CA2404641A1 - Oral delivery method and composition for solid medications or dietary supplements - Google Patents
Oral delivery method and composition for solid medications or dietary supplements Download PDFInfo
- Publication number
- CA2404641A1 CA2404641A1 CA002404641A CA2404641A CA2404641A1 CA 2404641 A1 CA2404641 A1 CA 2404641A1 CA 002404641 A CA002404641 A CA 002404641A CA 2404641 A CA2404641 A CA 2404641A CA 2404641 A1 CA2404641 A1 CA 2404641A1
- Authority
- CA
- Canada
- Prior art keywords
- oral delivery
- delivery composition
- capsule
- pill
- tablet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
An oral delivery composition and method are provided for facilitating the swallowing of a solid object such as a pill, tablet, capsule or caplet. The oral delivery composition is made up of a mixture of a base liquid and at least one additive. The additive is selected and is present in the oral delivery composition in a sufficient concentration such that the oral delivery composition has improved physical properties, in comparison with the base liquid, so that when the oral delivery composition and a solid object to be swallowed by a user are administered together to the user and swallowed, the solid object is less likely to become lodged or stuck on tongue, throat, palate or oesophageal surfaces of the user, in comparison to when the base liquid and the solid object are administered together and swallowed.
Claims (23)
1. An oral delivery composition comprising:
a mixture of a base liquid and an additive or additives, wherein the additive or additives, individually or in combination, have the properties of a thickening agent, a surfactant and a lubricating agent and are selected and present in the oral delivery composition in a sufficient concentration such that the oral delivery composition has increased viscosity and wettability, in comparison with the base liquid, such that when the oral delivery composition and a solid object to be swallowed by a user are administered together to the user and swallowed, the solid object is less likely to become lodged or stuck on tongue, throat, palate or esophageal surfaces of the user, in comparison to when the base liquid and the solid object are administered together and swallowed, and wherein the oral delivery composition has a viscosity of between 10 and 20 centipoise at 36.5 °C.
a mixture of a base liquid and an additive or additives, wherein the additive or additives, individually or in combination, have the properties of a thickening agent, a surfactant and a lubricating agent and are selected and present in the oral delivery composition in a sufficient concentration such that the oral delivery composition has increased viscosity and wettability, in comparison with the base liquid, such that when the oral delivery composition and a solid object to be swallowed by a user are administered together to the user and swallowed, the solid object is less likely to become lodged or stuck on tongue, throat, palate or esophageal surfaces of the user, in comparison to when the base liquid and the solid object are administered together and swallowed, and wherein the oral delivery composition has a viscosity of between 10 and 20 centipoise at 36.5 °C.
2. A liquid oral delivery composition for facilitating the swallowing of a pill, caplet, capsule or tablet by a user, the oral delivery composition comprising:
a mixture of a base liquid and an additive or additives, wherein the additive or additives, alone or in combination, have the properties of a thickening agent, a surfactant and a lubricating agent and are selected and present in the oral delivery composition in a sufficient concentration such that the oral delivery composition has the following properties:
(1) a density that is greater than the density of the base liquid, (2) a surface tension that is less than the surface tension of the base liquid, (3) a viscosity that is greater than the viscosity of the base liquid, and is in the range of between 10 and 20 centipoise at 36.5 °C, (4) a wettability that is greater that the wettability of the base liquid, (5) a lubricity that is greater than the lubricity of the base liquid, and (6) a lower interfacial tension than the interfacial tension of the base liquid, such that when the oral delivery composition and the pill, caplet, capsule or tablet are administered together to a user and swallowed, the pill, caplet, capsule or tablet becomes wetted and engulfed by the liquid so that it is less likely to become lodged or stuck on tongue, throat, palate or esophageal surfaces of the user, in comparison to when the base liquid and the pill, caplet, tablet, or capsule are administered together and swallowed.
a mixture of a base liquid and an additive or additives, wherein the additive or additives, alone or in combination, have the properties of a thickening agent, a surfactant and a lubricating agent and are selected and present in the oral delivery composition in a sufficient concentration such that the oral delivery composition has the following properties:
(1) a density that is greater than the density of the base liquid, (2) a surface tension that is less than the surface tension of the base liquid, (3) a viscosity that is greater than the viscosity of the base liquid, and is in the range of between 10 and 20 centipoise at 36.5 °C, (4) a wettability that is greater that the wettability of the base liquid, (5) a lubricity that is greater than the lubricity of the base liquid, and (6) a lower interfacial tension than the interfacial tension of the base liquid, such that when the oral delivery composition and the pill, caplet, capsule or tablet are administered together to a user and swallowed, the pill, caplet, capsule or tablet becomes wetted and engulfed by the liquid so that it is less likely to become lodged or stuck on tongue, throat, palate or esophageal surfaces of the user, in comparison to when the base liquid and the pill, caplet, tablet, or capsule are administered together and swallowed.
3. The oral delivery composition of Claim 2 wherein the base liquid comprises water.
4. The oral delivery composition of Claim 2 wherein the base, liquid comprises a fruit juice.
5. The oral delivery composition of Claim 2 wherein the additive or additives comprise a polysaccharide and a polysorbate surfactant.
6. The oral delivery composition of Claim 2 wherein the polysaccharide is selected from the group consisting of guar, locust bean, tamarind, arabic, karaya, tragacanth, agar, algin, carrageenan, xanthan, celluloses, pectins, carboxylated algin, carboxymethyl cellulose, hydroxypropylmethyl cellulose, carboxylated pectin, carboxylated xanthan, sulfated carrageenen, sulfated furcellaran and gellan.
7. The oral delivery composition of Claim 2 wherein the additive or additives comprise a water soluble cellulosic polymer and a polyoxyethylene sorbitan fatty acid ester.
8. The oral delivery composition of Claim 2 wherein the additive or additives comprise carboxyl methyl cellulose and polyoxyethylene sorbitan monooleate.
9. The oral delivery composition of Claim 2 wherein the oral delivery composition further contains at least one of sweeteners and flavors.
10. A composition comprising the oral delivery composition of Claim 1 and an undissolved pill, caplet, capsule or tablet.
11. A composition comprising the oral delivery composition of Claim 2 and an undissolved pill, caplet, capsule or tablet.
12. A composition comprising (a) a mixture of a base liquid, carboxyl methyl cellulose and polyoxyethylene sorbitan monooleate, wherein the mixture has a viscosity between 10 and 20 centipoise at 36.5 °C, and (b) an undissolved pill, caplet, capsule or tablet.
13. A method for swallowing a pill, caplet, capsule or tablet by a user, the method comprising the steps of:
providing an oral delivery composition comprising a mixture of a base liquid and an additive or additives, wherein the additive or additives, individually or in combination, have the properties of a thickening agent, a surfactant and a lubricating agent and are selected and present in the oral delivery composition in a sufficient concentration such that the oral delivery composition has a viscosity between 10 and 20 centipoise at 36.5 °C and increased wettability, in comparison with the base liquid such that when the oral delivery composition and a pill, caplet, capsule or tablet to be swallowed by a user are administered together to the user and swallowed, the pill, caplet, capsule or tablet is less likely to become lodged or stuck on tongue, throat, palate or esophageal surfaces of the user, in comparison to when the base liquid and the pill, caplet, capsule or tablet are administered together and swallowed, and administering the pill, caplet, capsule or tablet and the oral delivery composition together to a user.
providing an oral delivery composition comprising a mixture of a base liquid and an additive or additives, wherein the additive or additives, individually or in combination, have the properties of a thickening agent, a surfactant and a lubricating agent and are selected and present in the oral delivery composition in a sufficient concentration such that the oral delivery composition has a viscosity between 10 and 20 centipoise at 36.5 °C and increased wettability, in comparison with the base liquid such that when the oral delivery composition and a pill, caplet, capsule or tablet to be swallowed by a user are administered together to the user and swallowed, the pill, caplet, capsule or tablet is less likely to become lodged or stuck on tongue, throat, palate or esophageal surfaces of the user, in comparison to when the base liquid and the pill, caplet, capsule or tablet are administered together and swallowed, and administering the pill, caplet, capsule or tablet and the oral delivery composition together to a user.
14. A method for swallowing of a pill, caplet, capsule or tablet by a user, the method comprising the steps of:
providing an oral delivery composition comprising a mixture of a base liquid and an additive or additives, wherein the additive or additives, alone or in combination, have the properties of a thickening agent, a surfactant and a lubricating agent and are selected and present in the oral delivery composition in a sufficient concentration such that the oral delivery composition has the following properties:
(1) a density that is greater than the density of the base liquid, (2) a surface tension that is less than the surface tension of the base liquid, (3) a viscosity that is greater than the viscosity of the base liquid, and is in the range of between 10 and 20 centipoise at 36.5 °C, (4) a wettability that is greater that the wettability of the base liquid, (5) a lubricity that is greater than the lubricity of the base liquid, and (6) a lower interfacial tension than the interfacial tension of the base liquid, such that when the oral delivery composition and the pill, caplet, capsule or tablet are administered together to a user and swallowed, the pill, caplet, capsule or tablet becomes wetted and engulfed by the liquid so that it is less likely to become lodged or stuck on tongue, throat, palate or esophageal surfaces of the user, in comparison to when the base liquid and the pill, caplet, tablet, or capsule are administered together and swallowed, and administering the pill, caplet, capsule or tablet and the oral delivery composition together to the user.
