CA2426684A1 - Inhibiteurs de la prenyl-proteine transferase - Google Patents

Inhibiteurs de la prenyl-proteine transferase Download PDF

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Publication number
CA2426684A1
CA2426684A1 CA002426684A CA2426684A CA2426684A1 CA 2426684 A1 CA2426684 A1 CA 2426684A1 CA 002426684 A CA002426684 A CA 002426684A CA 2426684 A CA2426684 A CA 2426684A CA 2426684 A1 CA2426684 A1 CA 2426684A1
Authority
CA
Canada
Prior art keywords
unsubstituted
substituted
alkyl
heterocycle
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002426684A
Other languages
English (en)
Inventor
Ian M. Bell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2426684A1 publication Critical patent/CA2426684A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés spirocycliques qui inhibent la prényl-protéine transférase et la prénylation de la protéine oncogène Ras. L'invention concerne également des compositions chimiothérapeutiques contenant ces composés, ainsi que des procédés pour inhiber la prényl-protéine transférase et la prénylation de la protéine oncogène Ras.
CA002426684A 2000-10-25 2001-10-19 Inhibiteurs de la prenyl-proteine transferase Abandoned CA2426684A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24323600P 2000-10-25 2000-10-25
US60/243,236 2000-10-25
PCT/US2001/050527 WO2002060868A2 (fr) 2000-10-25 2001-10-19 Inhibiteurs de la prenyl-proteine transferase

Publications (1)

Publication Number Publication Date
CA2426684A1 true CA2426684A1 (fr) 2002-08-08

Family

ID=22917880

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002426684A Abandoned CA2426684A1 (fr) 2000-10-25 2001-10-19 Inhibiteurs de la prenyl-proteine transferase

Country Status (3)

Country Link
EP (1) EP1332134A2 (fr)
CA (1) CA2426684A1 (fr)
WO (1) WO2002060868A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014216178B2 (en) 2013-02-15 2018-06-28 KALA BIO, Inc. Therapeutic compounds and uses thereof
KR102277833B1 (ko) 2013-02-20 2021-07-14 칼라 파마슈티컬스, 인크. 치료 화합물 및 그의 용도
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
AU2014342042B2 (en) 2013-11-01 2017-08-17 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CA3036065A1 (fr) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Formes cristallines de composes therapeutiques et leurs utilisations
EP3509422A4 (fr) 2016-09-08 2020-05-20 Kala Pharmaceuticals, Inc. Formes cristallines de composés thérapeutiques et leurs utilisations
EP3509423A4 (fr) 2016-09-08 2020-05-13 Kala Pharmaceuticals, Inc. Formes cristallines de composés thérapeutiques et leurs utilisations

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU760027B2 (en) * 1998-07-02 2003-05-08 Merck & Co., Inc. Inhibitors of prenyl-protein transferase

Also Published As

Publication number Publication date
EP1332134A2 (fr) 2003-08-06
WO2002060868A2 (fr) 2002-08-08
WO2002060868A3 (fr) 2003-01-03

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Legal Events

Date Code Title Description
FZDE Dead