CA2372559A1 - Croissance et guidage des neurites par la tenascine-c - Google Patents

Croissance et guidage des neurites par la tenascine-c Download PDF

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Publication number
CA2372559A1
CA2372559A1 CA002372559A CA2372559A CA2372559A1 CA 2372559 A1 CA2372559 A1 CA 2372559A1 CA 002372559 A CA002372559 A CA 002372559A CA 2372559 A CA2372559 A CA 2372559A CA 2372559 A1 CA2372559 A1 CA 2372559A1
Authority
CA
Canada
Prior art keywords
tenascin
peptide
fna
region
guidance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002372559A
Other languages
English (en)
Inventor
Herbert M. Geller
Sally Meiners
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
University of Medicine and Dentistry of New Jersey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Medicine and Dentistry of New Jersey filed Critical University of Medicine and Dentistry of New Jersey
Publication of CA2372559A1 publication Critical patent/CA2372559A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

On a mis au point une méthode de dosage permettant de quantifier le comportement des neurites au niveau de limites étroites entre substrats et on a trouvé que les neurites manifestent une forte préférence pour fnA-D, lorsqu'ils ont le choix à l'interface entre poly-L-lysine et fnA-D. En outre, les neurites préfèrent les cellules qui surexpriment le plus grand variant d'épissage de ténascine-C, plutôt que le plus petit, lorsqu'ils ont le choix entre des cellules témoins et des cellules transfectées par de la ténascine-C. Les marques de guidage permissives de la ténascine-C de grande taille exprimées par ces cellules ont fait l'objet d'un mappage sur fnA-D. On a démontré que la croissance et le guidage des neurites sont facilités par des séquences distinctes dans fnA-D. Par conséquent, la croissance des neurites et leur guidage par l'intermédiaire d'une région de ténascine-C ayant fait l'objet d'un autre type d'épissage sont des événements séparables qui peuvent être régulés de façon indépendante.
CA002372559A 1999-05-01 2000-04-28 Croissance et guidage des neurites par la tenascine-c Abandoned CA2372559A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13213799P 1999-05-01 1999-05-01
US60/132,137 1999-05-01
PCT/US2000/011647 WO2000066628A1 (fr) 1999-05-01 2000-04-28 Croissance et guidage des neurites par la tenascine-c

Publications (1)

Publication Number Publication Date
CA2372559A1 true CA2372559A1 (fr) 2000-11-09

Family

ID=22452654

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002372559A Abandoned CA2372559A1 (fr) 1999-05-01 2000-04-28 Croissance et guidage des neurites par la tenascine-c

Country Status (6)

Country Link
EP (1) EP1175441A1 (fr)
JP (1) JP2003512300A (fr)
AU (1) AU4682100A (fr)
CA (1) CA2372559A1 (fr)
MX (1) MXPA01011230A (fr)
WO (1) WO2000066628A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20040105A1 (it) * 2004-02-27 2004-05-27 Tecnogen Scpa Anticorpo monoclonale antitenascina umana.
US20060115862A1 (en) * 2004-11-17 2006-06-01 Duke University Anti-tenascin monoclonal antibody immunoassays and diagnostic kits
FR2944020B1 (fr) * 2009-04-02 2011-06-10 Etat Francais Ministere De La Defense Service De Sante Des Armees Peptides fusion pour le traitement de traumatismes ou de maladies affectant le systeme nerveux central

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007872A1 (fr) * 1990-10-29 1992-05-14 California Institute Of Biological Research Peptides apparentes a la tenascine
EP0781297A4 (fr) * 1994-09-16 1999-05-19 Scripps Research Inst Derives de cytotactine stimulant la connexion neuronale et la croissance des axones et des dendrites, leurs procedes de preparation et d'utilisation

Also Published As

Publication number Publication date
MXPA01011230A (es) 2002-10-04
WO2000066628A1 (fr) 2000-11-09
EP1175441A1 (fr) 2002-01-30
JP2003512300A (ja) 2003-04-02
AU4682100A (en) 2000-11-17

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Legal Events

Date Code Title Description
FZDE Discontinued