CA2427617A1 - Medicinal compositions for concomitant use as anticancer agent - Google Patents

Medicinal compositions for concomitant use as anticancer agent Download PDF

Info

Publication number
CA2427617A1
CA2427617A1 CA002427617A CA2427617A CA2427617A1 CA 2427617 A1 CA2427617 A1 CA 2427617A1 CA 002427617 A CA002427617 A CA 002427617A CA 2427617 A CA2427617 A CA 2427617A CA 2427617 A1 CA2427617 A1 CA 2427617A1
Authority
CA
Canada
Prior art keywords
ring
salt
substituent group
anticancer agent
medicinal composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002427617A
Other languages
French (fr)
Other versions
CA2427617C (en
Inventor
Yoichi Ozawa
Kentaro Yoshimatsu
Junko Kai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai Co., Ltd.
Yoichi Ozawa
Kentaro Yoshimatsu
Junko Kai
Eisai R&D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co., Ltd., Yoichi Ozawa, Kentaro Yoshimatsu, Junko Kai, Eisai R&D Management Co., Ltd. filed Critical Eisai Co., Ltd.
Publication of CA2427617A1 publication Critical patent/CA2427617A1/en
Application granted granted Critical
Publication of CA2427617C publication Critical patent/CA2427617C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention provides a medicinal composition having an excellent antitumor activity. That is, it provides a medicinal composition comprising a sulfonamide compound, a sulfonate compound or a salt of them, which is represented by the following formula:

(see formula above) (wherein ring A represents an aromatic ring which may have a substituent group; ring B represents a 6-membered unsaturated hydrocarbon ring which may have a substituent group etc.; ring C represents a 5-membered hetero-ring containing one or two nitrogen atoms, and the ring C may have a substituent group;
W represents a single bond or -CH=CH-; X represents -NH- etc. ;
and Y represents a carbon atom or a nitrogen atom; and Z
represents -NH- etc.), particularly N-(3-chloro-1H-indol-7-yl)-4-sulfamoylbenzenesulfonamide or a salt thereof, combined with at least one substance selected from (1) irinotecan hydrochloride trihydrate; (2) mitomycin C; (3) 5-fluorouracil;
(4) cisplatin; (5) gemcitabine hydrochloride; (6) doxorubicin;
(7) taxol; and (8) a salt of the above-mentioned (1) to (7).
CA002427617A 2000-10-31 2001-10-31 Medicinal compositions for concomitant use as anticancer agent Expired - Fee Related CA2427617C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000333952 2000-10-31
JP2000-333952 2000-10-31
PCT/JP2001/009563 WO2002036117A1 (en) 2000-10-31 2001-10-31 Medicinal compositions for concominant use as anticancer atent

Publications (2)

Publication Number Publication Date
CA2427617A1 true CA2427617A1 (en) 2003-04-29
CA2427617C CA2427617C (en) 2009-10-06

Family

ID=18809950

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002427617A Expired - Fee Related CA2427617C (en) 2000-10-31 2001-10-31 Medicinal compositions for concomitant use as anticancer agent

Country Status (12)

Country Link
US (3) US20040002505A1 (en)
EP (1) EP1331005B1 (en)
JP (1) JP4167898B2 (en)
KR (1) KR100829875B1 (en)
CN (1) CN1196484C (en)
AT (1) ATE322264T1 (en)
AU (2) AU1099302A (en)
CA (1) CA2427617C (en)
DE (1) DE60118590T2 (en)
NZ (1) NZ524975A (en)
TW (1) TWI283575B (en)
WO (1) WO2002036117A1 (en)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60134679D1 (en) 2000-10-20 2008-08-14 Eisai R&D Man Co Ltd Nitrogen-containing aromatic heterocycles
US7994159B2 (en) * 2003-03-10 2011-08-09 Eisai R&D Management Co., Ltd. c-Kit kinase inhibitor
DE602004010900D1 (en) * 2003-05-08 2008-02-07 Eisai R&D Man Co Ltd MEDICAL COMPOSITIONS CONTAIN N- (3-CHLORO-1H-INDOL-7-YL) -4-SULFAMOYL-BENZENESULFONAMIDE AND OTHER CYTOSTATICS
US20070037854A1 (en) * 2003-09-10 2007-02-15 Kenji Hayashi Process for preparing sulfonamide-containing indole compounds
WO2005026118A1 (en) * 2003-09-10 2005-03-24 Eisai Co., Ltd. Crystal of sulfonamide-containing indole compound and process for producing the same
JP4303726B2 (en) 2003-11-11 2009-07-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 Urea derivative and method for producing the same
CZ2006427A3 (en) * 2003-12-29 2006-11-15 Sepracor Inc. Pyrrole and pyrazole DAAO inhibitors
WO2005082397A1 (en) * 2004-02-26 2005-09-09 The Penn State Research Foundation Combinatorial therapies for the treatment of neoplasias using the opioid growth factor receptor
US8969379B2 (en) 2004-09-17 2015-03-03 Eisai R&D Management Co., Ltd. Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide
US20090047365A1 (en) * 2005-02-28 2009-02-19 Eisai R & D Management Co., Ltd. Novel Concomitant Use of Sulfonamide Compound with Anti-Cancer Agent
CN1313104C (en) * 2005-05-27 2007-05-02 中国科学院南海海洋研究所 Anticancer medicine composition with synergistic bupleurum root and polymyxin
MX2008000250A (en) 2005-07-06 2008-03-19 Sepracor Inc Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2, 3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive dis
JP5066446B2 (en) * 2005-08-01 2012-11-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 Methods for predicting the effects of angiogenesis inhibitors
EP1925676A4 (en) 2005-08-02 2010-11-10 Eisai R&D Man Co Ltd Method for assay on the effect of vascularization inhibitor
CA2620594C (en) * 2005-09-01 2012-08-21 Eisai R&D Management Co., Ltd. Pharmaceutical composition having improved disintegratability
CN101316590B (en) * 2005-11-07 2011-08-03 卫材R&D管理有限公司 Use of combination of anti-angiogenic substance and c-kit kinase inhibitor
EP1964837A4 (en) * 2005-11-22 2010-12-22 Eisai R&D Man Co Ltd Anti-tumor agent for multiple myeloma
ES2566479T3 (en) * 2006-01-06 2016-04-13 Sunovion Pharmaceuticals Inc. Monoamine reabsorption inhibitors based on tetralone
AU2007205114B2 (en) 2006-01-06 2012-11-08 Sunovion Pharmaceuticals Inc. Cycloalkylamines as monoamine reuptake inhibitors
CN101421228B (en) 2006-03-31 2014-05-21 塞普拉柯公司 Preparation of chiral amides and amines
ES2556173T3 (en) * 2006-05-18 2016-01-13 Eisai R&D Management Co., Ltd. Antitumor agent for thyroid cancer
EP2044939A1 (en) * 2006-06-29 2009-04-08 Eisai R&D Management Co., Ltd. Therapeutic agent for liver fibrosis
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US20080058395A1 (en) * 2006-06-30 2008-03-06 Sepracor Inc. Fused heterocyclic inhibitors of D-amino acid oxidase
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US8865737B2 (en) 2006-08-28 2014-10-21 Eisai R&D Management Co., Ltd. Antitumor agent for undifferentiated gastric cancer
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
MX2009007410A (en) * 2007-01-18 2009-09-09 Sepracor Inc Inhibitors of d-amino acid oxidase.
EP2119707B1 (en) 2007-01-29 2015-01-14 Eisai R&D Management Co., Ltd. Composition for treatment of undifferentiated-type of gastric cancer
US8669291B2 (en) 2007-05-31 2014-03-11 Sunovion Pharmaceuticals Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
CN101848895B (en) * 2007-11-09 2013-10-23 卫材R&D管理有限公司 Combination of anti-angiogenic substance and anti-tumor platinum complex
AU2009210098B2 (en) * 2008-01-29 2013-06-13 Eisai R & D Management Co., Ltd. Combined use of angiogenesis inhibitor and taxane
CN101584696A (en) * 2008-05-21 2009-11-25 上海艾力斯医药科技有限公司 Composition containing quinazoline derivatives, preparation method and use
WO2010017418A1 (en) * 2008-08-07 2010-02-11 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US20110034434A1 (en) * 2009-08-07 2011-02-10 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US9012458B2 (en) 2010-06-25 2015-04-21 Eisai R&D Management Co., Ltd. Antitumor agent using compounds having kinase inhibitory effect in combination
WO2012144463A1 (en) 2011-04-18 2012-10-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 Therapeutic agent for tumor
WO2012166899A2 (en) 2011-06-03 2012-12-06 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
AU2013202947B2 (en) 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
KR20150098605A (en) 2012-12-21 2015-08-28 에자이 알앤드디 매니지먼트 가부시키가이샤 Amorphous form of quinoline derivative, and method for producing same
KR102204279B1 (en) 2013-05-14 2021-01-15 에자이 알앤드디 매니지먼트 가부시키가이샤 Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
ES2680444T3 (en) * 2014-01-17 2018-09-07 Oncoral Pharma Aps Solid oral dosage form of irinotecan for cancer treatment
RS63559B1 (en) 2014-08-28 2022-10-31 Eisai R&D Man Co Ltd High-purity quinoline derivative and method for manufacturing same
WO2016094402A1 (en) * 2014-12-09 2016-06-16 Merrimack Pharmaceuticals, Inc. Treatment of breast cancer with liposomal irinotecan
PL3263106T3 (en) 2015-02-25 2024-04-02 Eisai R&D Management Co., Ltd. Method for suppressing bitterness of quinoline derivative
AU2015384801B2 (en) 2015-03-04 2022-01-06 Eisai R&D Management Co., Ltd. Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer
US11318131B2 (en) 2015-05-18 2022-05-03 Ipsen Biopharm Ltd. Nanoliposomal irinotecan for use in treating small cell lung cancer
BR112017027227B1 (en) 2015-06-16 2023-12-12 Eisai R&D Management Co., Ltd ANTI-CANCER AGENT
WO2017031445A1 (en) 2015-08-20 2017-02-23 Merrimack Pharmaceuticals, Inc. Combination therapy for cancer treatment
CN108495629A (en) 2015-08-21 2018-09-04 益普生生物制药有限公司 Use the method comprising liposome Irinotecan and the combination therapy to treat metastatic cancer of pancreas of oxaliplatin
JP2019533684A (en) 2016-11-02 2019-11-21 イプセン バイオファーム リミティド Treatment of gastric cancer with combination therapy including liposomal irinotecan, oxaliplatin, 5-fluorouracil (and leucovorin)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3545461B2 (en) * 1993-09-10 2004-07-21 エーザイ株式会社 Bicyclic heterocycle-containing sulfonamide derivatives
ATE255106T1 (en) * 1993-09-10 2003-12-15 Eisai Co Ltd BICYCLIC, HETEROCYCLIC SULFONAMIDES AND SULFONIC ACID ESTERS
JPH09208571A (en) * 1996-02-02 1997-08-12 Takeda Chem Ind Ltd Alkylidenecyclohexane derivative
JP2000143635A (en) * 1998-06-10 2000-05-26 Takeda Chem Ind Ltd Arterialization inhibitor
JP2000247949A (en) * 1999-02-26 2000-09-12 Eisai Co Ltd Indole compound containing sulfonamide
US6911306B1 (en) * 1999-10-18 2005-06-28 Emory University TMS1 compositions and methods of use
EP1296714B1 (en) * 2000-06-22 2009-08-26 University Of Iowa Research Foundation Combination of CpG and antibodies directed against CD19,CD20, CD22 or CD40 for the treatment or prevention of cancer.

Also Published As

Publication number Publication date
AU2002210993B2 (en) 2006-12-07
ATE322264T1 (en) 2006-04-15
NZ524975A (en) 2004-11-26
TWI283575B (en) 2007-07-11
AU1099302A (en) 2002-05-15
WO2002036117A1 (en) 2002-05-10
CN1196484C (en) 2005-04-13
CA2427617C (en) 2009-10-06
JP4167898B2 (en) 2008-10-22
CN1473041A (en) 2004-02-04
US20040002505A1 (en) 2004-01-01
US20040224972A1 (en) 2004-11-11
EP1331005B1 (en) 2006-04-05
EP1331005A4 (en) 2004-12-22
EP1331005A1 (en) 2003-07-30
DE60118590D1 (en) 2006-05-18
KR20030046475A (en) 2003-06-12
KR100829875B1 (en) 2008-05-16
JPWO2002036117A1 (en) 2004-03-11
US20030215523A1 (en) 2003-11-20
DE60118590T2 (en) 2007-01-18

Similar Documents

Publication Publication Date Title
CA2427617A1 (en) Medicinal compositions for concomitant use as anticancer agent
CA2415010A1 (en) Propane-1,3-dione derivatives useful as gnrh receptor antagonist
IL154350A (en) Phenylalanine derivatives and pharmaceutical compositions containing them
CA2560510A1 (en) N-(1-arylpyrazol-4yl) sulfonamides and their use as parasiticides
EA200300412A1 (en) PHARMACEUTICAL ACTIVE DERIVATIVES OF SULPHONAMIDE, CONTAINING AS LYPOPHIL, SO AND IONIZABLE FRAGMENTS, AS AN INHIBITORS JUN-PROTEINKINAZ
KR900002784A (en) Pharmaceutical binding agents for use in antitumor therapy
CA2506441A1 (en) 5-substituted-pyrazine or pyridine glucokinase activators
EP1008588A4 (en) 11,15-o-dialkylprostaglandin e derivatives, process for producing the same, and drugs containing the same as the active ingredient
CO5580767A2 (en) INDAZOL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS TO INHIBIT PROTEINKINES AND PROCEDURES FOR USE
MXPA02011974A (en) Substituted quinazoline derivatives and their use as inhibitors.
GB0206860D0 (en) Compounds
IL174665A0 (en) Heterocyclic compounds which act as p-glycoprotein inhibitors and pharmaceutical compositions containing the same
CA2159450A1 (en) 1-amidinophenyl-pyrrolidones piperidinones azetinones as platelet aggregation inhibitors
CA2337825A1 (en) Disubstituted bicyclic heterocycles, the preparation thereof and their use as pharmaceutical compositions
TW200612920A (en) Novel imidazolidine derivatives
WO2002048148A3 (en) Pyrazolopyridine derivatives
HK1099200A1 (en) Anti-inflammatory agents
NO984470L (en) Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase
WO2003049690A3 (en) Hiv integrase inhibitors
EP1568382A4 (en) REMEDY FOR GLAUCOMA COMPRISING Rho KINASE INHIBITOR AND beta-BLOCKER
WO2003053971A8 (en) Pyridoquinoxaline antivirals
WO2003049676A3 (en) Modified prostaglandin compounds and analogs thereof, compositions containing the same useful for the teatment of cancer
CA2140927A1 (en) Platelet aggregation inhibitors
WO2007058568A3 (en) Salts of 9-oxoacridine-10-acetic acid with 1-alkylamino-1-desoxy-polyols
CA2535210A1 (en) Novel farnesyl protein transferase inhibitors as antitumor agents

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed