CA2435510A1 - Procedes de criblage pour des substances qui inhibent l'interaction d'un recepteur de prostanoide fp avec un compose a alpha-activite pgf2.alpha. et methodes de traitement du cancer - Google Patents
Procedes de criblage pour des substances qui inhibent l'interaction d'un recepteur de prostanoide fp avec un compose a alpha-activite pgf2.alpha. et methodes de traitement du cancer Download PDFInfo
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- CA2435510A1 CA2435510A1 CA002435510A CA2435510A CA2435510A1 CA 2435510 A1 CA2435510 A1 CA 2435510A1 CA 002435510 A CA002435510 A CA 002435510A CA 2435510 A CA2435510 A CA 2435510A CA 2435510 A1 CA2435510 A1 CA 2435510A1
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- pgf2
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- 230000000722 protumoral effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000012723 sample buffer Substances 0.000 description 1
- 238000007423 screening assay Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- CMZUMMUJMWNLFH-UHFFFAOYSA-N sodium metavanadate Chemical compound [Na+].[O-][V](=O)=O CMZUMMUJMWNLFH-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000037439 somatic mutation Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 239000000225 tumor suppressor protein Substances 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 230000034512 ubiquitination Effects 0.000 description 1
- 238000010798 ubiquitination Methods 0.000 description 1
- 229910000166 zirconium phosphate Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La présente invention concerne des procédés de criblage pour des substances qui inhibent l'interaction entre un récepteur de prostanoïde FP et un composé présentant une activité PGF¿2.alpha.?, des procédés d'inhibition de cette interaction, des procédés d'inhibition de la signalisation à médiation de .beta.-caténine, ainsi que des méthodes de traitement du cancer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26350301P | 2001-01-24 | 2001-01-24 | |
| US60/263,503 | 2001-01-24 | ||
| PCT/US2002/000522 WO2002058546A2 (fr) | 2001-01-24 | 2002-01-24 | Procedes de criblage pour des substances qui inhibent l'interaction d'un recepteur de prostanoide fp avec un compose a activite pgf2$g(a), et methodes de traitement du cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2435510A1 true CA2435510A1 (fr) | 2002-08-01 |
Family
ID=23002040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002435510A Abandoned CA2435510A1 (fr) | 2001-01-24 | 2002-01-24 | Procedes de criblage pour des substances qui inhibent l'interaction d'un recepteur de prostanoide fp avec un compose a alpha-activite pgf2.alpha. et methodes de traitement du cancer |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1429648A4 (fr) |
| JP (1) | JP2004531223A (fr) |
| AU (1) | AU2002248322B2 (fr) |
| CA (1) | CA2435510A1 (fr) |
| WO (1) | WO2002058546A2 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004212335A1 (en) | 2003-02-14 | 2004-08-26 | Merck Serono Sa | Piperazine-2-carboxamide derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2369470T3 (es) * | 1998-09-17 | 2011-12-01 | Hopital Sainte-Justine | Antagonistas de un receptor acoplado a la proteina g. |
-
2002
- 2002-01-24 AU AU2002248322A patent/AU2002248322B2/en not_active Ceased
- 2002-01-24 WO PCT/US2002/000522 patent/WO2002058546A2/fr not_active Application Discontinuation
- 2002-01-24 JP JP2002558884A patent/JP2004531223A/ja active Pending
- 2002-01-24 EP EP02717306A patent/EP1429648A4/fr not_active Withdrawn
- 2002-01-24 CA CA002435510A patent/CA2435510A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002058546A2 (fr) | 2002-08-01 |
| WO2002058546A3 (fr) | 2004-04-08 |
| AU2002248322B2 (en) | 2005-06-09 |
| EP1429648A2 (fr) | 2004-06-23 |
| EP1429648A4 (fr) | 2005-03-30 |
| JP2004531223A (ja) | 2004-10-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |