GB2384729A - Automated robotic device for dynamically controlled crystallization of proteins - Google Patents
Automated robotic device for dynamically controlled crystallization of proteinsInfo
- Publication number
- GB2384729A GB2384729A GB0309333A GB0309333A GB2384729A GB 2384729 A GB2384729 A GB 2384729A GB 0309333 A GB0309333 A GB 0309333A GB 0309333 A GB0309333 A GB 0309333A GB 2384729 A GB2384729 A GB 2384729A
- Authority
- GB
- United Kingdom
- Prior art keywords
- robotic device
- proteins
- reagent
- dynamically controlled
- automated robotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N25/00—Investigating or analyzing materials by the use of thermal means
- G01N25/14—Investigating or analyzing materials by the use of thermal means by using distillation, extraction, sublimation, condensation, freezing, or crystallisation
- G01N25/147—Investigating or analyzing materials by the use of thermal means by using distillation, extraction, sublimation, condensation, freezing, or crystallisation by cristallisation
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
- C30B29/54—Organic compounds
- C30B29/58—Macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Abstract
Apparatus and methods are provided for independently controlling dynamic, reagent-induced transformations of multiple samples including proteins being crystallized and cells being cultured. The invention provides an automatic robotic device that enhances protein crystallization in high-throughput, using reagent reservoirs (28) linked to reagent chambers (40), with sample chambers (44) communicating with the reagent chambers (40) via semipermeable membrane.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23592800P | 2000-09-28 | 2000-09-28 | |
US23592300P | 2000-09-28 | 2000-09-28 | |
US23592200P | 2000-09-28 | 2000-09-28 | |
US23592700P | 2000-09-28 | 2000-09-28 | |
PCT/US2001/030454 WO2002026342A1 (en) | 2000-09-28 | 2001-09-28 | Automated robotic device for dynamically controlled crystallization of proteins |
Publications (2)
Publication Number | Publication Date |
---|---|
GB0309333D0 GB0309333D0 (en) | 2003-06-04 |
GB2384729A true GB2384729A (en) | 2003-08-06 |
Family
ID=27499824
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB0309333A Withdrawn GB2384729A (en) | 2000-09-28 | 2001-09-28 | Automated robotic device for dynamically controlled crystallization of proteins |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1444023A1 (en) |
AU (1) | AU2002211293A1 (en) |
CA (1) | CA2424033A1 (en) |
GB (1) | GB2384729A (en) |
WO (1) | WO2002026342A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6818060B2 (en) | 1999-08-02 | 2004-11-16 | Emerald Biostructures, Inc. | Robot for mixing crystallization trial matrices |
US6860940B2 (en) | 2002-02-11 | 2005-03-01 | The Regents Of The University Of California | Automated macromolecular crystallization screening |
US7463982B2 (en) | 2004-12-22 | 2008-12-09 | Lawrence Livermore National Security, Llc | Liquid class predictor for liquid handling of complex mixtures |
CA2736841C (en) | 2010-04-15 | 2014-02-18 | Teneo Innovations Inc. | Device and electronic controller for syringe piston control |
GB2554334A (en) | 2016-05-17 | 2018-04-04 | Tap Biosystems Phc Ltd | Automated bioprocess development |
JP6797717B2 (en) | 2017-03-02 | 2020-12-09 | 千代田化工建設株式会社 | Protein crystallization method and crystallization equipment |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4755363A (en) * | 1985-10-30 | 1988-07-05 | Fujitsu Limited | Automated biopolymer crystal preparation apparatus |
US4917707A (en) * | 1986-10-09 | 1990-04-17 | Aerospatiale Societe Nationale Industrielle | Process, cell and device for crystal growth, particularly for space vessel |
US5013531A (en) * | 1990-08-31 | 1991-05-07 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Macromolecular crystal growing system |
US5362325A (en) * | 1990-10-25 | 1994-11-08 | Fujitsu Limited | Apparatus for growing crystals in an environment in which opportunity for accessing is limited |
US5641681A (en) * | 1995-04-17 | 1997-06-24 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Device and method for screening crystallization conditions in solution crystal growth |
US5961934A (en) * | 1998-02-18 | 1999-10-05 | Biospace International Inc. | Dynamically controlled crystallization method and apparatus and crystals obtained thereby |
US6174365B1 (en) * | 1996-07-15 | 2001-01-16 | Sumitomo Metal Industries, Ltd. | Apparatus for crystal growth and crystal growth method employing the same |
-
2001
- 2001-09-28 AU AU2002211293A patent/AU2002211293A1/en not_active Abandoned
- 2001-09-28 CA CA002424033A patent/CA2424033A1/en not_active Abandoned
- 2001-09-28 GB GB0309333A patent/GB2384729A/en not_active Withdrawn
- 2001-09-28 EP EP01979319A patent/EP1444023A1/en not_active Withdrawn
- 2001-09-28 WO PCT/US2001/030454 patent/WO2002026342A1/en not_active Application Discontinuation
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4755363A (en) * | 1985-10-30 | 1988-07-05 | Fujitsu Limited | Automated biopolymer crystal preparation apparatus |
US4917707A (en) * | 1986-10-09 | 1990-04-17 | Aerospatiale Societe Nationale Industrielle | Process, cell and device for crystal growth, particularly for space vessel |
US5013531A (en) * | 1990-08-31 | 1991-05-07 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Macromolecular crystal growing system |
US5362325A (en) * | 1990-10-25 | 1994-11-08 | Fujitsu Limited | Apparatus for growing crystals in an environment in which opportunity for accessing is limited |
US5641681A (en) * | 1995-04-17 | 1997-06-24 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Device and method for screening crystallization conditions in solution crystal growth |
US6174365B1 (en) * | 1996-07-15 | 2001-01-16 | Sumitomo Metal Industries, Ltd. | Apparatus for crystal growth and crystal growth method employing the same |
US5961934A (en) * | 1998-02-18 | 1999-10-05 | Biospace International Inc. | Dynamically controlled crystallization method and apparatus and crystals obtained thereby |
Also Published As
Publication number | Publication date |
---|---|
EP1444023A1 (en) | 2004-08-11 |
WO2002026342A9 (en) | 2004-04-22 |
CA2424033A1 (en) | 2002-04-04 |
AU2002211293A1 (en) | 2002-04-08 |
WO2002026342A1 (en) | 2002-04-04 |
GB0309333D0 (en) | 2003-06-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |