CA2439322A1 - Nucleosides therapeutiques - Google Patents
Nucleosides therapeutiques Download PDFInfo
- Publication number
- CA2439322A1 CA2439322A1 CA002439322A CA2439322A CA2439322A1 CA 2439322 A1 CA2439322 A1 CA 2439322A1 CA 002439322 A CA002439322 A CA 002439322A CA 2439322 A CA2439322 A CA 2439322A CA 2439322 A1 CA2439322 A1 CA 2439322A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- formula
- active ingredient
- hepatitis
- cis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000002777 nucleoside Substances 0.000 title description 2
- 125000003835 nucleoside group Chemical group 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 238000011282 treatment Methods 0.000 claims abstract description 15
- 208000002672 hepatitis B Diseases 0.000 claims abstract description 9
- 150000001875 compounds Chemical class 0.000 claims description 47
- 238000000034 method Methods 0.000 claims description 18
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- 229960004413 flucytosine Drugs 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000011321 prophylaxis Methods 0.000 claims description 4
- XQSPYNMVSIKCOC-UHFFFAOYSA-N 4-amino-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one Chemical compound C1=C(F)C(N)=NC(=O)N1C1OC(CO)SC1 XQSPYNMVSIKCOC-UHFFFAOYSA-N 0.000 claims 1
- WJJSZTJGFCFNKI-UHFFFAOYSA-N 1,3-oxathiolane Chemical compound C1CSCO1 WJJSZTJGFCFNKI-UHFFFAOYSA-N 0.000 abstract description 3
- 229940127073 nucleoside analogue Drugs 0.000 abstract description 2
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- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 2
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- 206010016654 Fibrosis Diseases 0.000 description 2
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
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- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
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- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- 150000003833 nucleoside derivatives Chemical class 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
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- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
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- 238000005563 spheronization Methods 0.000 description 1
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- 125000001273 sulfonato group Chemical class [O-]S(*)(=O)=O 0.000 description 1
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- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
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- 229940116362 tragacanth Drugs 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- SMBZJSVIKJMSFP-UHFFFAOYSA-N trifluoromethyl hypofluorite Chemical compound FOC(F)(F)F SMBZJSVIKJMSFP-UHFFFAOYSA-N 0.000 description 1
- FTVLMFQEYACZNP-UHFFFAOYSA-N trimethylsilyl trifluoromethanesulfonate Chemical compound C[Si](C)(C)OS(=O)(=O)C(F)(F)F FTVLMFQEYACZNP-UHFFFAOYSA-N 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
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- 239000011701 zinc Substances 0.000 description 1
- 229940102001 zinc bromide Drugs 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919104741A GB9104741D0 (en) | 1991-03-06 | 1991-03-06 | Therapeutic nucleosides |
GB9104741.5 | 1991-03-06 | ||
CA002105486A CA2105486C (fr) | 1991-03-06 | 1992-03-05 | Nucleosides therapeutiques |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002105486A Division CA2105486C (fr) | 1991-03-06 | 1992-03-05 | Nucleosides therapeutiques |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2439322A1 true CA2439322A1 (fr) | 1992-09-17 |
Family
ID=10691102
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002439322A Abandoned CA2439322A1 (fr) | 1991-03-06 | 1992-03-05 | Nucleosides therapeutiques |
Country Status (5)
Country | Link |
---|---|
CA (1) | CA2439322A1 (fr) |
GB (1) | GB9104741D0 (fr) |
MY (1) | MY113560A (fr) |
SA (1) | SA92120445B1 (fr) |
ZA (1) | ZA921658B (fr) |
-
1991
- 1991-03-06 GB GB919104741A patent/GB9104741D0/en active Pending
-
1992
- 1992-03-05 MY MYPI92000358A patent/MY113560A/en unknown
- 1992-03-05 CA CA002439322A patent/CA2439322A1/fr not_active Abandoned
- 1992-03-05 ZA ZA921658A patent/ZA921658B/xx unknown
- 1992-04-14 SA SA92120445A patent/SA92120445B1/ar unknown
Also Published As
Publication number | Publication date |
---|---|
SA92120445B1 (ar) | 2005-10-05 |
GB9104741D0 (en) | 1991-04-17 |
MY113560A (en) | 2002-04-30 |
ZA921658B (en) | 1993-09-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry | ||
FZDE | Discontinued |
Effective date: 20130813 |