CA2388868A1 - Methode de stimulation de l'angiogenese regulee par peptides pr-39 - Google Patents

Methode de stimulation de l'angiogenese regulee par peptides pr-39 Download PDF

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Publication number
CA2388868A1
CA2388868A1 CA002388868A CA2388868A CA2388868A1 CA 2388868 A1 CA2388868 A1 CA 2388868A1 CA 002388868 A CA002388868 A CA 002388868A CA 2388868 A CA2388868 A CA 2388868A CA 2388868 A1 CA2388868 A1 CA 2388868A1
Authority
CA
Canada
Prior art keywords
cells
pro
arg
peptide
proteasomes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002388868A
Other languages
English (en)
Inventor
Michael Simons
Youhe Gao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beth Israel Deaconess Medical Center Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/426,011 external-priority patent/US7345021B1/en
Application filed by Individual filed Critical Individual
Publication of CA2388868A1 publication Critical patent/CA2388868A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne à la fois une méthode et un moyen de régulation de l'angiogenèse dans des cellules vivantes, de tissus, ainsi que des organes in situ. La régulation s'effectue au moyen d'un peptide PR-39 natif ou d'un de ses homologues de longueur plus courte, afin d'avoir une interaction avec des protéasomes tels que ceux présents dans le cytoplasme de cellules viables. Le résultat de l'interaction du peptide PR-39 avec les protéasomes est une diminution de la dégradation intracellulaire de peptides actifs tels que HIF-1.alpha.; et par conséquent une stimulation de l'angiogénèse in situ.
CA002388868A 1999-10-25 2000-10-06 Methode de stimulation de l'angiogenese regulee par peptides pr-39 Abandoned CA2388868A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/426,011 1999-10-25
US09/426,011 US7345021B1 (en) 1999-03-26 1999-10-25 Method for PR-39 peptide regulated stimulation of angiogenesis
PCT/US2000/027552 WO2001030368A1 (fr) 1999-10-25 2000-10-06 Methode de stimulation de l'angiogenese regulee par peptides pr-39

Publications (1)

Publication Number Publication Date
CA2388868A1 true CA2388868A1 (fr) 2001-05-03

Family

ID=23688917

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002388868A Abandoned CA2388868A1 (fr) 1999-10-25 2000-10-06 Methode de stimulation de l'angiogenese regulee par peptides pr-39

Country Status (3)

Country Link
AU (1) AU7995400A (fr)
CA (1) CA2388868A1 (fr)
WO (1) WO2001030368A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001047540A1 (fr) * 1999-12-29 2001-07-05 Beth Israel Deaconess Medical Center PROCEDE D'INHIBITION SELECTIVE DE LA DEGRADATION DE LA PROTEINE IλBα INDUITE PAR LE PEPTIDE PR-39
EP1802655B1 (fr) 2004-10-18 2013-07-24 BASF Beauty Care Solutions S.A.S. Oligopeptides et leur utilisation en cosmetique
ES2686777T3 (es) * 2004-11-24 2018-10-19 Lifescan, Inc. Composiciones y métodos para crear un ambiente vascularizado para trasplante celular
AU2017230737B2 (en) * 2016-03-09 2022-07-14 Incube Labs, Llc Methods and articles for delivering viable cells into solid tissue

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654273A (en) * 1994-09-22 1997-08-05 Children's Medical Center Corporation Synducin mediated modulation of tissue repair

Also Published As

Publication number Publication date
AU7995400A (en) 2001-05-08
WO2001030368A1 (fr) 2001-05-03

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued