CA2372595A1 - Compositions contraceptives contenant des derives d'indoline et des agents progestatifs - Google Patents

Compositions contraceptives contenant des derives d'indoline et des agents progestatifs Download PDF

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Publication number
CA2372595A1
CA2372595A1 CA002372595A CA2372595A CA2372595A1 CA 2372595 A1 CA2372595 A1 CA 2372595A1 CA 002372595 A CA002372595 A CA 002372595A CA 2372595 A CA2372595 A CA 2372595A CA 2372595 A1 CA2372595 A1 CA 2372595A1
Authority
CA
Canada
Prior art keywords
indol
cyclohexane
dihydro
mmol
phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002372595A
Other languages
English (en)
Inventor
Gary S. Grubb
Lin Zhi
Todd K. Jones
Christopher M. Tegley
Andrew Fensome
Lori L. Miller
John W. Ullrich
Reinhold H. W. Bender
Puwen Zhang
Jay E. Wrobel
James P. Edwards
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Ligand Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/552,358 external-priority patent/US6462032B1/en
Application filed by Individual filed Critical Individual
Publication of CA2372595A1 publication Critical patent/CA2372595A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des thérapies et des traitements cycliques combinés utilisant des composés de dérivés d'indoline substitués qui constituent des antagonistes du récepteur de la progestérone, et sont représentés par la structure générale (1). Dans la formule, R?1¿ et R?2¿ peuvent être des substituants uniques ou condensés de façon à former des noyaux spirocycliques, et sont combinés à des progestatifs et/ou à des oestrogènes. Ces méthodes de traitement peuvent servir de contraception ou pour traiter et/ou prévenir l'aménorrhée secondaire, les saignements anormaux, le léiomyome de l'utérus, l'endométriose, le syndrome des ovaires polycystiques, les carcinomes et adénocarcinomes de l'endomètre, de l'ovaire, du sein, du côlon et de la prostate, ou pour réduire au minimum les saignements du cycle menstruel ou leurs effets secondaires. L'invention comporte des applications supplémentaires telles que la stimulation de l'appétit en vue d'augmenter l'apport d'aliments.
CA002372595A 1999-05-04 2000-05-01 Compositions contraceptives contenant des derives d'indoline et des agents progestatifs Abandoned CA2372595A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18305299P 1999-05-04 1999-05-04
US60/183,052 1999-05-04
US09/552,358 US6462032B1 (en) 1999-05-04 2000-04-19 Cyclic regimens utilizing indoline derivatives
US09/552,358 2000-04-19
PCT/US2000/011834 WO2000066167A1 (fr) 1999-05-04 2000-05-01 Compositions contraceptives contenant des derives d'indoline et des agents progestatifs

Publications (1)

Publication Number Publication Date
CA2372595A1 true CA2372595A1 (fr) 2000-11-09

Family

ID=26878702

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002372595A Abandoned CA2372595A1 (fr) 1999-05-04 2000-05-01 Compositions contraceptives contenant des derives d'indoline et des agents progestatifs

Country Status (6)

Country Link
EP (1) EP1173212A1 (fr)
JP (1) JP2002543158A (fr)
CN (1) CN1349416A (fr)
AU (1) AU4813900A (fr)
CA (1) CA2372595A1 (fr)
MX (1) MXPA01011296A (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0510260A (pt) 2004-04-27 2007-10-23 Wyeth Corp método para purificar um composto, e, kit farmacêutico
EP1774970A1 (fr) * 2005-10-13 2007-04-18 Bayer Schering Pharma AG Méthode pour la préparation d'une composition pharmaceutique contenant d'ethinyloestradiol et du dienogest pour le traitement d'hemorragies uterines dysfonctionelles
DE102008022221A1 (de) * 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
WO2017000082A1 (fr) * 2015-06-30 2017-01-05 上海交通大学 Utilisation du lévonorgestrel dans la préparation d'un produit permettant de lutter contre le cancer de l'ovaire
CN105012314B (zh) * 2015-06-30 2017-12-08 上海交通大学 Etonogestrel在制备抗前列腺癌产品中的应用
US10864220B2 (en) * 2015-06-30 2020-12-15 Shanghai Jiao Tong University Applications of desogestrel in the preparation of anti-colon cancer/breast cancer ER-negative Ah receptor-positive products
WO2017000081A1 (fr) * 2015-06-30 2017-01-05 上海交通大学 Utilisation de l'étonorgestrel dans la préparation d'un produit permettant de lutter contre l'adénocarcinome de la prostate

Also Published As

Publication number Publication date
MXPA01011296A (es) 2003-07-14
JP2002543158A (ja) 2002-12-17
CN1349416A (zh) 2002-05-15
AU4813900A (en) 2000-11-17
EP1173212A1 (fr) 2002-01-23

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Legal Events

Date Code Title Description
FZDE Discontinued