CA2442015A1 - Facteur letal de l'anthrax inhibant la croissance tumorale et l'angiogenese - Google Patents
Facteur letal de l'anthrax inhibant la croissance tumorale et l'angiogenese Download PDFInfo
- Publication number
- CA2442015A1 CA2442015A1 CA002442015A CA2442015A CA2442015A1 CA 2442015 A1 CA2442015 A1 CA 2442015A1 CA 002442015 A CA002442015 A CA 002442015A CA 2442015 A CA2442015 A CA 2442015A CA 2442015 A1 CA2442015 A1 CA 2442015A1
- Authority
- CA
- Canada
- Prior art keywords
- tumor
- angiogenesis
- inhibitor
- mek
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne une méthode permettant d'inhiber l'angiogénèse cellulaire, consistant à mettre en contact des cellules associées à une angiogénèse non souhaitée avec une quantité efficace d'un inhibiteur de MEK ou d'une enzyme qui appartient à la famille MAPK. Les inhibiteurs MEK comprennent des protéases spécifiques de MEK, telles que le facteur létal Bacillus anthracis ou un dérivé fonctionnel de ce dernier. Des petits inhibiteurs moléculaires organiques de MEK comprennent PD98059, U0126 et PD184352. Cette mise en contact peut être réalisée in vivo, chez un patient humain ou chez un autre sujet mammifère. L'invention concerne également une méthode permettant de traiter un sujet mammifère présentant un trouble ou une affection associé à une angiogénèse non souhaitée ou à une néovascularisation, laquelle méthode consiste à administrer au sujet une quantité efficace d'une composition pharmaceutique comprenant un inhibiteur de MEK ou une enzyme appartenant à la famille MAPK susmentionnée, et un véhicule ou excipient pharmaceutiquement acceptable. La méthode thérapeutique peut être utile pour une maladie ou une affection, telle que la croissance tumorale, l'invasion tumorale ou la métastase tumorale, dans laquelle l'inhibition de l'angiogénèse se traduit par la réduction de la taille ou de la vitesse de croissance de la tumeur, ou encore, par sa destruction.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27762501P | 2001-03-22 | 2001-03-22 | |
US60/277,625 | 2001-03-22 | ||
PCT/US2002/008656 WO2002076496A1 (fr) | 2001-03-22 | 2002-03-22 | Facteur letal de l'anthrax inhibant la croissance tumorale et l'angiogenese |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2442015A1 true CA2442015A1 (fr) | 2002-10-03 |
Family
ID=23061685
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002442015A Abandoned CA2442015A1 (fr) | 2001-03-22 | 2002-03-22 | Facteur letal de l'anthrax inhibant la croissance tumorale et l'angiogenese |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1377312A4 (fr) |
AU (1) | AU2002255852B2 (fr) |
CA (1) | CA2442015A1 (fr) |
WO (1) | WO2002076496A1 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1365796A2 (fr) * | 2000-09-01 | 2003-12-03 | Van Andel Institute | Inhibition de la voie de la proteine mapkkk: une strategie therapeutique selective contre les melanomes |
NZ518726A (en) | 2001-05-09 | 2004-06-25 | Warner Lambert Co | Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor |
US20070116687A1 (en) * | 2003-05-13 | 2007-05-24 | Medvet Science Pty, Ltd. | Method of modulating cellular transmigration and agents for use therein |
EP1648493B1 (fr) * | 2003-07-07 | 2009-12-09 | Van Andel Research Institute | Inhibition de l'angiogenese tumorale par combinaison de la thrombospondine-1 et des inhibiteurs du facteur de croissance endotheliale vasculaire |
RU2352558C2 (ru) | 2003-10-21 | 2009-04-20 | Уорнер-Ламберт Компани Ллс | Полиморфная форма n-[(r)-2,3-дигидроксипропокси]-3,4-дифтор-2-(2-фтор-4 йодфениламино)бензамида |
UA89035C2 (ru) | 2003-12-03 | 2009-12-25 | Лео Фарма А/С | Эфиры гидроксамовых кислот и их фармацевтическое применение |
AT504159A1 (de) | 2006-08-16 | 2008-03-15 | Marlyn Nutraceuticals Inc | Verwendung von proteasen |
WO2009132397A1 (fr) * | 2008-05-01 | 2009-11-05 | University Of South Australia | Procédés et agents pour la modulation du taux et/ou de l'activité de la protéine hif-2 alpha |
EP2701694A4 (fr) * | 2011-04-28 | 2014-10-08 | Univ Duke | Procédés de traitement d'hémoglobinopathies |
WO2013082511A1 (fr) * | 2011-12-02 | 2013-06-06 | Genentech, Inc. | Procédés pour surmonter la résistance tumorale aux antagonistes de vegf |
US9861685B2 (en) | 2012-11-20 | 2018-01-09 | Duke University | Methods of treating hemoglobinopathies |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5405941A (en) * | 1993-04-15 | 1995-04-11 | National Jewish Center For Immunology And Respiratory Medicine | MEKK protein, capable of phosphorylating MEK |
US5525625A (en) * | 1995-01-24 | 1996-06-11 | Warner-Lambert Company | 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders |
GB2323845A (en) * | 1997-03-31 | 1998-10-07 | Merck & Co Inc | MEK inhibiting lactones |
WO1999001426A1 (fr) * | 1997-07-01 | 1999-01-14 | Warner-Lambert Company | Derives d'acide benzhydroxamique phenylamino 4-bromo ou 4-iodo et utilisation de ces derniers en tant qu'inhibiteurs de mek |
CA2324379C (fr) * | 1998-04-01 | 2012-12-11 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Le facteur letal de l'anthrax est une protease de type kinase |
US6147107A (en) * | 1998-12-20 | 2000-11-14 | Virginia Commonwealth University | Specific inhibition of the P42/44 mitogen activated protein (map) kinase cascade sensitizes tumor cells |
EE200100339A (et) * | 1998-12-22 | 2002-10-15 | Warner-Lambert Company | Kombineeritud kemoteraapia |
ES2251851T3 (es) * | 1999-01-13 | 2006-05-01 | Warner-Lambert Company Llc | Acidos sulfohidroxamicos y sulfohidroxamatos y su uso com inhibidores mek. |
US6545030B1 (en) * | 1999-01-13 | 2003-04-08 | Warner-Lambert Company | 1-heterocycle substituted diarylamines |
AU3631500A (en) * | 1999-03-19 | 2000-10-09 | Du Pont Pharmaceuticals Company | N-adamant-1-yl-n'-(4-chlorobenzothiazol-2-yl) urea useful in the treatment of inflammation and as an anticancer radiosensitizing agent |
AU3761400A (en) * | 1999-03-19 | 2000-10-09 | Du Pont Pharmaceuticals Company | Amino-thio-acrylonitriles as mek inhibitors |
GB9910577D0 (en) * | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
GB9910580D0 (en) * | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
-
2002
- 2002-03-22 CA CA002442015A patent/CA2442015A1/fr not_active Abandoned
- 2002-03-22 EP EP02725277A patent/EP1377312A4/fr not_active Withdrawn
- 2002-03-22 AU AU2002255852A patent/AU2002255852B2/en not_active Ceased
- 2002-03-22 WO PCT/US2002/008656 patent/WO2002076496A1/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2002255852B2 (en) | 2006-11-09 |
WO2002076496A1 (fr) | 2002-10-03 |
EP1377312A1 (fr) | 2004-01-07 |
EP1377312A4 (fr) | 2004-10-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |