CA2440092A1 - Protein c variants - Google Patents

Protein c variants Download PDF

Info

Publication number
CA2440092A1
CA2440092A1 CA002440092A CA2440092A CA2440092A1 CA 2440092 A1 CA2440092 A1 CA 2440092A1 CA 002440092 A CA002440092 A CA 002440092A CA 2440092 A CA2440092 A CA 2440092A CA 2440092 A1 CA2440092 A1 CA 2440092A1
Authority
CA
Canada
Prior art keywords
variant
component
protein
apc
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002440092A
Other languages
English (en)
French (fr)
Inventor
Bjorn Dahlback
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TAC Thrombosis and Coagulation AB
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2440092A1 publication Critical patent/CA2440092A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA002440092A 2001-03-02 2002-03-01 Protein c variants Abandoned CA2440092A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27246601P 2001-03-02 2001-03-02
US60/272,466 2001-03-02
PCT/SE2002/000363 WO2002070681A1 (en) 2001-03-02 2002-03-01 Protein c variants

Publications (1)

Publication Number Publication Date
CA2440092A1 true CA2440092A1 (en) 2002-09-12

Family

ID=23039905

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002440092A Abandoned CA2440092A1 (en) 2001-03-02 2002-03-01 Protein c variants

Country Status (6)

Country Link
US (1) US20050059132A1 (enExample)
EP (1) EP1370649A1 (enExample)
JP (1) JP2004527239A (enExample)
AU (1) AU2002235073B2 (enExample)
CA (1) CA2440092A1 (enExample)
WO (1) WO2002070681A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6693075B1 (en) 1997-10-23 2004-02-17 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7247708B2 (en) 1997-10-23 2007-07-24 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
PT947585E (pt) * 1998-03-19 2001-11-30 Instrumentation Lab Spa Metodo in vitro melhorado, kits e reagentes para a peaquisa de defeitos de coagulacao sanguinea
EP1255821B1 (en) 2000-02-02 2004-12-29 Eli Lilly And Company Protein c derivatives
AU2001232799A1 (en) 2000-02-11 2001-08-20 Eli Lilly And Company Protein c derivatives
US20030211094A1 (en) 2001-06-26 2003-11-13 Nelsestuen Gary L. High molecular weight derivatives of vitamin k-dependent polypeptides
EP2242875A4 (en) * 2008-01-15 2012-04-04 Univ British Columbia PROTEIN-C-RS2069915 AS RESPONSE PREDICTOR FOR SURVIVAL RATE AND ADMINISTRATION OF AN ACTIVATED PROTEIN-C OR PROTEIN-C-SIMILAR COMPOUND
WO2012068519A2 (en) 2010-11-19 2012-05-24 Sirius Genomics Inc. Markers associated with response to activated protein c administration, and uses thereof
WO2023119230A1 (en) 2021-12-22 2023-06-29 L'oreal Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US538534A (en) * 1895-04-30 Book-holder
US431036A (en) * 1890-07-01 Spechtcatiobr
US807857A (en) * 1905-07-06 1905-12-19 Emil T Palmenberg Display-fixture.
US1779057A (en) * 1929-11-05 1930-10-21 Tolmach Samuel Toothbrush
US2439009A (en) * 1943-10-29 1948-04-06 Thurner Engineering Company Flexible joint
US2638299A (en) * 1948-05-07 1953-05-12 House Of Photography Inc Display mount
US2859983A (en) * 1954-04-30 1958-11-11 Rembrandt Lamp Corp Swivel type lamp socket support
US2861501A (en) * 1954-07-09 1958-11-25 George P Strelakos Portable light reflector with magnifying glass
US2910260A (en) * 1956-01-03 1959-10-27 David S Tanner Swivel stand for model airplanes
US2849712A (en) * 1956-12-31 1958-08-26 Hi Lo Tv Antenna Corp Antenna structure
US2950836A (en) * 1957-12-17 1960-08-30 Robert B Murdock Collapsible attachment
US3198408A (en) * 1964-06-19 1965-08-03 Lloyd E Benner Support for a manikin form
US3776649A (en) * 1972-08-23 1973-12-04 Barnes Eng Co Locking ball joint
US3789836A (en) * 1972-12-07 1974-02-05 Scott J Apparatus for the stimulation of blood circulation in feet and legs
US3947139A (en) * 1974-04-22 1976-03-30 Designs For Vision, Inc. Light sources employing universally adjustable ball and socket joints
US4066231A (en) * 1975-08-25 1978-01-03 Bahner Randal E Locking stand for small, portable devices
US4121893A (en) * 1976-04-28 1978-10-24 Gilles Morissette Ball and socket coupling
JPH0246296A (ja) * 1988-08-09 1990-02-15 Hoechst Japan Ltd 雑種プロテインｃ及びその製造方法
US5466078A (en) * 1989-07-07 1995-11-14 Health Care Keyboard Company Input keyboard apparatus for information processing and other keyboard devices
US4988065A (en) * 1989-07-10 1991-01-29 Signatures, Inc. Mounting device for ornamental object
US5088852A (en) * 1989-10-13 1992-02-18 Davister Michael D Pinned type connector means for lattice space structures
US5280871A (en) * 1992-09-30 1994-01-25 Chuang Ching Pao Securing base
US5513784A (en) * 1993-07-12 1996-05-07 Pretorius; Andries L. Carrier device for carrying and holding appliances
US5769369A (en) * 1995-04-28 1998-06-23 Meinel; James Mobile office stand for supporting a portable computer or electronic organizer in vehicles
US5792081A (en) * 1995-10-18 1998-08-11 Cross; Terry M. Limb massager
US6693075B1 (en) * 1997-10-23 2004-02-17 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6017882A (en) * 1997-10-23 2000-01-25 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6328270B1 (en) * 1999-11-12 2001-12-11 Elbex Video Ltd. Swivel joint with cable passage for a television camera or a case
US6758622B2 (en) * 2001-02-16 2004-07-06 Burton Technologies Llc Ball socket with improved pull-out force resistance
US20020190167A1 (en) * 2001-06-13 2002-12-19 Rodriguez Albert R. Apparatus for supporting a model aerospace craft

Also Published As

Publication number Publication date
WO2002070681A1 (en) 2002-09-12
EP1370649A1 (en) 2003-12-17
US20050059132A1 (en) 2005-03-17
AU2002235073B2 (en) 2007-02-01
JP2004527239A (ja) 2004-09-09

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead