CA2450315A1 - Ligands des recepteurs de dopamine et procedes therapeutiques correspondants - Google Patents

Ligands des recepteurs de dopamine et procedes therapeutiques correspondants Download PDF

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Publication number
CA2450315A1
CA2450315A1 CA002450315A CA2450315A CA2450315A1 CA 2450315 A1 CA2450315 A1 CA 2450315A1 CA 002450315 A CA002450315 A CA 002450315A CA 2450315 A CA2450315 A CA 2450315A CA 2450315 A1 CA2450315 A1 CA 2450315A1
Authority
CA
Canada
Prior art keywords
receptor
compound
dopamine
subject
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002450315A
Other languages
English (en)
Inventor
Shaomeng Wang
Judith Varady
Xihan Wu
Min JI
Ke Ding
Beth Levant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2450315A1 publication Critical patent/CA2450315A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des composés désignés comme ligands (<i>e</i>.<i>g</i>., agonistes, antagonistes et agonistes partiels) pour les récepteurs de dopamine (<i>e</i>.<i>g</i>., D¿1?, D¿2?, D¿3?, D¿4? et D¿5?) et notamment les récepteurs de dopamine D¿1?, D¿2? et D¿3?. La présente invention concerne aussi des procédés de conception rationnelle de ces composants et des procédés thérapeutiques de leur utilisation.
CA002450315A 2001-06-13 2002-06-13 Ligands des recepteurs de dopamine et procedes therapeutiques correspondants Abandoned CA2450315A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
USUNKNOWN 1999-10-26
US29744501P 2001-06-13 2001-06-13
US60/297,445 2001-06-13
PCT/US2002/018914 WO2002100350A2 (fr) 2001-06-13 2002-06-13 Ligands des recepteurs de dopamine et procedes therapeutiques correspondants

Publications (1)

Publication Number Publication Date
CA2450315A1 true CA2450315A1 (fr) 2002-12-19

Family

ID=23146337

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002450315A Abandoned CA2450315A1 (fr) 2001-06-13 2002-06-13 Ligands des recepteurs de dopamine et procedes therapeutiques correspondants

Country Status (3)

Country Link
EP (1) EP1406631A4 (fr)
CA (1) CA2450315A1 (fr)
WO (1) WO2002100350A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104997743A (zh) * 2008-07-16 2015-10-28 吉瑞工厂 包含多巴胺受体配体的药物制剂

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10226459A1 (de) * 2002-06-13 2004-01-08 Neurobiotec Gmbh Verwendung von Dopamin-Partialagonisten zur Behandlung des Restless Legs Syndroms
EP1588704A1 (fr) * 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Dérivés d'alpha-aminoamides utiles dans le traitement de l'acroparesthésie nocturne et des troubles de toxicomanie
US7538112B2 (en) 2004-05-07 2009-05-26 Merck & Co., Inc. HIV integrase inhibitors
US8518933B2 (en) 2009-04-23 2013-08-27 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US8546377B2 (en) 2009-04-23 2013-10-01 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
ES2423668T3 (es) 2009-05-22 2013-09-23 Abbvie Inc. Moduladores de receptores 5-HT y métodos de uso de los mismos
AU2010353724B2 (en) 2010-05-21 2015-02-12 AbbVie Deutschland GmbH & Co. KG Modulators of 5-HT receptors and methods of use thereof
US9717779B2 (en) 2011-01-31 2017-08-01 Warsaw Orthopedic, Inc. Implantable matrix having optimum ligand concentrations
KR102426986B1 (ko) 2015-06-17 2022-07-28 화이자 인코포레이티드 삼환형 화합물 및 포스포다이에스터라제 억제제로서 이의 용도
US10751327B2 (en) 2015-08-19 2020-08-25 East Carolina University Treatment and management of augmentation in restless legs syndrome
CN105418605B (zh) * 2015-11-23 2017-12-22 东南大学 一种改进的含氮三环类多巴胺d3受体配体的制备方法
EP3380483A1 (fr) 2015-11-25 2018-10-03 Abbvie Deutschland GmbH & Co. KG Hexahydropyrazinobenz- ou -pyrido-oxazépines transportant un substituant contenant de l'oxygène et son utilisation pour le traitement d'affections conditionnées par 5-ht2c

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH493546A (de) * 1966-10-05 1970-07-15 Ciba Geigy Verfahren zur Herstellung neuer Pyrazino (1,2-a)-chinoline
US3647791A (en) * 1967-09-19 1972-03-07 Ciba Geigy Corp 2 3 4 4a 5 6-hexahydro - 1h - pyrazino (1 2-a) quinolines and pharmaceutical compositions containing same
WO1994020497A1 (fr) * 1993-03-01 1994-09-15 Merck Sharp & Dohme Limited Derives de pyrrolo-pyridine
ES2201105T3 (es) * 1994-08-05 2004-03-16 Pfizer Inc. Derivados del bencimidazol con actividad dopaminergica.
WO1996023789A1 (fr) * 1995-02-03 1996-08-08 Sankyo Company, Limited Derives d'hexahydropyrazinoquinoline
US5688950A (en) * 1996-04-23 1997-11-18 Neurogen Corporation Tricyclic aminoalkylcarboxamides; novel dopamine D3 receptor subtype specific ligands

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104997743A (zh) * 2008-07-16 2015-10-28 吉瑞工厂 包含多巴胺受体配体的药物制剂

Also Published As

Publication number Publication date
EP1406631A2 (fr) 2004-04-14
EP1406631A4 (fr) 2005-03-23
WO2002100350A2 (fr) 2002-12-19
WO2002100350A3 (fr) 2003-05-22

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FZDE Dead