CA2424033A1 - Dispositif robotique automatise pour la cristallisation a controle dynamique de proteines - Google Patents

Dispositif robotique automatise pour la cristallisation a controle dynamique de proteines Download PDF

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Publication number
CA2424033A1
CA2424033A1 CA002424033A CA2424033A CA2424033A1 CA 2424033 A1 CA2424033 A1 CA 2424033A1 CA 002424033 A CA002424033 A CA 002424033A CA 2424033 A CA2424033 A CA 2424033A CA 2424033 A1 CA2424033 A1 CA 2424033A1
Authority
CA
Canada
Prior art keywords
reagent
chamber
sample
solution
dynamic dialysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002424033A
Other languages
English (en)
Inventor
Leonard Arnowitz
Emmanuel Steinberg
Mark W. Sawicki
Thomas C. S. Keller, Iii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BSI Proteomics Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2424033A1 publication Critical patent/CA2424033A1/fr
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00—Investigating or analyzing materials by the use of thermal means
    • G01N25/14—Investigating or analyzing materials by the use of thermal means by using distillation, extraction, sublimation, condensation, freezing, or crystallisation
    • G01N25/147—Investigating or analyzing materials by the use of thermal means by using distillation, extraction, sublimation, condensation, freezing, or crystallisation by cristallisation
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C30B29/58—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

La présente invention concerne un appareil et des procédés permettant le contrôle indépendant des transformations dynamiques provoquées par des réactifs d'une pluralité d'échantillons comprenant des protéines en cours de cristallisation et des cellules en cours de culture. L'invention propose un dispositif robotique automatique qui améliore la cristallisation des protéines en production élevée, au moyen de réservoirs de réactifs (28) reliés à des enceintes de réactifs (40), avec des chambres d'échantillons (44) communiquant avec les réservoirs de réactifs (28) via une membrane semi-perméable.
CA002424033A 2000-09-28 2001-09-28 Dispositif robotique automatise pour la cristallisation a controle dynamique de proteines Abandoned CA2424033A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US23592300P 2000-09-28 2000-09-28
US23592800P 2000-09-28 2000-09-28
US23592700P 2000-09-28 2000-09-28
US23592200P 2000-09-28 2000-09-28
US60/235,928 2000-09-28
US60/235,927 2000-09-28
US60/235,923 2000-09-28
US60/235,922 2000-09-28
PCT/US2001/030454 WO2002026342A1 (fr) 2000-09-28 2001-09-28 Dispositif robotique automatise pour la cristallisation a controle dynamique de proteines

Publications (1)

Publication Number Publication Date
CA2424033A1 true CA2424033A1 (fr) 2002-04-04

Family

ID=27499824

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002424033A Abandoned CA2424033A1 (fr) 2000-09-28 2001-09-28 Dispositif robotique automatise pour la cristallisation a controle dynamique de proteines

Country Status (5)

Country Link
EP (1) EP1444023A1 (fr)
AU (1) AU2002211293A1 (fr)
CA (1) CA2424033A1 (fr)
GB (1) GB2384729A (fr)
WO (1) WO2002026342A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8403888B2 (en) 2010-04-15 2013-03-26 Teneo Innovations Inc. Device and electronic controller for syringe piston control

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818060B2 (en) 1999-08-02 2004-11-16 Emerald Biostructures, Inc. Robot for mixing crystallization trial matrices
US6860940B2 (en) 2002-02-11 2005-03-01 The Regents Of The University Of California Automated macromolecular crystallization screening
US7463982B2 (en) 2004-12-22 2008-12-09 Lawrence Livermore National Security, Llc Liquid class predictor for liquid handling of complex mixtures
GB2554334A (en) 2016-05-17 2018-04-04 Tap Biosystems Phc Ltd Automated bioprocess development
JP6797717B2 (ja) * 2017-03-02 2020-12-09 千代田化工建設株式会社 タンパク質の結晶化方法および結晶化装置

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62106000A (ja) * 1985-10-30 1987-05-16 Fujitsu Ltd 生体高分子結晶自動作製装置
FR2604917B1 (fr) * 1986-10-09 1989-01-27 Aerospatiale Procede, cellule et dispositif de cristallogenese, notamment par vaisseau spatial
US5013531A (en) * 1990-08-31 1991-05-07 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Macromolecular crystal growing system
JP2740375B2 (ja) * 1990-10-25 1998-04-15 富士通株式会社 生体高分子結晶化装置
US5641681A (en) * 1995-04-17 1997-06-24 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Device and method for screening crystallization conditions in solution crystal growth
WO1998002601A1 (fr) * 1996-07-15 1998-01-22 Sumitomo Metal Industries, Ltd. Equipement de croissance de cristaux et procede pour la croissance de cristaux utilisant cet equipement
US5961934A (en) * 1998-02-18 1999-10-05 Biospace International Inc. Dynamically controlled crystallization method and apparatus and crystals obtained thereby

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8403888B2 (en) 2010-04-15 2013-03-26 Teneo Innovations Inc. Device and electronic controller for syringe piston control

Also Published As

Publication number Publication date
GB2384729A (en) 2003-08-06
WO2002026342A1 (fr) 2002-04-04
EP1444023A1 (fr) 2004-08-11
GB0309333D0 (en) 2003-06-04
AU2002211293A1 (en) 2002-04-08
WO2002026342A9 (fr) 2004-04-22

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued
FZDE Discontinued

Effective date: 20070928