providing an oral delivery composition comprising a mixture of a base liquid and an additive or additives, wherein the additive or additives, alone or in combination, have the properties of a thickening agent, a surfactant and a lubricating agent and are selected and present in the oral delivery composition in a sufficient concentration such that the oral delivery composition has the following properties:
(1) a density that is greater than the density of the base liquid, (2) a surface tension that is less than the surface tension of the base liquid, (3) a viscosity that is greater than the viscosity of the base liquid, and is in the range of between 10 and 20 centipoise at 36.5 °C, (4) a wettability that is greater that the wettability of the base liquid, (5) a lubricity that is greater than the lubricity of the base liquid, and (6) a lower interfacial tension than the interfacial tension of the base liquid, such that when the oral delivery composition and the pill, caplet, capsule or tablet are administered together to a user and swallowed, the pill, caplet, capsule or tablet becomes wetted and engulfed by the liquid so that it is less likely to become lodged or stuck on tongue, throat, palate or esophageal surfaces of the user, in comparison to when the base liquid and the pill, caplet, tablet, or capsule are administered together and swallowed, and administering the pill, caplet, capsule or tablet and the oral delivery composition together to the user.
15. The method of Claim 14 wherein the base liquid comprises water.
16. The method of Claim 14 wherein the base liquid comprises a fruit juice.
17. The method of Claim l4wherein the additive or additives comprise a polysaccharide and a polysorbate surfactant.
18. The method of Claim 17 wherein the polysaccharide is selected from the group consisting of guar, locust bean, tamarind, arabic, karaya, tragacanth, agar, algin, carrageenan, xanthan, celluloses, pectins, carboxylated algin, carboxymethyl cellulose, hydroxypropyl methyl cellulose, carboxylated pectin, carboxylated xanthan, sulfated carrageenen, sulfated furcellaran and gellan.
19. The method of Claim 14 wherein the additive or additives comprise a water soluble cellulosic polymer and a polyoxyethylene sorbitan fatty acid ester.
20. The method of Claim 14 wherein the additive or additives comprise carboxyl methyl cellulose and polyoxyethylene sorbitan monooleate.
21. The method of Claim 14 wherein the oral delivery composition further contains at least one of sweeteners and flavors.
22. The method of Claim 14 wherein the pill, capsule, caplet or tablet is elongated in one dimension and wherein, when the elongated pill, capsule, caplet or tablet is administered to a user together with the oral delivery composition, the oral delivery composition exerts a force on the elongated pill, capsule, caplet or tablet to cause the elongated pill, capsule or tablet to line up axially with the throat passage of the user.
23. The method of Claim 14 wherein the pill, capsule, caplet or tablet comprises a material that has a tendency to crumble or dissolve when exposed to water or natural fluids in the mouth of the user, and wherein, when the pill, capsule or tablet is administered to a user together with the oral delivery composition, the oral delivery composition facilitates the swallowing of the pill, capsule, caplet or tablet before crumbling or dissolving of the pill, capsule, caplet or tablet can occur in the mouth of the user.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19459200P | 2000-04-05 | 2000-04-05 | |
| US60/194,592 | 2000-04-05 | ||
| US09/672,949 | 2000-09-29 | ||
| US09/672,949 US6337083B1 (en) | 2000-04-05 | 2000-09-29 | Oral delivery method and composition for solid medications or dietary supplements |
| PCT/US2001/010989 WO2001076634A1 (en) | 2000-04-05 | 2001-04-05 | Oral delivery method and composition for solid medications or dietary supplements |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2404641A1 true CA2404641A1 (en) | 2001-10-18 |
| CA2404641C CA2404641C (en) | 2010-10-26 |
Family
ID=26890190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2404641A Expired - Fee Related CA2404641C (en) | 2000-04-05 | 2001-04-05 | Oral delivery method and composition for solid medications or dietary supplements |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6337083B1 (en) |
| EP (1) | EP1385552B1 (en) |
| JP (1) | JP2003530359A (en) |
| CN (1) | CN1431916A (en) |
| AT (1) | ATE364401T1 (en) |
| AU (2) | AU2001249860B2 (en) |
| BR (1) | BR0109917A (en) |
| CA (1) | CA2404641C (en) |
| DE (1) | DE60128966T2 (en) |
| MX (1) | MXPA02009945A (en) |
| WO (1) | WO2001076634A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE39125E1 (en) | 2000-03-13 | 2006-06-13 | Ryukakusan Co. Ltd | Swallowing-assistive drink |
| EP1618149B1 (en) * | 2003-04-25 | 2007-01-17 | Reckitt Benckiser Healthcare (UK) Limited | Thickenable compositions |
| US20050208108A1 (en) * | 2004-03-19 | 2005-09-22 | Jannusch Leonard C | Thermoplastic films and methods for making |
| GB2430364A (en) * | 2005-09-22 | 2007-03-28 | Carl Ernest Alexander | Soft agar bolus for oral drug delivery |
| US8187659B2 (en) * | 2006-05-02 | 2012-05-29 | Jerry Robertson Real Estate Llc | Solid medicament dosage form consumption aid |
| US8383135B2 (en) | 2010-12-03 | 2013-02-26 | Richard C. Fuisz | Solid dosage form that promotes reliable oral, esophageal and GI transit |
| US9452135B2 (en) | 2012-03-20 | 2016-09-27 | Particle Dynamics International, Llc | Gelling agent-based dosage form |
| FR3001153B1 (en) | 2013-01-21 | 2015-08-21 | Eredova | ASSISTING PRODUCT FOR THE INGESTION OF A SOLID COMPOUND |
| US11234897B2 (en) | 2017-03-27 | 2022-02-01 | DXM Pharmaceutical, Inc. | Packaged multi-dose liquid dextromethorphan hydrobromide formulation |
| IT201800001301A1 (en) * | 2018-01-18 | 2019-07-18 | Univ Degli Studi Di Camerino | Gel formulations for oral administration of drugs, particularly in dysphagia patients |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0610341B1 (en) * | 1991-10-28 | 1996-09-18 | The Procter & Gamble Company | Beverage thickener/emulsifier system |
| JPH05139958A (en) * | 1991-11-26 | 1993-06-08 | Freunt Ind Co Ltd | Easily swallowable agent |
| US5472711A (en) * | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
| JPH0826976A (en) * | 1994-07-21 | 1996-01-30 | Freunt Ind Co Ltd | Food-like medicine |
| JP4309481B2 (en) * | 1996-01-12 | 2009-08-05 | テイコクメディックス株式会社 | Jelly oral pharmaceutical composition |
| US5643204A (en) * | 1996-03-15 | 1997-07-01 | Cover; Charles L. | Pill swallowing device and method |
| US6709678B2 (en) * | 1996-08-15 | 2004-03-23 | Losan Pharma Gmbh | Easy to swallow oral medicament composition |
| US6143276A (en) * | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
| JP3257983B2 (en) * | 1997-07-31 | 2002-02-18 | 株式会社龍角散 | Drug swallowing aid drink |
| JP3798913B2 (en) * | 1998-07-31 | 2006-07-19 | 伊那食品工業株式会社 | Additive for thickening |
| JP4248653B2 (en) * | 1998-12-28 | 2009-04-02 | ライオン株式会社 | Easily swallowing assist composition, food composition and pharmaceutical composition using the same |
| WO2000044242A1 (en) * | 1999-01-28 | 2000-08-03 | Dainippon Pharmaceutical Co., Ltd. | Intake/swallowing-assistant foods and process for producing the same |
-
2000
- 2000-09-29 US US09/672,949 patent/US6337083B1/en not_active Expired - Lifetime
-
2001
- 2001-04-05 EP EP01923138A patent/EP1385552B1/en not_active Expired - Lifetime
- 2001-04-05 AT AT01923138T patent/ATE364401T1/en not_active IP Right Cessation
- 2001-04-05 AU AU2001249860A patent/AU2001249860B2/en not_active Ceased
- 2001-04-05 JP JP2001574149A patent/JP2003530359A/en active Pending
- 2001-04-05 AU AU4986001A patent/AU4986001A/en active Pending
- 2001-04-05 BR BR0109917-5A patent/BR0109917A/en not_active Application Discontinuation
- 2001-04-05 DE DE60128966T patent/DE60128966T2/en not_active Expired - Lifetime
- 2001-04-05 WO PCT/US2001/010989 patent/WO2001076634A1/en active IP Right Grant
- 2001-04-05 MX MXPA02009945A patent/MXPA02009945A/en active IP Right Grant
- 2001-04-05 CN CN01810540A patent/CN1431916A/en active Pending
- 2001-04-05 CA CA2404641A patent/CA2404641C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003530359A (en) | 2003-10-14 |
| ATE364401T1 (en) | 2007-07-15 |
| AU2001249860B2 (en) | 2005-12-01 |
| EP1385552A4 (en) | 2005-08-10 |
| AU4986001A (en) | 2001-10-23 |
| EP1385552A1 (en) | 2004-02-04 |
| CN1431916A (en) | 2003-07-23 |
| MXPA02009945A (en) | 2004-08-19 |
| BR0109917A (en) | 2003-08-05 |
| WO2001076634A1 (en) | 2001-10-18 |
| DE60128966T2 (en) | 2008-02-28 |
| DE60128966D1 (en) | 2007-07-26 |
| US6337083B1 (en) | 2002-01-08 |
| CA2404641C (en) | 2010-10-26 |
| EP1385552B1 (en) | 2007-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20140407 |