CA2419851A1 - Demonstration genetique du besoin de nkx6.1, nkx2.2 et nkx6.2 pour la production de neurones ventraux - Google Patents
Demonstration genetique du besoin de nkx6.1, nkx2.2 et nkx6.2 pour la production de neurones ventraux Download PDFInfo
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- CA2419851A1 CA2419851A1 CA002419851A CA2419851A CA2419851A1 CA 2419851 A1 CA2419851 A1 CA 2419851A1 CA 002419851 A CA002419851 A CA 002419851A CA 2419851 A CA2419851 A CA 2419851A CA 2419851 A1 CA2419851 A1 CA 2419851A1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention concerne un procédé permettant de transformer une cellule embryonnaire en un neurone ventral. Ce procédé consiste à introduire dans la cellule embryonnaire un acide nucléique exprimant la protéine Nkx6.1 ou Nkx6.2 de facteur de transcription à homéodomaine dans la cellule embryonnaire, de manière à transformer la cellule embryonnaire en un neurone ventral. La présente invention concerne des méthodes permettant de diagnostiquer une maladie dégénérative du motoneurone chez un sujet. L'invention concerne également des méthodes permettant de traiter la dégénérescence neuronale chez un sujet, consistant à implanter, dans un tissu neural malade du sujet, une cellule embryonnaire neurale comprenant une molécule d'acide nucléique isolée pouvant exprimer la protéine Nkx6.1 ou Nkx6.2 à homéodomaine dans des conditions telles que la cellule embryonnaire est transformée en un motoneurone après implantation, ce qui permet de traiter la dégénérescence neuronale chez le sujet.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/654,462 US7393686B1 (en) | 2000-05-11 | 2000-09-01 | Genetic demonstration of requirement for NKX6.1 and NKX2.2 in ventral neuron generation |
| US09/654,462 | 2000-09-01 | ||
| PCT/US2001/027256 WO2002018545A1 (fr) | 2000-09-01 | 2001-08-31 | Demonstration genetique du besoin de nkx6.1, nkx2.2 et nkx6.2 pour la production de neurones ventraux |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2419851A1 true CA2419851A1 (fr) | 2002-03-07 |
Family
ID=24624954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002419851A Abandoned CA2419851A1 (fr) | 2000-09-01 | 2001-08-31 | Demonstration genetique du besoin de nkx6.1, nkx2.2 et nkx6.2 pour la production de neurones ventraux |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1315794A4 (fr) |
| AU (1) | AU2001288634A1 (fr) |
| CA (1) | CA2419851A1 (fr) |
| WO (1) | WO2002018545A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7312081B2 (en) | 2000-05-11 | 2007-12-25 | The Trustees Of Columbia University In The City Of New York | Genetic demonstration of requirement for nkx6.1, nkx2.2 and nkx6.2 in ventral neuron generation |
| US7393686B1 (en) | 2000-05-11 | 2008-07-01 | Trustees Of Columbia University In The City Of New York | Genetic demonstration of requirement for NKX6.1 and NKX2.2 in ventral neuron generation |
| US6955802B1 (en) | 2000-05-11 | 2005-10-18 | The Trustees Of Columbia University In The City Of New York | Homeodomain protein code specifying progenitor cell identify and neuronal fate in the ventral neural tube |
| US20100319073A1 (en) * | 2005-09-29 | 2010-12-16 | The Johns Hopkins University | GDE Compositions and Methods |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995023223A1 (fr) * | 1994-02-25 | 1995-08-31 | The Trustees Of Columbia University In The City Of New York | Adn codant un homologue vertebre de 'hedgehog', vhh-1, exprime par la notocorde, et ses utilisations |
| DE19726966C1 (de) * | 1997-06-25 | 1999-01-28 | Flachglas Ag | Verfahren zur Herstellung einer transparenten Silberschicht mit hoher spezifischer elektrischer Leitfähigkeit , Glasscheibe mit einem Dünnschichtsystem mit einer solchen Silberschicht und deren Verwendung |
| GB9713469D0 (en) * | 1997-06-25 | 1997-09-03 | Medical Res Council | Neuronal stem cell gene |
| CA2339303A1 (fr) * | 1998-08-14 | 2000-02-24 | California Institute Of Technology | Methodes de formation de neurones |
| US6387656B1 (en) * | 1998-09-29 | 2002-05-14 | The Trustees Of Columbia University In The City Of New York | Gene encoding MNR2 and uses thereof |
-
2001
- 2001-08-31 AU AU2001288634A patent/AU2001288634A1/en not_active Abandoned
- 2001-08-31 EP EP01968382A patent/EP1315794A4/fr not_active Withdrawn
- 2001-08-31 CA CA002419851A patent/CA2419851A1/fr not_active Abandoned
- 2001-08-31 WO PCT/US2001/027256 patent/WO2002018545A1/fr active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002018545A1 (fr) | 2002-03-07 |
| EP1315794A4 (fr) | 2005-01-26 |
| EP1315794A1 (fr) | 2003-06-04 |
| AU2001288634A1 (en) | 2002-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |