CA2417917C - Systems and methods for providing information concerning chromophores in physiological media - Google Patents

Systems and methods for providing information concerning chromophores in physiological media Download PDF

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Publication number
CA2417917C
CA2417917C CA 2417917 CA2417917A CA2417917C CA 2417917 C CA2417917 C CA 2417917C CA 2417917 CA2417917 CA 2417917 CA 2417917 A CA2417917 A CA 2417917A CA 2417917 C CA2417917 C CA 2417917C
Authority
CA
Canada
Prior art keywords
chromophores
medium
methods
systems
radiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA 2417917
Other languages
French (fr)
Other versions
CA2417917A1 (en
Inventor
Xuefeng Cheng
Xiaorong Xu
Shuoming Zhou
Lai Wang
Ming Wang
Feng Li
Guobao Hu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ViOptix Inc
Original Assignee
ViOptix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US22307400P priority Critical
Priority to US22281600P priority
Priority to US60/223,074 priority
Priority to US60/222,816 priority
Priority to US09/664,972 priority patent/US6597931B1/en
Priority to US09/664,972 priority
Priority to US09/778,614 priority
Priority to US09/778,613 priority
Priority to US09/778,618 priority
Priority to US09/778,617 priority patent/US20020033454A1/en
Priority to US09/778,617 priority
Priority to US09/778,618 priority patent/US6516209B2/en
Priority to US09/778,614 priority patent/US6801648B2/en
Priority to US09/778,613 priority patent/US20020035317A1/en
Priority to US09/877,515 priority patent/US6587703B2/en
Priority to US09/877,515 priority
Priority claimed from CA2852980A external-priority patent/CA2852980C/en
Application filed by ViOptix Inc filed Critical ViOptix Inc
Priority to PCT/US2001/024301 priority patent/WO2002012854A2/en
Publication of CA2417917A1 publication Critical patent/CA2417917A1/en
Publication of CA2417917C publication Critical patent/CA2417917C/en
Application granted granted Critical
Application status is Active legal-status Critical
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233Special features of optical sensors or probes classified in A61B5/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0242Special features of optical sensors or probes classified in A61B5/00 for varying or adjusting the optical path length in the tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04Arrangements of multiple sensors of the same type
    • A61B2562/043Arrangements of multiple sensors of the same type in a linear array
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04Arrangements of multiple sensors of the same type
    • A61B2562/046Arrangements of multiple sensors of the same type in a matrix array
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14552Details of sensors specially adapted therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14553Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/41Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/413Monitoring transplanted tissue or organ, e.g. for possible rejection reactions after a transplant
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/314Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
    • G01N2021/3144Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths for oxymetry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infra-red light
    • G01N21/359Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infra-red light using near infra-red light
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/49Scattering, i.e. diffuse reflection within a body or fluid

Abstract

The present invention generally relates to systems and methods for providing information about chromophores in physiological media. More particularly, the invention relates to non-invasive systems and methods for determining absolute values of oxygenated and/or deoxygenated hemoglobins and their ratios in a physiological medium. The system generally includes a portable probe having a source module (122) for irradiating into the medium electromagnetic radiation, a detector module (124) detecting radiation from a target area in the medium, and a processing module (140) determining the absolute values of the chromophore concentrations and the ratios thereof based on input and output parameters of the source and detector modules. In one aspect, the invention provides a solution for unknown parameters of the chromophores in a medium using a novel processing algorithm. In another aspect, the invention concerns a portable unit for performing the requisite measurements, which unit includes a movable member having one or more radiation sources and one or more radiation detectors, and an actuator designed to cause the member to move along predetermined curvilinear paths. Properties of the chromophores are measured for individual voxels defined along each motion path, and/or cross-voxels defined at the intersection of voxels along different motion paths.
These measured values are then used in a preferred embodiment to generate two-or three-dimensional images of the distribution of chromophores or their properties. In other aspects, the invention includes various patterns for the optimal distribution of sources and detectors for the optical probe, and self-calibrating operation of the probe substantially in real-time.
CA 2417917 2000-08-04 2001-08-03 Systems and methods for providing information concerning chromophores in physiological media Active CA2417917C (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
US22307400P true 2000-08-04 2000-08-04
US22281600P true 2000-08-04 2000-08-04
US60/223,074 2000-08-04
US60/222,816 2000-08-04
US09/664,972 US6597931B1 (en) 2000-09-18 2000-09-18 System and method for absolute oxygen saturation
US09/664,972 2000-09-18
US09/778,618 2001-02-06
US09/778,617 US20020033454A1 (en) 2000-08-04 2001-02-06 Optical imaging system with direct image construction
US09/778,617 2001-02-06
US09/778,618 US6516209B2 (en) 2000-08-04 2001-02-06 Self-calibrating optical imaging system
US09/778,614 US6801648B2 (en) 2000-08-04 2001-02-06 Optical imaging system with symmetric optical probe
US09/778,613 US20020035317A1 (en) 2000-08-04 2001-02-06 Optical imaging system with movable scanning unit
US09/778,614 2001-02-06
US09/778,613 2001-02-06
US09/877,515 2001-06-07
US09/877,515 US6587703B2 (en) 2000-09-18 2001-06-07 System and method for measuring absolute oxygen saturation
PCT/US2001/024301 WO2002012854A2 (en) 2000-08-04 2001-08-03 Systems and methods for providing information concerning chromophores in physiological media

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA2852980A CA2852980C (en) 2000-08-04 2001-08-03 Systems and methods for providing information concerning chromophores in physiological media

Publications (2)

Publication Number Publication Date
CA2417917A1 CA2417917A1 (en) 2002-02-14
CA2417917C true CA2417917C (en) 2014-10-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2417917 Active CA2417917C (en) 2000-08-04 2001-08-03 Systems and methods for providing information concerning chromophores in physiological media

Country Status (4)

Country Link
EP (1) EP1307135A4 (en)
AU (1) AU8100501A (en)
CA (1) CA2417917C (en)
WO (1) WO2002012854A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7551950B2 (en) 2004-06-29 2009-06-23 O2 Medtech, Inc,. Optical apparatus and method of use for non-invasive tomographic scan of biological tissues
US8249696B2 (en) 2007-12-19 2012-08-21 Depuy Spine, Inc. Smart pedicle tool
CN107402178A (en) 2011-04-15 2017-11-28 罗氏血液诊断股份有限公司 Measure cell volume and composition

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06103257B2 (en) * 1988-12-19 1994-12-14 大塚電子株式会社 Extinction coefficient measuring method and apparatus for materials using light scattering
IL107396A (en) * 1992-11-09 1997-02-18 Boehringer Mannheim Gmbh Method and apparatus for analytical determination of glucose in a biological matrix
US5987346A (en) * 1993-02-26 1999-11-16 Benaron; David A. Device and method for classification of tissue
JP3433498B2 (en) * 1993-06-02 2003-08-04 浜松ホトニクス株式会社 Internal information measuring method and apparatus of scattering medium
US5803909A (en) * 1994-10-06 1998-09-08 Hitachi, Ltd. Optical system for measuring metabolism in a body and imaging method
US6104945A (en) * 1995-08-01 2000-08-15 Medispectra, Inc. Spectral volume microprobe arrays
WO1997030629A1 (en) * 1996-02-23 1997-08-28 Diasense, Inc. Method and apparatus for non-invasive blood glucose sensing
JPH11244267A (en) * 1998-03-03 1999-09-14 Fuji Photo Film Co Ltd Blood component concentration measuring device
US6078833A (en) * 1998-03-25 2000-06-20 I.S.S. (Usa) Inc. Self referencing photosensor

Also Published As

Publication number Publication date
CA2417917A1 (en) 2002-02-14
EP1307135A2 (en) 2003-05-07
EP1307135A4 (en) 2006-05-31
AU8100501A (en) 2002-02-18
WO2002012854A9 (en) 2002-10-17
WO2002012854A3 (en) 2002-12-19
WO2002012854A2 (en) 2002-02-14

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