CA2429856A1 - Gene adaptateur - Google Patents

Gene adaptateur Download PDF

Info

Publication number
CA2429856A1
CA2429856A1 CA002429856A CA2429856A CA2429856A1 CA 2429856 A1 CA2429856 A1 CA 2429856A1 CA 002429856 A CA002429856 A CA 002429856A CA 2429856 A CA2429856 A CA 2429856A CA 2429856 A1 CA2429856 A1 CA 2429856A1
Authority
CA
Canada
Prior art keywords
mars
protein
seq
nucleic acid
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002429856A
Other languages
English (en)
Inventor
Jane C. Mcglade
Michael P. Loreto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hospital for Sick Children HSC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002324663A external-priority patent/CA2324663A1/fr
Application filed by Individual filed Critical Individual
Priority to CA002429856A priority Critical patent/CA2429856A1/fr
Publication of CA2429856A1 publication Critical patent/CA2429856A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne l'identification et le clonage d'un nouveau gène appelé MARS (modulateur de la signalisation du récepteur d'antigène) qui est un gène de suppression des tumeurs présumé; ainsi que la relation existant entre le gène MARS et des cancers chez l'homme et l'utilisation de ce gène dans le diagnostic et le pronostic du cancer chez l'homme. Cette invention concerne également la thérapie des cancers chez l'homme pour lesquels il existe une mutation dans le gène MARS ou bien pour lesquels ledit gène MARS est manquant, la thérapie des cancers comprenant la thérapie génique, la thérapie par remplacement de protéines et les mimétiques de protéines; ainsi que le criblage de médicaments pour la thérapie anticancéreuse.
CA002429856A 2000-11-27 2001-11-26 Gene adaptateur Abandoned CA2429856A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002429856A CA2429856A1 (fr) 2000-11-27 2001-11-26 Gene adaptateur

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CA2,324,663 2000-11-27
CA002324663A CA2324663A1 (fr) 2000-11-27 2000-11-27 Un nouveau gene adaptateur
CA002429856A CA2429856A1 (fr) 2000-11-27 2001-11-26 Gene adaptateur
PCT/CA2001/001662 WO2002042452A2 (fr) 2000-11-27 2001-11-26 Gene adaptateur

Publications (1)

Publication Number Publication Date
CA2429856A1 true CA2429856A1 (fr) 2002-05-30

Family

ID=25682192

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002429856A Abandoned CA2429856A1 (fr) 2000-11-27 2001-11-26 Gene adaptateur

Country Status (1)

Country Link
CA (1) CA2429856A1 (fr)

Similar Documents

Publication Publication Date Title
US6162897A (en) 17q-linked breast and ovarian cancer susceptibility gene
US5709999A (en) Linked breast and ovarian cancer susceptibility gene
US6211334B1 (en) Cell-cycle regulatory proteins, and uses related thereto
JP4005135B2 (ja) 神経アポトーシス抑制性蛋白質(naip)の使用
JP2003516744A (ja) Bcl−gポリペプチド、それをコードする核酸および使用方法
US6562589B1 (en) AIB1, a novel steroid receptor co-activator
US7507801B2 (en) Adapter gene
WO1999055728A2 (fr) Genes ese et proteines
WO1998055151A1 (fr) Compositions renfermant une proteine (bin1) interagissant avec myc et dependant des sequences, et leurs utilisations
US20050153287A1 (en) Nr3b nmda receptor subunit compositions and related methods
WO1999026980A1 (fr) Reactifs et procedes d'utilisation de proteines de la famille sap, nouveaux regulateurs de transduction de signaux
CA2429856A1 (fr) Gene adaptateur
US6465629B1 (en) BRG1 is a tumor suppressor that is mutated in prostate and other cancer types
JP2004501604A (ja) Trade分子およびそれに関連する使用
JP2004524802A (ja) Phドメイン相互作用タンパク質
US20030104443A1 (en) AFAP sequences, polypeptides, antibodies and methods
CA2309677A1 (fr) Nouveaux gene et proteine exprimes dans les tissus nerveux et pancreatiques
US6337192B1 (en) MMSC1-an MMAC1 interacting protein
US20040072295A1 (en) Human RGR oncogene and truncated transcripts thereof detected in T cell malignancies, antibodies to the encoded polypeptides and methods of use
US6291173B1 (en) MMSC2—an MMAC1 interacting protein
US7118886B1 (en) Ese genes and proteins
AU743207B2 (en) Cell-cycle regulatory proteins, and uses related thereto
WO2001051509A2 (fr) Proteine 140 associee a shc (sap-140)
WO1998013494A9 (fr) Proteine fixatrice du gene wt1 suppresseur de la tumeur de wilm
WO1998013494A2 (fr) Proteine fixatrice du gene wt1 suppresseur de la tumeur de wilm

Legal Events

Date Code Title Description
FZDE Discontinued