CA2429100A1 - Microparticules destinees a l'administration parenterale - Google Patents

Microparticules destinees a l'administration parenterale Download PDF

Info

Publication number
CA2429100A1
CA2429100A1 CA002429100A CA2429100A CA2429100A1 CA 2429100 A1 CA2429100 A1 CA 2429100A1 CA 002429100 A CA002429100 A CA 002429100A CA 2429100 A CA2429100 A CA 2429100A CA 2429100 A1 CA2429100 A1 CA 2429100A1
Authority
CA
Canada
Prior art keywords
starch
microparticles
process according
active substance
biologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002429100A
Other languages
English (en)
Inventor
Mats Reslow
Monica Jonsson
Timo Laakso
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pacira Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0004218A external-priority patent/SE518008C2/sv
Application filed by Individual filed Critical Individual
Publication of CA2429100A1 publication Critical patent/CA2429100A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)

Abstract

L'invention concerne un procédé permettant de produire des microparticules contenant une substance active au niveau biologique. Ce procédé consiste à préparer une solution aqueuse de ladite substance, à mélanger cette solution avec une solution aqueuse de PEG telle que la substance est concentrée et/ou solidifiée, à nettoyer éventuellement la substance, à mélanger la substance avec une solution d'amidon aqueuse, à mélanger la composition obtenue, après addition de la solution d'amidon, avec une solution polymère, de manière à former une émulsion de gouttelettes d'amidon dans la solution polymère, les gouttelettes d'amidon étant solidifiées dans des microparticules, à sécher les microparticules et appliquer éventuellement une coquille de régulation d'administration à ses microparticules. L'invention concerne également les nouvelles microparticules pouvant être obtenues à l'aide de ce procédé.
CA002429100A 2000-11-16 2001-10-05 Microparticules destinees a l'administration parenterale Abandoned CA2429100A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE0004218A SE518008C2 (sv) 2000-11-16 2000-11-16 Parenteralt administrerbara mikropartiklar och förfarande för framställning av desamma
SE0004218-4 2000-11-16
US26049601P 2001-01-08 2001-01-08
US60/260,496 2001-01-08
PCT/SE2001/002166 WO2002039985A1 (fr) 2000-11-16 2001-10-05 Microparticules destinees a l'administration parenterale

Publications (1)

Publication Number Publication Date
CA2429100A1 true CA2429100A1 (fr) 2002-05-23

Family

ID=26655308

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002429100A Abandoned CA2429100A1 (fr) 2000-11-16 2001-10-05 Microparticules destinees a l'administration parenterale

Country Status (5)

Country Link
EP (1) EP1333814A1 (fr)
JP (1) JP2004513914A (fr)
AU (1) AU2001292527A1 (fr)
CA (1) CA2429100A1 (fr)
WO (1) WO2002039985A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0201599D0 (sv) * 2002-03-21 2002-05-30 Skyepharma Ab Microparticles
AU2004216909A1 (en) * 2003-03-04 2004-09-16 The Technology Development Company Ltd. Delivery system for drug and cell therapy
US8075919B2 (en) * 2003-07-18 2011-12-13 Baxter International Inc. Methods for fabrication, uses and compositions of small spherical particles prepared by controlled phase separation
US8333995B2 (en) * 2004-05-12 2012-12-18 Baxter International, Inc. Protein microspheres having injectable properties at high concentrations
US20100008982A1 (en) * 2006-04-24 2010-01-14 Eyal Shimoni Non-covalent complexes of bioactive agents with starch for oral delivery
KR102207030B1 (ko) * 2012-09-28 2021-01-22 세키스이 메디칼 가부시키가이샤 비희석계 면역 크로마토그래피법 시약에 있어서 희석 시료를 측정하기 위한 첨가물
CN106535875B (zh) * 2014-05-27 2022-03-18 港大科桥有限公司 全水性乳液的渗透干燥

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4713249A (en) * 1981-11-12 1987-12-15 Schroeder Ulf Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use thereof
SE459005B (sv) * 1985-07-12 1989-05-29 Aake Rikard Lindahl Saett att framstaella sfaeriska polymerpartiklar

Also Published As

Publication number Publication date
WO2002039985A1 (fr) 2002-05-23
JP2004513914A (ja) 2004-05-13
EP1333814A1 (fr) 2003-08-13
AU2001292527A1 (en) 2002-05-27

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued