CA2399047C - Reactifs et methodes de detection des pathologies mammaires - Google Patents

Reactifs et methodes de detection des pathologies mammaires Download PDF

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Publication number
CA2399047C
CA2399047C CA2399047A CA2399047A CA2399047C CA 2399047 C CA2399047 C CA 2399047C CA 2399047 A CA2399047 A CA 2399047A CA 2399047 A CA2399047 A CA 2399047A CA 2399047 C CA2399047 C CA 2399047C
Authority
CA
Canada
Prior art keywords
sequence
polypeptide
antibody
breast
mpa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2399047A
Other languages
English (en)
Other versions
CA2399047A1 (fr
Inventor
Patricia A. Billing-Medel
Maurice Cohen
Tracey L. Colpitts
Paula N. Friedman
Julian Gordon
Edward N. Granados
Steven C. Hodges
Michael R. Klass
Jon D. Kratochvil
Lisa Roberts-Rapp
John C. Russell
Steven D. Stroupe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of CA2399047A1 publication Critical patent/CA2399047A1/fr
Application granted granted Critical
Publication of CA2399047C publication Critical patent/CA2399047C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention porte sur un ensemble de séquences d'ARN contiguës et se recouvrant partiellement et sur les polypeptides codés par elles. Lesdites séquences, dites BS106, transcrites à partir de tissus mammaires, peuvent servir à la détection, au diagnostic, à la stadification, au suivi, aux pronostics, à la prévention, et au traitement des maladies et pathologies du sein tels que le cancer, et à déterminer la prédisposition d'un individu à ces maladies et pathologies. L'invention porte également sur des anticorps se fixant spécifiquement aux polypeptide ou protéines codés par les BS106 et sur des agonistes ou inhibiteurs empêchant l'action des polypeptide BS106 spécifiques d'un tissu, ces molécules étant utiles pour le traitement des maladies, tumeurs, et métastases du sein.
CA2399047A 2000-02-29 2001-02-28 Reactifs et methodes de detection des pathologies mammaires Expired - Fee Related CA2399047C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51644400A 2000-02-29 2000-02-29
US09/516,444 2000-02-29
PCT/US2001/006516 WO2001065262A2 (fr) 2000-02-29 2001-02-28 Reactifs et methodes de detection des pathologies mammaires

Publications (2)

Publication Number Publication Date
CA2399047A1 CA2399047A1 (fr) 2001-09-07
CA2399047C true CA2399047C (fr) 2011-04-19

Family

ID=24055614

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2399047A Expired - Fee Related CA2399047C (fr) 2000-02-29 2001-02-28 Reactifs et methodes de detection des pathologies mammaires

Country Status (4)

Country Link
EP (1) EP1259542A2 (fr)
JP (1) JP2004503208A (fr)
CA (1) CA2399047C (fr)
WO (1) WO2001065262A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8034920B2 (en) 1997-10-31 2011-10-11 Abbott Laboratories Nucleic acid primers and probes for detecting breast cells
WO2001035811A2 (fr) * 1999-11-16 2001-05-25 Eos Biotechnology, Inc. Nouvelles methodes diagnostiques et pronostiques du cancer du sein, compositions et procedes de criblage de modulateurs de cancer du sein
EP1805325A1 (fr) * 2004-10-28 2007-07-11 Abbott Laboratories Amorces d'acide nucleique et sondes pour detecter des cellules mammaires
US8980269B2 (en) 2009-07-14 2015-03-17 Temple University Of The Commonwealth System Of Higher Education G-protein coupled receptor-associated sorting protein 1 as a cancer biomarker
EP2727935A3 (fr) * 2009-07-14 2014-07-30 Temple University Of The Commonwealth System Of Higher Education Marqueurs sériques associés à des stades précoces et autres du cancer du sein

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018945A1 (fr) * 1996-10-31 1998-05-07 Abbott Laboratories Reactifs et procedes pour le depistage de pathologies mammaires
CA2270156A1 (fr) * 1996-11-12 1998-05-22 Incyte Pharmaceuticals, Inc. Proteines humaines specifiques de tumeur du sein
JP2001521744A (ja) * 1997-10-31 2001-11-13 アボット・ラボラトリーズ 乳房の疾患の検出に有用な試薬および方法

Also Published As

Publication number Publication date
CA2399047A1 (fr) 2001-09-07
WO2001065262A3 (fr) 2002-04-11
WO2001065262A2 (fr) 2001-09-07
EP1259542A2 (fr) 2002-11-27
JP2004503208A (ja) 2004-02-05

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Effective date: 20150302