GB2384729A - Automated robotic device for dynamically controlled crystallization of proteins - Google Patents

Automated robotic device for dynamically controlled crystallization of proteins

Info

Publication number
GB2384729A
GB2384729A GB0309333A GB0309333A GB2384729A GB 2384729 A GB2384729 A GB 2384729A GB 0309333 A GB0309333 A GB 0309333A GB 0309333 A GB0309333 A GB 0309333A GB 2384729 A GB2384729 A GB 2384729A
Authority
GB
United Kingdom
Prior art keywords
robotic device
proteins
reagent
dynamically controlled
automated robotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0309333A
Other versions
GB0309333D0 (en
Inventor
Leonard Arnowitz
Emmanuel Steinberg
Michael T Harris
Iii Thomas C S Keller
Mark W Sawicki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BSI Proteomics Corp
Original Assignee
BSI Proteomics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BSI Proteomics Corp filed Critical BSI Proteomics Corp
Publication of GB0309333D0 publication Critical patent/GB0309333D0/en
Publication of GB2384729A publication Critical patent/GB2384729A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00—Investigating or analyzing materials by the use of thermal means
    • G01N25/14—Investigating or analyzing materials by the use of thermal means by using distillation, extraction, sublimation, condensation, freezing, or crystallisation
    • G01N25/147—Investigating or analyzing materials by the use of thermal means by using distillation, extraction, sublimation, condensation, freezing, or crystallisation by cristallisation
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C30B29/58—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

Apparatus and methods are provided for independently controlling dynamic, reagent-induced transformations of multiple samples including proteins being crystallized and cells being cultured. The invention provides an automatic robotic device that enhances protein crystallization in high-throughput, using reagent reservoirs (28) linked to reagent chambers (40), with sample chambers (44) communicating with the reagent chambers (40) via semipermeable membrane.
GB0309333A 2000-09-28 2001-09-28 Automated robotic device for dynamically controlled crystallization of proteins Withdrawn GB2384729A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US23592800P 2000-09-28 2000-09-28
US23592300P 2000-09-28 2000-09-28
US23592200P 2000-09-28 2000-09-28
US23592700P 2000-09-28 2000-09-28
PCT/US2001/030454 WO2002026342A1 (en) 2000-09-28 2001-09-28 Automated robotic device for dynamically controlled crystallization of proteins

Publications (2)

Publication Number Publication Date
GB0309333D0 GB0309333D0 (en) 2003-06-04
GB2384729A true GB2384729A (en) 2003-08-06

Family

ID=27499824

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0309333A Withdrawn GB2384729A (en) 2000-09-28 2001-09-28 Automated robotic device for dynamically controlled crystallization of proteins

Country Status (5)

Country Link
EP (1) EP1444023A1 (en)
AU (1) AU2002211293A1 (en)
CA (1) CA2424033A1 (en)
GB (1) GB2384729A (en)
WO (1) WO2002026342A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818060B2 (en) 1999-08-02 2004-11-16 Emerald Biostructures, Inc. Robot for mixing crystallization trial matrices
US6860940B2 (en) 2002-02-11 2005-03-01 The Regents Of The University Of California Automated macromolecular crystallization screening
US7463982B2 (en) 2004-12-22 2008-12-09 Lawrence Livermore National Security, Llc Liquid class predictor for liquid handling of complex mixtures
CA2736841C (en) 2010-04-15 2014-02-18 Teneo Innovations Inc. Device and electronic controller for syringe piston control
GB2554334A (en) 2016-05-17 2018-04-04 Tap Biosystems Phc Ltd Automated bioprocess development
JP6797717B2 (en) 2017-03-02 2020-12-09 千代田化工建設株式会社 Protein crystallization method and crystallization equipment

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4755363A (en) * 1985-10-30 1988-07-05 Fujitsu Limited Automated biopolymer crystal preparation apparatus
US4917707A (en) * 1986-10-09 1990-04-17 Aerospatiale Societe Nationale Industrielle Process, cell and device for crystal growth, particularly for space vessel
US5013531A (en) * 1990-08-31 1991-05-07 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Macromolecular crystal growing system
US5362325A (en) * 1990-10-25 1994-11-08 Fujitsu Limited Apparatus for growing crystals in an environment in which opportunity for accessing is limited
US5641681A (en) * 1995-04-17 1997-06-24 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Device and method for screening crystallization conditions in solution crystal growth
US5961934A (en) * 1998-02-18 1999-10-05 Biospace International Inc. Dynamically controlled crystallization method and apparatus and crystals obtained thereby
US6174365B1 (en) * 1996-07-15 2001-01-16 Sumitomo Metal Industries, Ltd. Apparatus for crystal growth and crystal growth method employing the same

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4755363A (en) * 1985-10-30 1988-07-05 Fujitsu Limited Automated biopolymer crystal preparation apparatus
US4917707A (en) * 1986-10-09 1990-04-17 Aerospatiale Societe Nationale Industrielle Process, cell and device for crystal growth, particularly for space vessel
US5013531A (en) * 1990-08-31 1991-05-07 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Macromolecular crystal growing system
US5362325A (en) * 1990-10-25 1994-11-08 Fujitsu Limited Apparatus for growing crystals in an environment in which opportunity for accessing is limited
US5641681A (en) * 1995-04-17 1997-06-24 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Device and method for screening crystallization conditions in solution crystal growth
US6174365B1 (en) * 1996-07-15 2001-01-16 Sumitomo Metal Industries, Ltd. Apparatus for crystal growth and crystal growth method employing the same
US5961934A (en) * 1998-02-18 1999-10-05 Biospace International Inc. Dynamically controlled crystallization method and apparatus and crystals obtained thereby

Also Published As

Publication number Publication date
EP1444023A1 (en) 2004-08-11
WO2002026342A9 (en) 2004-04-22
CA2424033A1 (en) 2002-04-04
AU2002211293A1 (en) 2002-04-08
WO2002026342A1 (en) 2002-04-04
GB0309333D0 (en) 2003-06-04

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)