CA2437412A1 - Delayed release microtablet of b-phenylpropiophenone derivatives - Google Patents
Delayed release microtablet of b-phenylpropiophenone derivatives Download PDFInfo
- Publication number
- CA2437412A1 CA2437412A1 CA002437412A CA2437412A CA2437412A1 CA 2437412 A1 CA2437412 A1 CA 2437412A1 CA 002437412 A CA002437412 A CA 002437412A CA 2437412 A CA2437412 A CA 2437412A CA 2437412 A1 CA2437412 A1 CA 2437412A1
- Authority
- CA
- Canada
- Prior art keywords
- active ingredient
- tablets
- derivatives
- tablet
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003111 delayed effect Effects 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 4
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- QGGZBXOADPVUPN-UHFFFAOYSA-N dihydrochalcone Chemical class C=1C=CC=CC=1C(=O)CCC1=CC=CC=C1 QGGZBXOADPVUPN-UHFFFAOYSA-N 0.000 abstract 1
- 239000007903 gelatin capsule Substances 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 230000000979 retarding effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention concerns cylindrical retarded-action tablets having convex or planar upper and lower surfaces and made of .beta.-phenylpropiophenone derivatives of formula (I) acting as the active ingredient, in which R = n-propyl or 1,1-dimethylpropyl, and pharmacologically acceptable salts of such derivatives, a) tablet height and diameter, independently of each other, being 1 to 3 mm; b) the concentration of the active ingredient lying in the range from 81 to 99.9 % by wt.
relative to the weight of the microtablet, neglecting the weight of any coating present;
c) the density of the active ingredient being greater than 1; d) at least 80 %
of the active ingredient being released between 3 hours and 24 hours when tested using the USP paddle model at 50 rpm; e) the rate of release being virtually independent of the pressure used to compress the tablet; f) the tablet containing no retarding-action auxiliaries but 0.1 to 5 % by wt. of a lubricant and 0 to 18.9 % by wt. of other usual auxiliaries. The invention also concerns a gelatin capsule containing 3 to 200 such tablets with the same or different release rates, plus a method of producing the tablets.
(See Formula I)
relative to the weight of the microtablet, neglecting the weight of any coating present;
c) the density of the active ingredient being greater than 1; d) at least 80 %
of the active ingredient being released between 3 hours and 24 hours when tested using the USP paddle model at 50 rpm; e) the rate of release being virtually independent of the pressure used to compress the tablet; f) the tablet containing no retarding-action auxiliaries but 0.1 to 5 % by wt. of a lubricant and 0 to 18.9 % by wt. of other usual auxiliaries. The invention also concerns a gelatin capsule containing 3 to 200 such tablets with the same or different release rates, plus a method of producing the tablets.
(See Formula I)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4310963A DE4310963C2 (en) | 1993-04-03 | 1993-04-03 | Retarded microtablets of beta-phenylpropiophenone derivatives |
| DEP4310963.2 | 1993-04-03 | ||
| CA002158166A CA2158166C (en) | 1993-04-03 | 1994-03-24 | Delayed release microtablet of .beta.-phenylpropiophenone derivatives |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002158166A Division CA2158166C (en) | 1993-04-03 | 1994-03-24 | Delayed release microtablet of .beta.-phenylpropiophenone derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2437412A1 true CA2437412A1 (en) | 1994-10-13 |
| CA2437412C CA2437412C (en) | 2005-05-03 |
Family
ID=29216669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002437412A Expired - Lifetime CA2437412C (en) | 1993-04-03 | 1994-03-24 | Delayed release microtablet of b-phenylpropiophenone derivatives |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2437412C (en) |
-
1994
- 1994-03-24 CA CA002437412A patent/CA2437412C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2437412C (en) | 2005-05-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20140324 |