CA2417917C - Systemes et procedes permettant d'obtenir des informations concernant des chromophores presents dans des milieux physiologiques - Google Patents

Systemes et procedes permettant d'obtenir des informations concernant des chromophores presents dans des milieux physiologiques Download PDF

Info

Publication number
CA2417917C
CA2417917C CA2417917A CA2417917A CA2417917C CA 2417917 C CA2417917 C CA 2417917C CA 2417917 A CA2417917 A CA 2417917A CA 2417917 A CA2417917 A CA 2417917A CA 2417917 C CA2417917 C CA 2417917C
Authority
CA
Canada
Prior art keywords
wave
optical probe
detectors
scanning
scanning unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2417917A
Other languages
English (en)
Other versions
CA2417917A1 (fr
Inventor
Xuefeng Cheng
Xiaorong Xu
Shuoming Zhou
Lai Wang
Ming Wang
Feng Li
Guobao Hu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ViOptix Inc
Original Assignee
ViOptix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/664,972 external-priority patent/US6597931B1/en
Priority claimed from US09/778,613 external-priority patent/US20020035317A1/en
Priority claimed from US09/778,617 external-priority patent/US20020033454A1/en
Priority claimed from US09/778,618 external-priority patent/US6516209B2/en
Priority claimed from US09/778,614 external-priority patent/US6801648B2/en
Priority claimed from US09/877,515 external-priority patent/US6587703B2/en
Priority to CA2852980A priority Critical patent/CA2852980C/fr
Application filed by ViOptix Inc filed Critical ViOptix Inc
Publication of CA2417917A1 publication Critical patent/CA2417917A1/fr
Publication of CA2417917C publication Critical patent/CA2417917C/fr
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0242—Special features of optical sensors or probes classified in A61B5/00 for varying or adjusting the optical path length in the tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/043—Arrangements of multiple sensors of the same type in a linear array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/046—Arrangements of multiple sensors of the same type in a matrix array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14552—Details of sensors specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/413—Monitoring transplanted tissue or organ, e.g. for possible rejection reactions after a transplant
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
    • G01N2021/3144—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths for oxymetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid

Abstract

De manière générale, la présente invention concerne des systèmes et des procédés permettant d'obtenir des informations concernant des chromophores présents dans des milieux physiologiques. Plus particulièrement, l'invention concerne des systèmes et des procédés non invasifs destinés à déterminer des valeurs absolues se rapportant à des hémoglobines oxygénées et/ou désoxygénées ainsi que leurs rapports dans un milieu physiologique. Dans un mode de réalisation préféré, ce système est généralement équipé d'une sonde portable comprenant un module source servant à produire un rayonnement électromagnétique dans un milieu, un module de détection permettant de détecter ce rayonnement à partir d'une zone cible dans ce milieu, ainsi qu'un module de traitement déterminant les valeurs absolues des concentrations des chromophores ainsi que leurs rapports sur la base des paramètres d'entrée et de sortie du module source et du module de détection. Dans un mode de réalisation, l'invention permet d'obtenir une solution pour les paramètres inconnus des chromophores contenus dans un milieu grâce à l'utilisation d'un nouvel algorithme de traitement. Dans un autre mode de réalisation, l'invention concerne une unité portable destinée à effectuer des mesures nécessaires, cette unité étant dotée d'un élément mobile comportant une ou plusieurs sources de rayonnement et un ou plusieurs détecteurs de rayonnement ainsi qu'un actionneur conçu pour amener ledit élément à se déplacer sur des trajets curvilignes prédéterminés. On mesure les propriétés de ces chromophores pour des voxels individuels définis sur chaque trajet de mouvement et/ou pour des voxels transversaux définis au niveau des intersections des voxels sur les différents trajets de mouvement. Dans un mode de réalisation préféré, on utilise alors ces valeurs mesurées pour produire des images bi- ou tridimensionnelles de la répartition des chromophores ou de leurs propriétés. Dans d'autres modes de réalisation, l'invention fait intervenir différents modèles destinés à une répartition optimale des sources et des détecteurs pour la sonde optique, ainsi qu'une opération d'auto-étalonnage de la sonde exécutée pratiquement en temps réel.
CA2417917A 2000-08-04 2001-08-03 Systemes et procedes permettant d'obtenir des informations concernant des chromophores presents dans des milieux physiologiques Expired - Lifetime CA2417917C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2852980A CA2852980C (fr) 2000-08-04 2001-08-03 Systemes et procedes permettant d'obtenir des informations concernant des chromophores presents dans des milieux physiologiques

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US22281600P 2000-08-04 2000-08-04
US22307400P 2000-08-04 2000-08-04
US60/222,816 2000-08-04
US60/223,074 2000-08-04
US09/664,972 2000-09-18
US09/664,972 US6597931B1 (en) 2000-09-18 2000-09-18 System and method for absolute oxygen saturation
US09/778,613 2001-02-06
US09/778,617 US20020033454A1 (en) 2000-08-04 2001-02-06 Optical imaging system with direct image construction
US09/778,618 US6516209B2 (en) 2000-08-04 2001-02-06 Self-calibrating optical imaging system
US09/778,614 US6801648B2 (en) 2000-08-04 2001-02-06 Optical imaging system with symmetric optical probe
US09/778,618 2001-02-06
US09/778,614 2001-02-06
US09/778,617 2001-02-06
US09/778,613 US20020035317A1 (en) 2000-08-04 2001-02-06 Optical imaging system with movable scanning unit
US09/877,515 2001-06-07
US09/877,515 US6587703B2 (en) 2000-09-18 2001-06-07 System and method for measuring absolute oxygen saturation
PCT/US2001/024301 WO2002012854A2 (fr) 2000-08-04 2001-08-03 Systemes et procedes permettant d'obtenir des informations concernant des chromophores presents dans des milieux physiologiques

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2852980A Division CA2852980C (fr) 2000-08-04 2001-08-03 Systemes et procedes permettant d'obtenir des informations concernant des chromophores presents dans des milieux physiologiques

Publications (2)

Publication Number Publication Date
CA2417917A1 CA2417917A1 (fr) 2002-02-14
CA2417917C true CA2417917C (fr) 2014-10-14

Family

ID=27575220

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2417917A Expired - Lifetime CA2417917C (fr) 2000-08-04 2001-08-03 Systemes et procedes permettant d'obtenir des informations concernant des chromophores presents dans des milieux physiologiques

Country Status (4)

Country Link
EP (1) EP1307135A4 (fr)
AU (1) AU2001281005A1 (fr)
CA (1) CA2417917C (fr)
WO (1) WO2002012854A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7551950B2 (en) 2004-06-29 2009-06-23 O2 Medtech, Inc,. Optical apparatus and method of use for non-invasive tomographic scan of biological tissues
US8249696B2 (en) 2007-12-19 2012-08-21 Depuy Spine, Inc. Smart pedicle tool
CA2833258A1 (fr) 2011-04-15 2012-10-18 Constitution Medical, Inc. Mesure du volume et des constituants de cellules
EP3570743A4 (fr) * 2017-01-18 2020-11-11 Optican Systems Inc. Sonde portative et système d'imagerie de tissu biologique humain
WO2020239922A1 (fr) * 2019-05-28 2020-12-03 Universität Zürich Appareil optique comprenant deux ensembles de mesures optiques auto-calibrées
CN111929655B (zh) * 2020-09-08 2023-07-14 中国电子科技集团公司第三十八研究所 一种汽车毫米波雷达道路目标跟踪方法及系统

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06103257B2 (ja) * 1988-12-19 1994-12-14 大塚電子株式会社 光散乱を用いた物質の吸光係数測定方法および装置
IL107396A (en) * 1992-11-09 1997-02-18 Boehringer Mannheim Gmbh Method and apparatus for analytical determination of glucose in a biological matrix
US5987346A (en) * 1993-02-26 1999-11-16 Benaron; David A. Device and method for classification of tissue
JP3433498B2 (ja) * 1993-06-02 2003-08-04 浜松ホトニクス株式会社 散乱吸収体の内部情報計測方法及び装置
US5803909A (en) * 1994-10-06 1998-09-08 Hitachi, Ltd. Optical system for measuring metabolism in a body and imaging method
US6104945A (en) * 1995-08-01 2000-08-15 Medispectra, Inc. Spectral volume microprobe arrays
US6088605A (en) * 1996-02-23 2000-07-11 Diasense, Inc. Method and apparatus for non-invasive blood glucose sensing
JPH11244267A (ja) * 1998-03-03 1999-09-14 Fuji Photo Film Co Ltd 血中成分濃度測定装置
US6078833A (en) * 1998-03-25 2000-06-20 I.S.S. (Usa) Inc. Self referencing photosensor

Also Published As

Publication number Publication date
EP1307135A2 (fr) 2003-05-07
WO2002012854A9 (fr) 2002-10-17
AU2001281005A1 (en) 2002-02-18
WO2002012854A3 (fr) 2002-12-19
CA2417917A1 (fr) 2002-02-14
EP1307135A4 (fr) 2006-05-31
WO2002012854A2 (fr) 2002-02-14

Similar Documents

Publication Publication Date Title
US6801648B2 (en) Optical imaging system with symmetric optical probe
Binzoni et al. The use of the Henyey–Greenstein phase function in Monte Carlo simulations in biomedical optics
Zhao et al. Maps of optical differential pathlength factor of human adult forehead, somatosensory motor and occipital regions at multi-wavelengths in NIR
US5137355A (en) Method of imaging a random medium
EP0710832B1 (fr) Procédé et appareil pour mesurer les caractéristiques de diffusion et d'absorption d'un milieu diffusant
US5678556A (en) Imaging method for spatial distributions of absorber concentrations
Wardell et al. Laser Doppler perfusion imaging by dynamic light scattering
EP0592200B1 (fr) Procédé et appareil pour mesurer d'information optique dans un milieu diffusant
CA2319454A1 (fr) Detection, visualisation et caracterisation de carcinomes mammaires
WO1997043950A1 (fr) Appareil de visualisation de l'ecoulement sanguin dans des vaisseaux de petit calibre
Florescu et al. Single-scattering optical tomography
KR20100126302A (ko) 3차원 물체의 공간-비색 측정 장치 및 방법
JPH0894517A (ja) 散乱吸収体の吸収成分の濃度計測方法及び装置
CA2417917C (fr) Systemes et procedes permettant d'obtenir des informations concernant des chromophores presents dans des milieux physiologiques
EP0419573B1 (fr) Procede d'imagerie d'un milieu aleatoire
Zuo et al. Spectral crosstalk in photoacoustic computed tomography
CN103908239B (zh) 非接触式成像系统及其成像方法
JP5658979B2 (ja) 生体光計測装置及び生体における吸収係数の変動を推定する方法
JP2004534934A (ja) 生理学的媒体中の発色団に関する情報を与えるためのシステム及び方法
Dyatlov et al. The scanning flow cytometer modified for measurement of two-dimensional light-scattering pattern of individual particles
JP3730927B2 (ja) 吸収物質濃度空間分布画像化装置
Chance et al. Photon dynamics in tissue imaging
Poupinet et al. Heterodyne detection for measuring extinction coefficient in mammalian tissue
JP2012005556A (ja) 生体機能情報の光計測装置
TWI439963B (zh) 擴散光學斷層掃瞄之重疊／組合影像重建方法、裝置及程式產品

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20210803

MKEX Expiry

Effective date: 20210803