compound Cl.C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RRJFVPUCXDGFJB-UHFFFAOYSA-N 0.000 description 2
- -1 HN03 Chemical class 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 206010052437 Nasal discomfort Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 239000013566 allergen Substances 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 229960004754 astemizole Drugs 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 210000005069 ears Anatomy 0.000 description 2
- 239000012458 free base Substances 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 210000001331 nose Anatomy 0.000 description 2
- 210000003254 palate Anatomy 0.000 description 2
- 230000001932 seasonal effect Effects 0.000 description 2
- 206010041232 sneezing Diseases 0.000 description 2
- ZKLPARSLTMPFCP-OAQYLSRUSA-N 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid Chemical compound C1CN(CCOCC(=O)O)CCN1[C@@H](C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-OAQYLSRUSA-N 0.000 description 1
- HQWVDUUIOCFXPO-UHFFFAOYSA-N 2-[2-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]ethoxy]acetic acid;dihydrochloride Chemical compound Cl.Cl.C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(F)=CC=1)C1=CC=C(F)C=C1 HQWVDUUIOCFXPO-UHFFFAOYSA-N 0.000 description 1
- RWTNPBWLLIMQHL-LJAQVGFWSA-N 2-[4-[(1s)-1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-ium-1-yl]butyl]phenyl]-2-methylpropanoate Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1[C@@H](O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-LJAQVGFWSA-N 0.000 description 1
- QFDDBBKJOGTVNI-PVTQAGNOSA-N 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid;(1s,2s)-2-(methylamino)-1-phenylpropan-1-ol;dihydrochloride Chemical compound Cl.Cl.CN[C@@H](C)[C@@H](O)C1=CC=CC=C1.C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 QFDDBBKJOGTVNI-PVTQAGNOSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- PVLJETXTTWAYEW-UHFFFAOYSA-N Mizolastine Chemical compound N=1C=CC(=O)NC=1N(C)C(CC1)CCN1C1=NC2=CC=CC=C2N1CC1=CC=C(F)C=C1 PVLJETXTTWAYEW-UHFFFAOYSA-N 0.000 description 1
- 206010039580 Scar Diseases 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 229940060533 allegra-d Drugs 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229960004342 cetirizine hydrochloride Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical class C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 1
- 229940088529 claritin Drugs 0.000 description 1
- 229940066051 combinations of antihistamines Drugs 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- DLNKOYKMWOXYQA-UHFFFAOYSA-N dl-pseudophenylpropanolamine Natural products CC(N)C(O)C1=CC=CC=C1 DLNKOYKMWOXYQA-UHFFFAOYSA-N 0.000 description 1
- 229960000354 fexofenadine hydrochloride Drugs 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000003434 inspiratory effect Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 201000010659 intrinsic asthma Diseases 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229960001508 levocetirizine Drugs 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 229960001144 mizolastine Drugs 0.000 description 1
- KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical compound C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 description 1
- 230000010352 nasal breathing Effects 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 208000037916 non-allergic rhinitis Diseases 0.000 description 1
- 239000003605 opacifier Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 description 1
- 229960001802 phenylephrine Drugs 0.000 description 1
- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 description 1
- 229960000395 phenylpropanolamine Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- ALDITMKAAPLVJK-UHFFFAOYSA-N prop-1-ene;hydrate Chemical group O.CC=C ALDITMKAAPLVJK-UHFFFAOYSA-N 0.000 description 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Substances CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 229940127558 rescue medication Drugs 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 208000014745 severe cutaneous adverse reaction Diseases 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 238000010181 skin prick test Methods 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29963601P | 2001-06-20 | 2001-06-20 | |
