CA2442015A1 - Facteur letal de l'anthrax inhibant la croissance tumorale et l'angiogenese - Google Patents

Facteur letal de l'anthrax inhibant la croissance tumorale et l'angiogenese Download PDF

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Publication number
CA2442015A1
CA2442015A1 CA002442015A CA2442015A CA2442015A1 CA 2442015 A1 CA2442015 A1 CA 2442015A1 CA 002442015 A CA002442015 A CA 002442015A CA 2442015 A CA2442015 A CA 2442015A CA 2442015 A1 CA2442015 A1 CA 2442015A1
Authority
CA
Canada
Prior art keywords
tumor
angiogenesis
inhibitor
mek
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002442015A
Other languages
English (en)
Inventor
Nicholas S. Duesbery
Craig P. Webb
George F. Vandewoude
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Van Andel Research Institute
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2442015A1 publication Critical patent/CA2442015A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une méthode permettant d'inhiber l'angiogénèse cellulaire, consistant à mettre en contact des cellules associées à une angiogénèse non souhaitée avec une quantité efficace d'un inhibiteur de MEK ou d'une enzyme qui appartient à la famille MAPK. Les inhibiteurs MEK comprennent des protéases spécifiques de MEK, telles que le facteur létal Bacillus anthracis ou un dérivé fonctionnel de ce dernier. Des petits inhibiteurs moléculaires organiques de MEK comprennent PD98059, U0126 et PD184352. Cette mise en contact peut être réalisée in vivo, chez un patient humain ou chez un autre sujet mammifère. L'invention concerne également une méthode permettant de traiter un sujet mammifère présentant un trouble ou une affection associé à une angiogénèse non souhaitée ou à une néovascularisation, laquelle méthode consiste à administrer au sujet une quantité efficace d'une composition pharmaceutique comprenant un inhibiteur de MEK ou une enzyme appartenant à la famille MAPK susmentionnée, et un véhicule ou excipient pharmaceutiquement acceptable. La méthode thérapeutique peut être utile pour une maladie ou une affection, telle que la croissance tumorale, l'invasion tumorale ou la métastase tumorale, dans laquelle l'inhibition de l'angiogénèse se traduit par la réduction de la taille ou de la vitesse de croissance de la tumeur, ou encore, par sa destruction.
CA002442015A 2001-03-22 2002-03-22 Facteur letal de l'anthrax inhibant la croissance tumorale et l'angiogenese Abandoned CA2442015A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27762501P 2001-03-22 2001-03-22
US60/277,625 2001-03-22
PCT/US2002/008656 WO2002076496A1 (fr) 2001-03-22 2002-03-22 Facteur letal de l'anthrax inhibant la croissance tumorale et l'angiogenese

Publications (1)

Publication Number Publication Date
CA2442015A1 true CA2442015A1 (fr) 2002-10-03

Family

ID=23061685

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002442015A Abandoned CA2442015A1 (fr) 2001-03-22 2002-03-22 Facteur letal de l'anthrax inhibant la croissance tumorale et l'angiogenese

Country Status (4)

Country Link
EP (1) EP1377312A4 (fr)
AU (1) AU2002255852B2 (fr)
CA (1) CA2442015A1 (fr)
WO (1) WO2002076496A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8856201A (en) 2000-09-01 2002-03-13 Andel Inst Van Inhibition of mitogen-activated protein kinase (mapk) pathway: a selective therapeutic strategy against melanoma
NZ518726A (en) 2001-05-09 2004-06-25 Warner Lambert Co Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor
WO2004100978A1 (fr) * 2003-05-13 2004-11-25 Medvet Science Pty. Ltd. Procede de modulation de la transmigration cellulaire et agents utilises a cet effet
ATE451115T1 (de) * 2003-07-07 2009-12-15 Van Andel Res Inst Hemmung der tumor-angiogenese durch eine kombination von thrombospondin-1 und hemmern des vaskulären endothel-wachstumsfaktors
AU2004283148A1 (en) 2003-10-21 2005-05-06 Warner-Lambert Company Llc Polymorphic form of N-[(R)-2,3-Dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide
UA89035C2 (ru) 2003-12-03 2009-12-25 Лео Фарма А/С Эфиры гидроксамовых кислот и их фармацевтическое применение
AT504159A1 (de) * 2006-08-16 2008-03-15 Marlyn Nutraceuticals Inc Verwendung von proteasen
WO2009132397A1 (fr) * 2008-05-01 2009-11-05 University Of South Australia Procédés et agents pour la modulation du taux et/ou de l'activité de la protéine hif-2 alpha
US9592236B2 (en) 2011-04-28 2017-03-14 Duke University Methods of treating hemoglobinopathies
WO2013082511A1 (fr) * 2011-12-02 2013-06-06 Genentech, Inc. Procédés pour surmonter la résistance tumorale aux antagonistes de vegf
WO2014081760A1 (fr) 2012-11-20 2014-05-30 Duke University Procédés de traitement d'hémoglobinopathies

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5405941A (en) * 1993-04-15 1995-04-11 National Jewish Center For Immunology And Respiratory Medicine MEKK protein, capable of phosphorylating MEK
US5525625A (en) * 1995-01-24 1996-06-11 Warner-Lambert Company 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders
GB2323845A (en) * 1997-03-31 1998-10-07 Merck & Co Inc MEK inhibiting lactones
WO1999001426A1 (fr) * 1997-07-01 1999-01-14 Warner-Lambert Company Derives d'acide benzhydroxamique phenylamino 4-bromo ou 4-iodo et utilisation de ces derniers en tant qu'inhibiteurs de mek
EP1066401A2 (fr) * 1998-04-01 2001-01-10 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services Le facteur letal de l'anthrax est une protease de type kinase
US6147107A (en) * 1998-12-20 2000-11-14 Virginia Commonwealth University Specific inhibition of the P42/44 mitogen activated protein (map) kinase cascade sensitizes tumor cells
ID30250A (id) * 1998-12-22 2001-11-15 Warner Lambert Co Kemoterapi kombinasi
ATE311363T1 (de) * 1999-01-13 2005-12-15 Warner Lambert Co Sulfohydroxamsäure and sulfohydroxamate und ihre verwendung als mek-inhibitoren
SK9822001A3 (en) * 1999-01-13 2002-08-06 Warner Lambert Co 1-heterocycle substituted diarylamines, pharmaceutical compositions based thereon and their use in therapy
WO2000056706A1 (fr) * 1999-03-19 2000-09-28 Du Pont Pharmaceuticals Company Amino-thio-acrylonitriles utilises comme inhibiteurs des kinases mek
WO2000056725A1 (fr) * 1999-03-19 2000-09-28 Du Pont Pharmaceuticals Company N-adamant-1-yl-n'-[4-chlorobenzothiazol-2-yl] uree utilisee dans le traitement des inflammations et comme agent de radiosensibilisation anticancereux
GB9910580D0 (en) * 1999-05-08 1999-07-07 Zeneca Ltd Chemical compounds
GB9910577D0 (en) * 1999-05-08 1999-07-07 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
EP1377312A1 (fr) 2004-01-07
AU2002255852B2 (en) 2006-11-09
WO2002076496A1 (fr) 2002-10-03
EP1377312A4 (fr) 2004-10-06

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued