CA2396883C - Diagnostic non invasif de maladies de la peau par spectroscopie dans le visible/l'infrarouge proche - Google Patents

Diagnostic non invasif de maladies de la peau par spectroscopie dans le visible/l'infrarouge proche Download PDF

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Publication number
CA2396883C
CA2396883C CA2396883A CA2396883A CA2396883C CA 2396883 C CA2396883 C CA 2396883C CA 2396883 A CA2396883 A CA 2396883A CA 2396883 A CA2396883 A CA 2396883A CA 2396883 C CA2396883 C CA 2396883C
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CA
Canada
Prior art keywords
skin
spectrum
spectra
nevi
visible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2396883A
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English (en)
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CA2396883A1 (fr
Inventor
Laura M. Mcintosh
Michael Jackson
Henry H. Mantsch
James R. Mansfield
A. Neil Crowson
John W. P. Toole
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National Research Council of Canada
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National Research Council of Canada
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Publication of CA2396883A1 publication Critical patent/CA2396883A1/fr
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Publication of CA2396883C publication Critical patent/CA2396883C/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/444—Evaluating skin marks, e.g. mole, nevi, tumour, scar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/445—Evaluating skin irritation or skin trauma, e.g. rash, eczema, wound, bed sore
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne un outil non invasif pour effectuer le diagnostic de maladies de la peau, destiné à être utilisé en tant que dispositif clinique auxiliaire. L'étude sur laquelle est fondée cette invention avait pour but de déterminer si la spectroscopie dans le visible/infrarouge proche peut être exploité pour la caractérisation non invasive de maladies de la peau. Des spectres in vivo dans le visible et infrarouge proche (400-2500 nm) de tumeurs de la peau (kératoses séniles, carcinomes basocellulaires, naevus mélanocytaires banals communs acquis, naevus mélanocytaires dysplastiques, lentigines actiniques et kératoses séborrhéiques) ont été obtenus au moyen d'une sonde à fibre optique placée sur la peau. On a fait appel à des tests t jumelés, à une analyse de variance et à une analyse discriminatoire de mesures répétées pour déterminer s'il y avait des différences spectrales significatives et si les spectres pouvaient être classés selon le type de lésion. Les tests t jumelés ont montré des différences significatives (p<0,05) entre une peau normale et une peau présentant des lésions, dans plusieurs zones du spectre visible/infrarouge proche. En outre, des différences significatives ont été trouvées entre les groupes de lésions, par analyse de variance. L'analyse discriminatoire linéaire a permis de différencier des spectres résultant de lésions bénignes, en comparaison avec des lésions pré-malignes ou malignes. La spectroscopie dans le visible/infrarouge rouge constitue une technique non invasive prometteuse pour le diagnostic de maladies de la peau.
CA2396883A 1999-10-06 2000-10-05 Diagnostic non invasif de maladies de la peau par spectroscopie dans le visible/l'infrarouge proche Expired - Lifetime CA2396883C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15785799P 1999-10-06 1999-10-06
US60/157,857 1999-10-06
PCT/CA2000/001187 WO2001024699A2 (fr) 1999-10-06 2000-10-05 Diagnostic non invasif de maladies de la peau par spectroscopie dans le visible/l'infrarouge proche

Publications (2)

Publication Number Publication Date
CA2396883A1 CA2396883A1 (fr) 2001-04-12
CA2396883C true CA2396883C (fr) 2011-04-12

Family

ID=22565569

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2396883A Expired - Lifetime CA2396883C (fr) 1999-10-06 2000-10-05 Diagnostic non invasif de maladies de la peau par spectroscopie dans le visible/l'infrarouge proche

Country Status (4)

Country Link
EP (1) EP1237479A2 (fr)
AU (1) AU782431B2 (fr)
CA (1) CA2396883C (fr)
WO (1) WO2001024699A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10346757A1 (de) * 2003-10-06 2005-05-12 Pe Diagnostik Gmbh Verfahren zur Klassifikation von Messwerten in der medizinischen und biochemischen Analytik
WO2010085954A1 (fr) * 2009-01-29 2010-08-05 Leo Pharma A/S Procédé de détermination de l'état d'un trouble cutané au moyen de la spectroscopie infrarouge proche
EP2490586B1 (fr) 2009-10-23 2014-11-12 Medespel Ltd Système d'examen de tissu non invasif
CA2986295C (fr) 2015-07-10 2023-01-03 Infectopharm Arzneimittel Und Consilium Gmbh Utilisation d'hydroxyde de potassium dans le traitement de la keratose actinique
WO2020086552A1 (fr) * 2018-10-23 2020-04-30 Aesthetics Biomedical, Inc. Procédés, dispositifs et systèmes pour induire une régénération de collagène

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5016173A (en) * 1989-04-13 1991-05-14 Vanguard Imaging Ltd. Apparatus and method for monitoring visually accessible surfaces of the body
US6008889A (en) * 1997-04-16 1999-12-28 Zeng; Haishan Spectrometer system for diagnosis of skin disease

Also Published As

Publication number Publication date
CA2396883A1 (fr) 2001-04-12
AU782431B2 (en) 2005-07-28
AU7766200A (en) 2001-05-10
WO2001024699A2 (fr) 2001-04-12
WO2001024699A8 (fr) 2001-10-04
EP1237479A2 (fr) 2002-09-11

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