CA2439315A1 - Utilisation de peptides non complexants pour la preparation d'une composition destinee a la transfection d'un polynucleotide dans une cellule et compositions utiles en therapie genique - Google Patents

Utilisation de peptides non complexants pour la preparation d'une composition destinee a la transfection d'un polynucleotide dans une cellule et compositions utiles en therapie genique Download PDF

Info

Publication number
CA2439315A1
CA2439315A1 CA002439315A CA2439315A CA2439315A1 CA 2439315 A1 CA2439315 A1 CA 2439315A1 CA 002439315 A CA002439315 A CA 002439315A CA 2439315 A CA2439315 A CA 2439315A CA 2439315 A1 CA2439315 A1 CA 2439315A1
Authority
CA
Canada
Prior art keywords
leu
ala
peptide
lys
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002439315A
Other languages
English (en)
Inventor
Karola Rittner
Eric Jacobs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transgene SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2439315A1 publication Critical patent/CA2439315A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne l'utilisation de peptides non complexants pour préparer des compositions permettant d'améliorer le transfert de substances d'intérêt dans des cellules. De telles compositions sont particulièrement utiles en thérapie génique, en vaccination et en toute situation thérapeutique ou prophylactique dans laquelle une substance d'intérêt, notamment un acide nucléique, est administrée à des cellules in vivo.
CA002439315A 2001-02-27 2002-02-15 Utilisation de peptides non complexants pour la preparation d'une composition destinee a la transfection d'un polynucleotide dans une cellule et compositions utiles en therapie genique Abandoned CA2439315A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP01440049.3 2001-02-27
EP01440049 2001-02-27
US27798201P 2001-03-23 2001-03-23
US60/277,982 2001-03-23
EP01440133 2001-05-15
EP01440133.5 2001-05-15
US29318701P 2001-05-25 2001-05-25
US60/293,187 2001-05-25
PCT/EP2002/001646 WO2002074794A2 (fr) 2001-02-27 2002-02-15 Utilisation de peptides non complexants pour la preparation d'une composition destinee a la transfection d'un polynucleotide dans une cellule et compositions utiles en therapie genique

Publications (1)

Publication Number Publication Date
CA2439315A1 true CA2439315A1 (fr) 2002-09-26

Family

ID=27440161

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002439315A Abandoned CA2439315A1 (fr) 2001-02-27 2002-02-15 Utilisation de peptides non complexants pour la preparation d'une composition destinee a la transfection d'un polynucleotide dans une cellule et compositions utiles en therapie genique

Country Status (4)

Country Link
EP (1) EP1363675A2 (fr)
JP (1) JP2004534004A (fr)
CA (1) CA2439315A1 (fr)
WO (1) WO2002074794A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE490266T1 (de) * 2005-12-06 2010-12-15 Centre Nat Rech Scient In zellen eindringende peptide als träger für moleküle
US8242081B2 (en) 2005-12-06 2012-08-14 Centre National De La Recherche Scientifique Cell penetrating peptides for intracellular delivery of molecules
AU2010271238A1 (en) * 2009-07-10 2012-02-09 Trustees Of Tufts College Bioengineered silk protein-based nucleic acid delivery systems

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0832269A1 (fr) * 1995-06-07 1998-04-01 Baylor College Of Medicine Transporteurs d'acide nucleique servant a introduire des acides nucleiques dans une cellule
EP1161957A1 (fr) * 2000-05-26 2001-12-12 Transgene S.A. Complexe pour le transfert d'une substance anionique d' intérêt dans une cellule

Also Published As

Publication number Publication date
JP2004534004A (ja) 2004-11-11
EP1363675A2 (fr) 2003-11-26
WO2002074794A2 (fr) 2002-09-26
WO2002074794A3 (fr) 2003-02-27

Similar Documents

Publication Publication Date Title
US7906484B2 (en) Complex for transferring an anionic substance into a cell
US20020055174A1 (en) Complex for transferring an anionic substance of interest into a cell
AU781356B2 (en) Viral core protein-cationic lipid-nucleic acid-delivery complexes
JP3525393B2 (ja) 脂質及び例えばリポソーム中でのその使用
Zhang et al. Hybrids of nonviral vectors for gene delivery
US20070098702A1 (en) Recombinant protein polymer vectors for systemic gene delivery
Gjetting et al. Effective Nanoparticle‐based Gene Delivery by a Protease Triggered Charge Switch
EP1161957A1 (fr) Complexe pour le transfert d'une substance anionique d' intérêt dans une cellule
WO2002088370A2 (fr) Acides nucleiques autogenes codants pour une polymerase d'arn secretable
CA2439315A1 (fr) Utilisation de peptides non complexants pour la preparation d'une composition destinee a la transfection d'un polynucleotide dans une cellule et compositions utiles en therapie genique
US20040132188A1 (en) Use of non-complexing peptides for the preparation of a composition for transfection of a polynucleotide into a cell and compositions useful in gene therapy
AU2002247723A1 (en) Compositions useful in gene therapy
US20050261214A1 (en) Complexes for transferring substances of interest into a cell
AU770607B2 (en) Complex for transferring an anionic substance of interest into a cell
EP0987029B1 (fr) Utilisation des polymères cationiques pour la préparation de complexes d' acides nucléiques et compositions apparentées
Hwang et al. Recombinant mussel adhesive protein as a gene delivery material
EP1052288A1 (fr) Complexe pour le transfert d'une substance anionique dans une cellule
WO2000037664A1 (fr) Procede de preparation d'une suspension de posiplexes stables
EP1006197A1 (fr) L'utilisation d'un complexe immunologique pour la préparation d'une composition thérapeutique, utile pour la transfection des polynucléotides dans des cellules macropinocyte
Montier et al. 481. Efficient gene transfer into human epithelial cell lines using glycosylated cationic carriers and neutral glycosylated co-lipids
Christoph Uherek et al. Modular Fusion Proteins for Receptor-mediated Gene Delivery
Cationic 479. KLN-47, a Safe Lipophosphoramide Reagent, Efficiently Transfects (> 100 kb) Large Plasmids into Epithelial Cells
AU2002342319A1 (en) Complexes for transferring substances if interest into a cell

Legal Events

Date Code Title Description
FZDE Discontinued