CA2442739A1 - Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding the antigens, and methods of use - Google Patents

Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding the antigens, and methods of use Download PDF

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Publication number
CA2442739A1
CA2442739A1 CA002442739A CA2442739A CA2442739A1 CA 2442739 A1 CA2442739 A1 CA 2442739A1 CA 002442739 A CA002442739 A CA 002442739A CA 2442739 A CA2442739 A CA 2442739A CA 2442739 A1 CA2442739 A1 CA 2442739A1
Authority
CA
Canada
Prior art keywords
novx
nucleic acid
polypeptide
protein
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002442739A
Other languages
English (en)
French (fr)
Inventor
Muralidhara Padigaru
Suresh G. Shenoy
Ramesh Kekuda
Luca Rastelli
Peter S. Mezes
Glennda Smithson
Xiaojia Guo
Valerie Gerlach
Stacie J. Casman
Ferenc L. Boldog
Li Li
Bryan D. Zerhusen
Velizar T. Tchernev
Esha A. Gangolli
Corine A. M. Vernet
Kimberly A. Spytek
Uriel M. Malyankar
Meera Patturajan
Charles E. Miller
Raymond J. Taupier, Jr.
Melvyn P. Heyes
Jingfang Ju
John A. Peyman
Elina Catterton
John R. Macdougall
Shlomit R. Edinger
David J. Stone
Ann Mazur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CuraGen Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/114,153 external-priority patent/US20030185815A1/en
Application filed by Individual filed Critical Individual
Publication of CA2442739A1 publication Critical patent/CA2442739A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/0115—N-Acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (2.4.1.150)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA002442739A 2001-04-03 2002-04-03 Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding the antigens, and methods of use Abandoned CA2442739A1 (en)

Applications Claiming Priority (51)

Application Number Priority Date Filing Date Title
US28108601P 2001-04-03 2001-04-03
US60/281,086 2001-04-03
US28190601P 2001-04-05 2001-04-05
US60/281,906 2001-04-05
US28202001P 2001-04-06 2001-04-06
US60/282,020 2001-04-06
US28293001P 2001-04-10 2001-04-10
US60/282,930 2001-04-10
US28344401P 2001-04-12 2001-04-12
US28351201P 2001-04-12 2001-04-12
US60/283,444 2001-04-12
US60/283,512 2001-04-12
US28367801P 2001-04-13 2001-04-13
US28365701P 2001-04-13 2001-04-13
US28371001P 2001-04-13 2001-04-13
US60/283,657 2001-04-13
US60/283,678 2001-04-13
US60/283,710 2001-04-13
US28423401P 2001-04-17 2001-04-17
US60/284,234 2001-04-17
US28532501P 2001-04-19 2001-04-19
US60/285,325 2001-04-19
US28538101P 2001-04-20 2001-04-20
US60/285,381 2001-04-20
US28606801P 2001-04-24 2001-04-24
US60/286,068 2001-04-24
US28629201P 2001-04-25 2001-04-25
US60/286,292 2001-04-25
US29669201P 2001-06-07 2001-06-07
US60/296,692 2001-06-07
US30088301P 2001-06-26 2001-06-26
US60/300,883 2001-06-26
US31100301P 2001-08-08 2001-08-08
US60/311,003 2001-08-08
US31197301P 2001-08-13 2001-08-13
US60/311,973 2001-08-13
US31290101P 2001-08-16 2001-08-16
US60/312,901 2001-08-16
US32228301P 2001-09-14 2001-09-14
US60/322,283 2001-09-14
US32744801P 2001-10-05 2001-10-05
US60/327,448 2001-10-05
US34573401P 2001-12-31 2001-12-31
US60/345,734 2001-12-31
US34575502P 2002-01-03 2002-01-03
US60/345,755 2002-01-03
US35439102P 2002-02-04 2002-02-04
US60/354,391 2002-02-04
US10/114,153 2002-04-02
US10/114,153 US20030185815A1 (en) 2001-04-03 2002-04-02 Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding the antigens, and methods of use
PCT/US2002/010366 WO2002081625A2 (en) 2001-04-03 2002-04-03 Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding the antigens, and methods of use

Publications (1)

Publication Number Publication Date
CA2442739A1 true CA2442739A1 (en) 2002-10-17

Family

ID=28795516

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002442739A Abandoned CA2442739A1 (en) 2001-04-03 2002-04-03 Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding the antigens, and methods of use

Country Status (3)

Country Link
EP (1) EP1390057A4 (enExample)
JP (1) JP2005507236A (enExample)
CA (1) CA2442739A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2484842T3 (es) * 2006-11-10 2014-08-12 Livtech Inc. Anticuerpo anti-DLK-1 humana que muestra la actividad antitumoral in vivo
ES2527521T3 (es) 2008-03-17 2015-01-26 Livtech Inc. Anticuerpos antihumanos frente a Dlk-1 que tienen actividad antitumoral
EP3172228B1 (en) * 2014-07-25 2019-02-27 Theravectys Lentiviral vectors for regulated expression of a chimeric antigen receptor molecule

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004507202A (ja) * 1999-03-31 2004-03-11 キュラジェン　コーポレイション ポリペプチドをコードするオープンリーディングフレームを含む核酸；「ｏｒｆｘ」
US20030096312A1 (en) * 2000-05-02 2003-05-22 Claudia Wilm Novel natrium-calcium exchanger protein

Also Published As

Publication number Publication date
JP2005507236A (ja) 2005-03-17
EP1390057A2 (en) 2004-02-25
EP1390057A4 (en) 2005-10-12

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Legal Events

Date Code Title Description
FZDE Discontinued