CA2378477A1 - Induction de la tolerance immunitaire - Google Patents
Induction de la tolerance immunitaire Download PDFInfo
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- CA2378477A1 CA2378477A1 CA002378477A CA2378477A CA2378477A1 CA 2378477 A1 CA2378477 A1 CA 2378477A1 CA 002378477 A CA002378477 A CA 002378477A CA 2378477 A CA2378477 A CA 2378477A CA 2378477 A1 CA2378477 A1 CA 2378477A1
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/445—Plasmodium
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
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- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
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- C12N2501/20—Cytokines; Chemokines
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
On décrit des procédés et des compositions qui permettent d'induire une tolérance immunitaire dans des cellules de présentation d'antigène de mammifère telles que des cellules dendritiques, des macrophages, des monocytes et des lymphocytes B. Ces procédés et ces compostions impliquent l'utilisation d'agonistes des récepteurs de surface cellulaire CD36, CD51, des récepteurs de thrombospondine et/ou des Bêta intégrines qui, une fois exposés à une cellule présentant l'antigène telle qu'une cellule dendritique sont capables d'inhiber la maturation dans ces derniers. Par conséquent l'aptitude des cellules à favoriser la réponse immunitaire est inhibée. La tolérance à un antigène spécifique peut être induite dans des cellules présentant l'antigène au moyen de l'exposition à un ou plusieurs agonistes précités et à l'antigène. Des préparations de cellules peuvent ainsi être préparées pour être administrées à des humains chez qui la tolérance à un ou plusieurs antigènes spécifiques doit être induite, par exemple en cas de transplants d'allogreffes ou de xénogreffes ou en cas de maladie auto-immune.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9915311.6 | 1999-06-30 | ||
GBGB9915311.6A GB9915311D0 (en) | 1999-06-30 | 1999-06-30 | Modulation of dendritic cell maturation |
PCT/GB2000/002546 WO2001002005A2 (fr) | 1999-06-30 | 2000-06-30 | Induction de la tolerance immunitaire |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2378477A1 true CA2378477A1 (fr) | 2001-01-11 |
Family
ID=10856356
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002378477A Abandoned CA2378477A1 (fr) | 1999-06-30 | 2000-06-30 | Induction de la tolerance immunitaire |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1196543A2 (fr) |
AU (1) | AU5695200A (fr) |
CA (1) | CA2378477A1 (fr) |
GB (1) | GB9915311D0 (fr) |
WO (1) | WO2001002005A2 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012135550A1 (fr) * | 2011-03-30 | 2012-10-04 | Luna Innovations Incorporated | Agents de contraste ciblant un biomarqueur et leur utilisation en imagerie par résonance magnétique pour détection de plaque d'athérosclérose |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0477270A1 (fr) * | 1989-06-15 | 1992-04-01 | Med-Tal, Inc. | Prophylaxie et traitement d'infections microbiennes avec des phosphoglycerides |
AU2795892A (en) * | 1991-10-03 | 1993-05-03 | Center For Blood Research, The | Cd36 immunoadhesins and their use in selectively killing (plasmodium falciparum) infected erythrocytes |
JPH09505555A (ja) * | 1993-08-13 | 1997-06-03 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ,アズ リプレゼンテッド バイ ザ セクレタリー,デパートメント オブ ヘルス アンド ヒューマン サービシーズ | TGF−βの活性を刺激および阻害する方法および組成物 |
AU5851296A (en) * | 1995-04-27 | 1996-11-18 | Affymax Technologies N.V. | Malaria peptides and vaccines |
-
1999
- 1999-06-30 GB GBGB9915311.6A patent/GB9915311D0/en not_active Ceased
-
2000
- 2000-06-30 EP EP00942249A patent/EP1196543A2/fr not_active Withdrawn
- 2000-06-30 WO PCT/GB2000/002546 patent/WO2001002005A2/fr not_active Application Discontinuation
- 2000-06-30 CA CA002378477A patent/CA2378477A1/fr not_active Abandoned
- 2000-06-30 AU AU56952/00A patent/AU5695200A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2001002005A2 (fr) | 2001-01-11 |
EP1196543A2 (fr) | 2002-04-17 |
AU5695200A (en) | 2001-01-22 |
GB9915311D0 (en) | 1999-09-01 |
WO2001002005A3 (fr) | 2001-07-05 |
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