CA2412847A1 - Compositions de therapie genique renfermant deux genes recombines, et methodes d'utilisation correspondantes - Google Patents
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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Abstract
La présente invention concerne de nouvelles compositions et méthodes destinées au traitement des maladies cardiovasculaires. L'invention concerne, en particulier, des compositions de thérapie génique renfermant au moins deux transgènes codant des protéines ou peptides angiogéniques. Selon un aspect de l'invention, ces deux transgènes sont véhiculés par seul vecteur d'apport de gènes. Dans un autre mode de réalisation, la composition renferme au moins deux vecteurs, chaque vecteur comprenant un transgène codant une protéine ou un peptide angiogénique différent. L'invention concerne également des méthodes de traitement des maladies cardiovasculaires utilisant lesdites compositions de thérapie génique ; des kits d'apport de gènes ; et des compositions pharmaceutiques.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60776600A | 2000-06-30 | 2000-06-30 | |
| US09/607,766 | 2000-06-30 | ||
| US82629101A | 2001-04-03 | 2001-04-03 | |
| US09/826,291 | 2001-04-03 | ||
| PCT/US2001/021059 WO2002002148A2 (fr) | 2000-06-30 | 2001-06-28 | Compositions de therapie genique renfermant deux genes recombines, et methodes d'utilisation correspondantes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2412847A1 true CA2412847A1 (fr) | 2002-01-10 |
Family
ID=27085582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002412847A Abandoned CA2412847A1 (fr) | 2000-06-30 | 2001-06-28 | Compositions de therapie genique renfermant deux genes recombines, et methodes d'utilisation correspondantes |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1294407A2 (fr) |
| AU (1) | AU2002216751A1 (fr) |
| CA (1) | CA2412847A1 (fr) |
| WO (1) | WO2002002148A2 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001291019A1 (en) | 2000-09-15 | 2002-03-26 | Genvec, Inc. | Method of modulating neovascularization |
| US20020164310A1 (en) * | 2001-03-02 | 2002-11-07 | Mgvs Ltd. | Nucleic acid constructs, cells transformed therewith and methods utilizing same for inducing liver regeneration and alleviation of portal hypertension |
| ES2222782B1 (es) * | 2002-09-13 | 2006-03-01 | Advanced In Vitro Cell Technoligies, S.L. | Metodo para la obtencion de un modelo celular singular capaz de reproducir in vitro la idiosincrasia metabolica de los seres humanos. |
| US20080081354A1 (en) * | 2006-10-02 | 2008-04-03 | Cardiac Pacemakers, Inc. | Devices, vectors and methods for inducible ischemia cardioprotection |
| US9017661B2 (en) * | 2011-02-22 | 2015-04-28 | The Board Of Regents Of The University Of Texas System | Cardiac repair by reprogramming of cardiac fibroblasts into cardiomyocytes |
| US20210393805A1 (en) * | 2018-05-16 | 2021-12-23 | University Of Massachusetts | Perfusion-based delivery of recombinant aav vectors for expression of secreted proteins |
| WO2020046750A1 (fr) * | 2018-08-30 | 2020-03-05 | Photodigm, Inc. | Instrument lidar et procédé de fonctionnement d'un instrument lidar |
| US20220265858A1 (en) * | 2019-07-19 | 2022-08-25 | University Of Florida Research Foundation, Incorporated | Aav cardiac gene therapy for cardiomyopathy in humans |
| EP4077687A1 (fr) * | 2019-12-20 | 2022-10-26 | Research Institute at Nationwide Children's Hospital | Thérapie génique optimisée pour cibler un muscle dans des maladies musculaires |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69331526T2 (de) * | 1992-11-18 | 2002-10-24 | Arch Dev Corp | Adenovirus gelenkter gen-transfer zum herz- und glatten vaskularen muskel |
| JP3961019B2 (ja) * | 1995-02-28 | 2007-08-15 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 遺伝子転移媒介の血管形成療法 |
| US6013780A (en) * | 1996-09-06 | 2000-01-11 | Technion Research & Development Co. Ltd. | VEGF145 expression vectors |
| EA005157B1 (ru) * | 1997-05-06 | 2004-12-30 | Те Риджентс Оф Те Юниверсити Оф Калифорния | Методы и составы для лечения сердечной недостаточности и вентрикулярной коррекции путем доставки in vivo ангиогенных трансгенов |
| IL137765A0 (en) * | 1998-02-11 | 2001-10-31 | Univ California | Combination of a nucleic acid and a vasoactive agent for enhanced gene delivery |
| EP1016726A1 (fr) * | 1998-12-30 | 2000-07-05 | Introgene B.V. | Thérapie génique pour la promotion de l' angiogenèse |
| CA2396779A1 (fr) * | 2000-01-07 | 2001-07-12 | Stichting Klinishce Farmacologie Groningen | Therapie genique visant a stimuler l'angiogenese et/ou le traitement de l'insuffisance cardiaque |
-
2001
- 2001-06-28 CA CA002412847A patent/CA2412847A1/fr not_active Abandoned
- 2001-06-28 AU AU2002216751A patent/AU2002216751A1/en not_active Abandoned
- 2001-06-28 EP EP01984094A patent/EP1294407A2/fr not_active Withdrawn
- 2001-06-28 WO PCT/US2001/021059 patent/WO2002002148A2/fr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002002148A3 (fr) | 2002-10-17 |
| WO2002002148A2 (fr) | 2002-01-10 |
| AU2002216751A1 (en) | 2002-01-14 |
| EP1294407A2 (fr) | 2003-03-26 |
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