| US29963701P | 2001-06-20 | 2001-06-20 | |
| US60/299,636 | 2001-06-20 | ||
| US60/299,637 | 2001-06-20 | ||
| PCT/US2002/019414 WO2003000264A1 (en) | 2001-06-20 | 2002-06-19 | Antihistamines for the treatment of nasal congestion and nasal obstruction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2450583A1 true CA2450583A1 (en) | 2003-01-03 |
Family
ID=26971322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002450583A Abandoned CA2450583A1 (en) | 2001-06-20 | 2002-06-19 | Antihistamines for the treatment of nasal congestion and nasal obstruction |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1401444A1 (es) |
| JP (1) | JP2004534820A (es) |
| CN (1) | CN1518448A (es) |
| BR (1) | BR0210534A (es) |
| CA (1) | CA2450583A1 (es) |
| HU (1) | HUP0401630A2 (es) |
| MX (1) | MXPA03011705A (es) |
| NO (1) | NO20035706D0 (es) |
| WO (1) | WO2003000264A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1633359A1 (en) * | 2003-05-28 | 2006-03-15 | Ucb Farchim S.A. | Use of efletirizine for treating persistent allergic rhinitis |
| CN100444841C (zh) * | 2004-11-10 | 2008-12-24 | 鲁南制药集团股份有限公司 | 氯雷他定的外用制剂 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4829064A (en) * | 1987-06-08 | 1989-05-09 | Analgesic Associates | Cough/cold mixtures comprising non-sedating antihistamine drugs |
| US4990535A (en) * | 1989-05-03 | 1991-02-05 | Schering Corporation | Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine |
| DE4394931T1 (de) * | 1992-09-03 | 1995-07-20 | Sepracor Inc | Verwendung von Norastemizol zur Behandlung von allergischen Erkrankungen |
| US5314697A (en) * | 1992-10-23 | 1994-05-24 | Schering Corporation | Stable extended release oral dosage composition comprising loratadine and pseudoephedrine |
| BR9407414A (pt) * | 1993-09-07 | 1996-11-12 | Procter & Gamble | Composições contendo um sal de aminoácido de agente antiinflamatório não-esteroide de ácido propiônico e pelo menos um descongestionante um expectorante um anti-histamina e um antitussivo |
| EP0811374A1 (en) * | 1996-05-29 | 1997-12-10 | Pfizer Inc. | Combination dosage form comprising cetirizine and pseudoephedrine |
| WO1998018470A1 (en) * | 1996-10-31 | 1998-05-07 | Schering Corporation | Composition, for the treatment of asthma, containing loratadine and a decongestant |
| JP2001517626A (ja) * | 1997-09-19 | 2001-10-09 | ザ、プロクター、エンド、ギャンブル、カンパニー | 呼吸疾患を治療するための組成物及び方法 |
| WO1999032125A1 (en) * | 1997-12-23 | 1999-07-01 | Schering Corporation | Composition for treating respiratory and skin diseases, comprising at least one leukotriene antagonist and at least one antihistamine |
| US6248308B1 (en) * | 1998-04-14 | 2001-06-19 | Sepracor Inc. | Methods of using norastemizole in combination with leukotriene inhibitors to treat or prevent asthma |
| ATE311928T1 (de) * | 1998-07-01 | 2005-12-15 | Warner Lambert Co | (-)-pseudoephedrin als sympathomimetisches arzneimittel |
| WO2000050015A1 (en) * | 1999-02-23 | 2000-08-31 | Yuhan Corporation | Pharmaceutical capsule compositions containing loratadine and pseudoephedrine |
| US6114346A (en) * | 1999-10-22 | 2000-09-05 | Schering Corporation | Treating sleep disorders using desloratadine |
| WO2001045668A2 (en) * | 1999-12-20 | 2001-06-28 | Schering Corporation | Stable extended release oral dosage composition comprising pseudoephedrine and desloratadine |
| AU3800601A (en) * | 2000-02-03 | 2001-08-14 | Schering Corporation | Treating allergic and inflammatory conditions |
| PE20020324A1 (es) * | 2000-10-06 | 2002-06-18 | Boehringer Ingelheim Int | Nuevas composiciones farmaceuticas que contienen epinastina y pseudoefedrina |
-
2002
- 2002-06-19 CN CNA028122763A patent/CN1518448A/zh active Pending
- 2002-06-19 CA CA002450583A patent/CA2450583A1/en not_active Abandoned
- 2002-06-19 JP JP2003506909A patent/JP2004534820A/ja active Pending
- 2002-06-19 WO PCT/US2002/019414 patent/WO2003000264A1/en not_active Application Discontinuation
- 2002-06-19 HU HU0401630A patent/HUP0401630A2/hu unknown
- 2002-06-19 EP EP02742204A patent/EP1401444A1/en not_active Withdrawn
- 2002-06-19 BR BR0210534-9A patent/BR0210534A/pt not_active IP Right Cessation
- 2002-06-19 MX MXPA03011705A patent/MXPA03011705A/es not_active Application Discontinuation
-
2003
- 2003-12-19 NO NO20035706A patent/NO20035706D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0401630A2 (hu) | 2004-12-28 |
| JP2004534820A (ja) | 2004-11-18 |
| EP1401444A1 (en) | 2004-03-31 |
| BR0210534A (pt) | 2004-06-22 |
| CN1518448A (zh) | 2004-08-04 |
| MXPA03011705A (es) | 2004-03-19 |
| NO20035706D0 (no) | 2003-12-19 |
| WO2003000264A1 (en) | 2003-01-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20060276495A1 (en) | Treatment methods of nasal congestion and nasal obstruction | |
| Bernstein et al. | Efficacy and safety of fexofenadine hydrochloride for treatment of seasonal allergic rhinitis | |
| Day et al. | Onset of action, efficacy, and safety of a single dose of fexofenadine hydrochloride for ragweed allergy using an environmental exposure unit | |
| Bronsky et al. | Effectiveness and safety of fexofenadine, a new nonsedating H1-receptor antagonist, in the treatment of fall allergies | |
| Aaronson | Evaluation of cetirizine in patients with allergic rhinitis and perennial asthma | |
| US20080262018A1 (en) | Treating allergic and inflammatory conditions | |
| AU731756B2 (en) | Composition, for the treatment of asthma, containing loratadine and a decongestant | |
| JP5385402B2 (ja) | 肥満細胞媒介疾患を治療するための１−アミノ−アルキルシクロヘキサン誘導体 | |
| US6432972B2 (en) | Treating allergic and inflammatory conditions | |
| Day | Pros and cons of the use of antihistamines in managing allergic rhinitis | |
| Livostin Study Group | A comparison of topical levocabastine and oral terfenadine in the treatment of allergic rhinoconjunctivitis | |
| Frossard et al. | Onset of action in the nasal antihistaminic effect of cetirizine and loratadine in patients with allergic rhinitis | |
| CA2450583A1 (en) | Antihistamines for the treatment of nasal congestion and nasal obstruction | |
| Kaiser et al. | Comparative efficacy and safety of once-daily versus twice-daily loratadine-pseudoephedrine combinations versus placebo in seasonal allergic rhinitis | |
| Corren et al. | Onset and duration of action of levocabastine nasal spray in atopic patients under nasal challenge conditions | |
| AU2002315357A1 (en) | Antihistamines for the treatment of nasal congestion and nasal obstruction | |
| Stern et al. | Rapid and sustained efficacy of mizolastine 10 mg once daily in seasonal allergic rhinitis | |
| Heithoff et al. | 1121 Desloratadine improves quality of life in patients with seasonal allergic rhinitis | |
| EP1214071A2 (en) | Treating allergic and inflammatory conditions using desloratadine | |
| CA2383211A1 (en) | Use of desloratadine for treating allergic and inflammatory conditions | |
| Hébert et al. | Loratadine and pseudoephedrine sulfate: a double-blind, placebo-controlled comparison of a combination tablet (SCH 434) and its individual components in seasonal allergic rhinitis | |
| US20050203117A1 (en) | Treating allergic and inflammatory conditions | |
| AU2006201218A1 (en) | Treating allergic and inflammatory conditions | |
| EP1239859A2 (en) | Use of desloratadine for treating allergic and inflammatory conditions in pediatric patients | |
| Shareeah et al. | Double‐blind, parallel, randomized pilot study comparing the efficacy and tolerance of cetirizine 10 mg, mequitazine 2× 5 mg and placebo in the treatment of patients suffering from chronic urticaria: Comparison of suppressive effects on histamine‐induced weals and flares |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |