CA2380202A1

CA2380202A1 - Nouvelles formes brutes et cristallines de chlorhydrate de lercanidipine

Nouvelles formes brutes et cristallines de chlorhydrate de lercanidipine Download PDF

Info

Publication number: CA2380202A1
Authority: CA; Canada
Prior art keywords: lercanidipine hydrochloride; crude; lercanidipine; solid; solvent
Prior art date: 2001-08-06
Legal status : Abandoned

Application number

CA 2380202

Other languages

English (en)

Inventor

Francesco Campana

Fausto Bonifacio

Amedeo Leonardi

Gianluca De Iasi

Current Assignee

Recordati Ireland Ltd

Original Assignee

Individual

Priority date

2001-08-06

Filing date

2002-04-03

Publication date

2003-02-06

2001-08-06 Priority claimed from IT2001MI001726A external-priority patent/ITMI20011726A1/it

2002-04-03 Application filed by Individual filed Critical Individual

2002-08-06 Priority to CA 2399583 priority Critical patent/CA2399583A1/fr

2002-08-06 Priority to CA2399459A priority patent/CA2399459C/fr

2003-02-06 Publication of CA2380202A1 publication Critical patent/CA2380202A1/fr

Status Abandoned legal-status Critical Current

Links

WMFYOYKPJLRMJI-UHFFFAOYSA-N Lercanidipine hydrochloride Chemical compound Cl.COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 WMFYOYKPJLRMJI-UHFFFAOYSA-N 0.000 title claims abstract description 205
229960002162 lercanidipine hydrochloride Drugs 0.000 title claims abstract description 149
238000000034 method Methods 0.000 claims abstract description 128
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 22
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 82
239000000203 mixture Substances 0.000 claims description 79
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 70
239000007787 solid Substances 0.000 claims description 61
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 52
239000002904 solvent Substances 0.000 claims description 42
229960004294 lercanidipine Drugs 0.000 claims description 41
238000003756 stirring Methods 0.000 claims description 40
ZDXUKAKRHYTAKV-UHFFFAOYSA-N lercanidipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZDXUKAKRHYTAKV-UHFFFAOYSA-N 0.000 claims description 38
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OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 18
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