CA2391451A1 - Referencing and rapid sampling in artificial olfactometry - Google Patents
Referencing and rapid sampling in artificial olfactometry Download PDFInfo
- Publication number
- CA2391451A1 CA2391451A1 CA002391451A CA2391451A CA2391451A1 CA 2391451 A1 CA2391451 A1 CA 2391451A1 CA 002391451 A CA002391451 A CA 002391451A CA 2391451 A CA2391451 A CA 2391451A CA 2391451 A1 CA2391451 A1 CA 2391451A1
- Authority
- CA
- Canada
- Prior art keywords
- sensor
- sensors
- analyte
- array
- sensing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000005070 sampling Methods 0.000 title 1
- 239000012491 analyte Substances 0.000 claims abstract 15
- 238000000034 method Methods 0.000 claims abstract 14
- 238000003491 array Methods 0.000 claims abstract 5
- 238000001514 detection method Methods 0.000 claims abstract 4
- 238000013507 mapping Methods 0.000 claims abstract 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 10
- 235000012239 silicon dioxide Nutrition 0.000 claims 7
- 229910044991 metal oxide Inorganic materials 0.000 claims 5
- 150000004706 metal oxides Chemical class 0.000 claims 5
- 239000010453 quartz Substances 0.000 claims 4
- 229910052681 coesite Inorganic materials 0.000 claims 3
- 239000002322 conducting polymer Substances 0.000 claims 3
- 229920001940 conductive polymer Polymers 0.000 claims 3
- 229910052906 cristobalite Inorganic materials 0.000 claims 3
- 230000003287 optical effect Effects 0.000 claims 3
- 230000008786 sensory perception of smell Effects 0.000 claims 3
- 239000000377 silicon dioxide Substances 0.000 claims 3
- 229910052682 stishovite Inorganic materials 0.000 claims 3
- 229910052905 tridymite Inorganic materials 0.000 claims 3
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- 230000003197 catalytic effect Effects 0.000 claims 2
- 239000002131 composite material Substances 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- 239000000835 fiber Substances 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 239000007784 solid electrolyte Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- BOTDANWDWHJENH-UHFFFAOYSA-N Tetraethyl orthosilicate Chemical compound CCO[Si](OCC)(OCC)OCC BOTDANWDWHJENH-UHFFFAOYSA-N 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 238000009792 diffusion process Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940000406 drug candidate Drugs 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 230000013011 mating Effects 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 238000012806 monitoring device Methods 0.000 claims 1
- 238000007899 nucleic acid hybridization Methods 0.000 claims 1
- 238000003909 pattern recognition Methods 0.000 claims 1
- 238000000513 principal component analysis Methods 0.000 claims 1
- 239000004065 semiconductor Substances 0.000 claims 1
- 229910000077 silane Inorganic materials 0.000 claims 1
- 239000005368 silicate glass Substances 0.000 claims 1
- 238000010897 surface acoustic wave method Methods 0.000 claims 1
- -1 testraethoxysilane Chemical compound 0.000 claims 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0006—Calibrating gas analysers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
- G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
- G01N33/0031—General constructional details of gas analysers, e.g. portable test equipment concerning the detector comprising two or more sensors, e.g. a sensor array
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Combustion & Propulsion (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
Abstract
Devices and methods are disclosed that are effective to produce reliable vapor measurements in the presence of drift.
In certain instances the sensor module (14) is mounted externally on a housing. In other instances, the sensor module (14) contains a first sensor element incorporating a first array of sensors and a second element incorporating a second array of sensors and both sensor elements are mounted externally on the housing. The present invention relates to mapping an x-y surface for detection of an analyte, includes moving in tandem at least two sensor arrays separated by a distance "d" across an x-y surface to produce a plurality of responses and analyzing the responses to map the x-y surface for detection of an analyte. Moreover, a sensor module (14) is provided, such as in a handheld device (10), comprising at least two pneumatic vapor paths and at least two sensor arrays. The dual pneumatic train allows rapid sensing as it increases the duty cycle frequency.
In certain instances the sensor module (14) is mounted externally on a housing. In other instances, the sensor module (14) contains a first sensor element incorporating a first array of sensors and a second element incorporating a second array of sensors and both sensor elements are mounted externally on the housing. The present invention relates to mapping an x-y surface for detection of an analyte, includes moving in tandem at least two sensor arrays separated by a distance "d" across an x-y surface to produce a plurality of responses and analyzing the responses to map the x-y surface for detection of an analyte. Moreover, a sensor module (14) is provided, such as in a handheld device (10), comprising at least two pneumatic vapor paths and at least two sensor arrays. The dual pneumatic train allows rapid sensing as it increases the duty cycle frequency.
Claims (35)
1. A method for reducing drift in an artificial olfaction device having an array of sensors, said method comprising:
contacting said array of sensor with an analyte at a first temperature to produce a first response;
contacting said array of sensor with said analyte at a second temperature to produce a second response; and subtracting the first response from the second response thereby reducing drift in said sensor array.
contacting said array of sensor with an analyte at a first temperature to produce a first response;
contacting said array of sensor with said analyte at a second temperature to produce a second response; and subtracting the first response from the second response thereby reducing drift in said sensor array.
2. The method of claim 1, wherein at least one sensor in said array of sensors in selected from the group consisting of a conducting and nonconducting regions sensor, a SAW sensor, a quartz microbalance sensor, a conductive composite sensor, a chemiresitor, a metal oxide gas sensor, an organic gas sensor, a MOSFET, a piezoelectric device, an infrared sensor, a sintered metal oxide sensor, a Pd-gate MOSFET, a metal FET structure, a electrochemical cell, a conducting polymer sensor, a catalytic gas sensor, an organic semiconducting gas sensor, a fiber optical chemical sensor, a solid electrolyte gas sensors, and a piezoelectric quartz crystal sensor.
3. The method of claim 2, wherein at least one sensor is a conducting and nonconducting regions sensor.
4. The method of claim 2, wherein at least one sensor is a SAW
sensor.
sensor.
5. The method of claim 1, wherein said analyte and said sensor array are equilibrated at said first temperature.
6. The method of claim 1, wherein said analyte and said sensor array are equilibrated at said second temperature.
7. The method of claim 1, wherein the difference between said first temperature and said second temperature is between about 5°C and about 150°C.
8. The method of claim 7, wherein the difference between said first temperature and said second temperature is between about 2°C to about 70°C.
9. The method of claim 1, wherein said artificial olfaction device comprises two arrays of sensors.
10. The method of claim 1, wherein said artificial olfaction device is a handheld device.
11. A sensor module configured for external mounting on a sensing apparatus for detecting an analyte in a fluid, said sensor module comprising:
a casing sized and configured to be received in a receptacle of the sensing apparatus;
at least two sensor to provide a distinct response when exposed to one or more analytes; and an electrical connector configured to be releasably engageable with a mating electrical connector of the sensing apparatus when the sensor module is received in the receptacle, said electrical connector transmitting the characteristic signals from the at least two sensors to the sensing apparatus.
a casing sized and configured to be received in a receptacle of the sensing apparatus;
at least two sensor to provide a distinct response when exposed to one or more analytes; and an electrical connector configured to be releasably engageable with a mating electrical connector of the sensing apparatus when the sensor module is received in the receptacle, said electrical connector transmitting the characteristic signals from the at least two sensors to the sensing apparatus.
12. The sensor module of claim 11, wherein said sensor module comprises a memory device.
13. The sensor module of claim 11, wherein at least one sensor in said array of sensors in selected from the group consisting of a conducting and nonconducting regions sensor, a SAW sensor, a quartz microbalance sensor, a conductive composite sensor, a chemiresitor, a metal oxide gas sensor, an organic gas sensor, a MOSFET, a piezoelectric device, an infrared sensor, a sintered metal oxide sensor, a Pd-gate MOSFET, a metal FET structure, a electrochemical cell, a conducting polymer sensor, a catalytic gas sensor, an organic semiconducting gas sensor, fiber optical chemical sensor, a solid electrolyte gas sensors, and a piezoelectric quartz crystal sensor.
14. The sensor module of claim 13, wherein at least one sensor is a conducting and nonconducting regions sensor.
15. The sensor module of claim 13, wherein at least one sensor is a SAW sensor.
16. The sensor module of claim 11, wherein said sensing apparatus is a handheld device.
17. A sensing device for detecting an analyte, said device comprising:
a housing;
a sensor module mounted externally on said housing and incorporating an array of sensors, each of said sensors providing a different response in the presence of said analyte;
a monitoring device mounted on said housing and configured to monitor said responses of the array of sensors incorporated in the sensor module, and further configured to produce a plurality of sensor signals; and an analyzer mounted on said housing and configured to analyze said plurality of sensor signals to identify said analyte.
a housing;
a sensor module mounted externally on said housing and incorporating an array of sensors, each of said sensors providing a different response in the presence of said analyte;
a monitoring device mounted on said housing and configured to monitor said responses of the array of sensors incorporated in the sensor module, and further configured to produce a plurality of sensor signals; and an analyzer mounted on said housing and configured to analyze said plurality of sensor signals to identify said analyte.
18. The sensor device according to claim 17, wherein said sensor module is capable of automatic physical movement.
19. The sensor device according to claim 17, wherein said sensor module comprises at least two pneumatic vapor paths and at least two sensor arrays.
20. The sensor device according to claim 17, wherein said response is a member selected from the groups consisting of resistance, impedance, mechanical capacitance, inductance, frequency, magnetic and optical.
21. The sensor device according to claim 17, wherein at least one sensor is selected from the group consisting of inorganic metal oxide semiconductors, intrinsically conducting polymers, mass sensitive piezoelectric sensors, surface acoustic wave sensors and nonconducting and conducting regions sensors.
22. The sensor device according to claim 17, wherein said analyzer comprises a comparison algorithm wherein said comparison is performed using a pattern recognition algorithm which is a member selected from the group consisting of principal component analysis, Fisher linear discriminant analysis, soft independent modeling of class analogy, K-nearest neighbors, and canonical discriminant analysis.
23. A sensing device for detecting an analyte in a fluid, said device comprising:
a first sensor element having a first sensor array for producing a response in the presence of said analyte;
a second sensing element having a second sensor array for referencing said system;
a computer coupled to said first and said second sensing elements having a resident algorithm.
a first sensor element having a first sensor array for producing a response in the presence of said analyte;
a second sensing element having a second sensor array for referencing said system;
a computer coupled to said first and said second sensing elements having a resident algorithm.
24. The sensing device according to claim 23, wherein said first sensing element is physically located distinctly from said second sensing element.
25. The sensing device according to claim 24, wherein said second sensing element has attached thereto a pasivation layer.
26. The sensing device according to claim 25, wherein said pasivation layer comprises a material that is a member selected from the group consisting of SiO2 and SiO2 based films.
27. The sensing device according to claim 26, wherein said SiO2 based film is a member selected from the group consisting of thermal oxides, silane, SiH4, testraethoxysilane, Si(OC2H5)4, silicate glasses, and spin on glass.
28. The sensing device according to claim 24, wherein said first sensing element is in a first sample chamber and said second sensing element is in a second sample chamber.
29. The sensing device according to claim 24, wherein said second sensing element has attached thereto a porous membrane layer.
30. The sensing device according to claim 29, wherein said porous membrane layer limits diffusion of said analyte.
31. The sensing device according to claim 24, wherein said second sensing element is a reference element and sensing element is temperature controlled.
32. A method for mapping an x-y surface for detection of an analyte, said method comprising:
moving in tandem at least two sensor arrays separated by a distance "d"
across an x-y surface to produce a plurality of responses; and analyzing said responses and thereby mapping the x-y surface for detection of said analyte.
moving in tandem at least two sensor arrays separated by a distance "d"
across an x-y surface to produce a plurality of responses; and analyzing said responses and thereby mapping the x-y surface for detection of said analyte.
33. A parallel independent sensor array device for detecting a plurality of test samples independently and simultaneously, said parallel independent sensor array device comprising:
a parallel matrix of sensors to produce a plurality of responses each of said plurality of responses generated from a corresponding plurality of test samples; and an electrical measuring apparatus to simultaneously detect each of said plurality of responses.
a parallel matrix of sensors to produce a plurality of responses each of said plurality of responses generated from a corresponding plurality of test samples; and an electrical measuring apparatus to simultaneously detect each of said plurality of responses.
34. The device of claim 33, further comprising a computer coupled to each of said sensors having a resident algorithm.
35. The device of claim 33, wherein each of said plurality of responses is generated from a member selected from the group consisting of antibiotics, catalysts, drugs, biomolecule binding efficiencies, nucleic acid hybridizations, ligand-ligand interactions, biomolecule interactions, and drug candidates.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16543799P | 1999-11-15 | 1999-11-15 | |
| US60/165,437 | 1999-11-15 | ||
| PCT/US2000/031515 WO2001036961A1 (en) | 1999-11-15 | 2000-11-14 | Referencing and rapid sampling in artificial olfactometry |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2391451A1 true CA2391451A1 (en) | 2001-05-25 |
| CA2391451C CA2391451C (en) | 2010-04-13 |
Family
ID=22598891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2391451A Expired - Fee Related CA2391451C (en) | 1999-11-15 | 2000-11-14 | Referencing and rapid sampling in artificial olfactometry |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1255988A4 (en) |
| AU (1) | AU781321B2 (en) |
| CA (1) | CA2391451C (en) |
| WO (1) | WO2001036961A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10329834A1 (en) * | 2003-07-02 | 2005-02-03 | Dräger Safety AG & Co. KGaA | Modular gas measuring system |
| US7228725B2 (en) | 2004-01-27 | 2007-06-12 | H2Scan Llc | Thin film gas sensor configuration |
| CN102890718B (en) * | 2012-10-10 | 2015-04-08 | 重庆大学 | Electronic nose data mining method based on supervised explicit manifold learning algorithm |
| EP3879266A1 (en) | 2020-03-11 | 2021-09-15 | Infineon Technologies AG | Gas sensing device and method for operating a gas sensing device |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5571401A (en) * | 1995-03-27 | 1996-11-05 | California Institute Of Technology | Sensor arrays for detecting analytes in fluids |
| US6060327A (en) * | 1997-05-14 | 2000-05-09 | Keensense, Inc. | Molecular wire injection sensors |
| EP1064530B1 (en) * | 1998-03-20 | 2015-10-28 | Smiths Detection Inc. | Handheld sensing apparatus |
| US6085576A (en) * | 1998-03-20 | 2000-07-11 | Cyrano Sciences, Inc. | Handheld sensing apparatus |
-
2000
- 2000-11-14 WO PCT/US2000/031515 patent/WO2001036961A1/en active IP Right Grant
- 2000-11-14 AU AU19209/01A patent/AU781321B2/en not_active Ceased
- 2000-11-14 CA CA2391451A patent/CA2391451C/en not_active Expired - Fee Related
- 2000-11-14 EP EP00982140A patent/EP1255988A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU781321B2 (en) | 2005-05-19 |
| WO2001036961A1 (en) | 2001-05-25 |
| EP1255988A4 (en) | 2005-12-28 |
| AU1920901A (en) | 2001-05-30 |
| EP1255988A1 (en) | 2002-11-13 |
| CA2391451C (en) | 2010-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |