CA2381252A1 - Composes d'ether 3-pyrrolidinyloxy-3'-pyridyle utilises comme regulateurs de la transmission synaptique chimique - Google Patents
Composes d'ether 3-pyrrolidinyloxy-3'-pyridyle utilises comme regulateurs de la transmission synaptique chimique Download PDFInfo
- Publication number
- CA2381252A1 CA2381252A1 CA002381252A CA2381252A CA2381252A1 CA 2381252 A1 CA2381252 A1 CA 2381252A1 CA 002381252 A CA002381252 A CA 002381252A CA 2381252 A CA2381252 A CA 2381252A CA 2381252 A1 CA2381252 A1 CA 2381252A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- pyrrolidinyloxy
- pyridine
- methyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
L'invention concerne une série de composés d'éther 3-pyrrolidinyloxy-3'-pyridyle, un procédé permettant de réguler sélectivement la sécrétion des neurotransmetteurs chez des mammifères au moyen de ces composés, et des compositions pharmaceutiques contenant ces composés. Les composés préférés sont des pyridyléthers 3-pyrrolidinylméthoxy-3'-(5'-et/ou 6'-substitué).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39514699A | 1999-09-14 | 1999-09-14 | |
US09/395,146 | 1999-09-14 | ||
PCT/US2000/025444 WO2001019817A2 (fr) | 1999-09-14 | 2000-09-14 | Composes d'ether 3-pyrrolidinyloxy-3'-pyridyle utilises comme regulateurs de la transmission synaptique chimique |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2381252A1 true CA2381252A1 (fr) | 2001-03-22 |
Family
ID=23561895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002381252A Abandoned CA2381252A1 (fr) | 1999-09-14 | 2000-09-14 | Composes d'ether 3-pyrrolidinyloxy-3'-pyridyle utilises comme regulateurs de la transmission synaptique chimique |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1212319A2 (fr) |
JP (1) | JP2003529547A (fr) |
CA (1) | CA2381252A1 (fr) |
MX (1) | MXPA02002115A (fr) |
WO (1) | WO2001019817A2 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2341989A1 (fr) | 1998-08-25 | 2000-03-02 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridyl ethers et thioethers tenant lieu de ligands pour le recepteur de l'acetycholine nicotinique, et application therapeutique |
DE10135043A1 (de) * | 2001-07-11 | 2003-01-30 | Bayer Cropscience Gmbh | Substituierte 3-Heteroaryl(amino- oder oxy)-pyrrolidin-2-one, Verfahren zu deren Herstellung und Verwendung als Herbizide oder als Pflanzenwachstumsregulatoren |
EP1463505A2 (fr) * | 2001-12-13 | 2004-10-06 | Abbott Laboratories | Derives de la 3-(phenyl-alkoxy)-5-(phenyl)-pyridine et composes similaires avec activite inhibiteur de kinase pour le traitement du cancer. |
US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
WO2003062235A1 (fr) * | 2002-01-17 | 2003-07-31 | Eli Lilly And Company | Modulateurs de recepteurs de l'acetylcholine |
WO2004014871A1 (fr) | 2002-08-08 | 2004-02-19 | Amgen Inc. | Ligands de recepteur vanilloide et leur utilisation dans des traitements |
US7659305B2 (en) | 2002-10-31 | 2010-02-09 | Pfizer Inc. | Therapeutic proline derivatives |
US7098331B2 (en) | 2003-03-05 | 2006-08-29 | Targacept, Inc. | Arylvinylazacycloalkane compounds and methods of preparation and use thereof |
AU2004278382B2 (en) * | 2003-09-30 | 2008-09-18 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
MY139645A (en) | 2004-02-11 | 2009-10-30 | Amgen Inc | Vanilloid receptor ligands and their use in treatments |
US7534798B2 (en) | 2004-02-11 | 2009-05-19 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
EP1735302B1 (fr) | 2004-02-27 | 2010-06-16 | Eli Lilly And Company | Derives de 4-amino-piperidine utilises en tant qu'inhibiteurs de l'absorption des monoamines |
WO2006089311A1 (fr) | 2005-02-15 | 2006-08-24 | Amgen Inc. | Ligands des recepteurs vanilloides et leurs utilisations therapeutiques |
KR100939347B1 (ko) | 2005-07-20 | 2010-01-29 | (주)카이로드 | 광학적으로 순수한 (s)-3-히드록시 피롤리딘의 제조방법 |
JP5528434B2 (ja) * | 2008-05-23 | 2014-06-25 | ジョージタウン ユニヴァーシティー | ニューロンnAChRの無痛性脱感作剤およびその使用方法 |
US8445684B2 (en) * | 2008-10-14 | 2013-05-21 | PsycoGenics Inc. | Nicotinic acetylcholine receptor ligands and the uses thereof |
AR075988A1 (es) | 2009-04-09 | 2011-05-11 | Lilly Co Eli | Compuesto de piridiloxi - pirrolidina inhibidor de recaptacion de serotonina y norepinefrina, composicion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de dolor cronico |
EP2509982A1 (fr) | 2009-12-07 | 2012-10-17 | Targacept, Inc. | 3,6-diazabicyclo[3.1.1]heptanes comme ligands des récepteurs nicotiniques neuronaux à l'acétycholine |
MX2012010491A (es) * | 2010-03-11 | 2013-01-25 | Targacept Inc | Compuestos arilvinilazacicloalcano para la constipacion. |
ES2903528T3 (es) * | 2016-10-10 | 2022-04-04 | Dong A Socio Holdings Co Ltd | Compuestos de heteroarilo y su uso como inhibidores de MER |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0107930B1 (fr) * | 1982-09-30 | 1990-11-28 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | Oxazépinones aromatiques condensées et analogues du soufre, leur préparation et utilisation comme antagonistes de l'histamine |
ZA848275B (en) * | 1983-12-28 | 1985-08-28 | Degussa | New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring |
US4667031A (en) * | 1985-10-15 | 1987-05-19 | Ethyl Corporation | Process for preparing oxazepinones |
IL107184A (en) * | 1992-10-09 | 1997-08-14 | Abbott Lab | Heterocyclic ether compounds that enhance cognitive function |
US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
JP2001522846A (ja) * | 1997-11-05 | 2001-11-20 | ニューロサーチ、アクティーゼルスカブ | アザ環−エーテル誘導体及びこれをニコチン性achレセプターモジュレーターとして使用する方法 |
CA2341989A1 (fr) * | 1998-08-25 | 2000-03-02 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridyl ethers et thioethers tenant lieu de ligands pour le recepteur de l'acetycholine nicotinique, et application therapeutique |
-
2000
- 2000-09-14 EP EP00965070A patent/EP1212319A2/fr not_active Withdrawn
- 2000-09-14 CA CA002381252A patent/CA2381252A1/fr not_active Abandoned
- 2000-09-14 MX MXPA02002115A patent/MXPA02002115A/es unknown
- 2000-09-14 JP JP2001523394A patent/JP2003529547A/ja not_active Withdrawn
- 2000-09-14 WO PCT/US2000/025444 patent/WO2001019817A2/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2001019817A3 (fr) | 2002-01-17 |
EP1212319A2 (fr) | 2002-06-12 |
WO2001019817A2 (fr) | 2001-03-22 |
JP2003529547A (ja) | 2003-10-07 |
MXPA02002115A (es) | 2002-10-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20020151712A1 (en) | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission | |
CA2381252A1 (fr) | Composes d'ether 3-pyrrolidinyloxy-3'-pyridyle utilises comme regulateurs de la transmission synaptique chimique | |
AU709784B2 (en) | 3-pyridyloxyalkyl heterocyclic ether compounds useful in controlling chemical synaptic transmission | |
AU773795B2 (en) | Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands | |
CA2256022C (fr) | Composes d'ethers 3-pyridyloxymethyle heterocycliques utilises dans la regulation de la transmission synaptique chimique | |
US7265115B2 (en) | Diazabicyclic CNS active agents | |
CA2315117C (fr) | Composes ether et thioether heterocycliques utilises dans la regulation de la transmission synaptique chimique | |
US20080090798A1 (en) | Heterocyclic Substituted Aminoazacycles Useful as Central Nervous System Agents | |
EP1178982A1 (fr) | Aminoazacycles heterocylcliques substitues utiles en tant qu'agents actifs sur le systeme nerveux central | |
US6437138B1 (en) | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission | |
US6656958B2 (en) | Substituted pyridine compounds useful for controlling chemical synaptic transmission | |
EP1257535B1 (fr) | Composes pyridine substitues utiles dans la regulation de la transmission synaptique chimique | |
MXPA99007626A (en) | 7a-HETEROCYCLE-SUBSTITUTED HEXAHYDRO-1H-PYRROLIZINE COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | |
ZA200109162B (en) | Heterocyclic substituted aminoazacycles useful as central nervous system agents. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |