CA2370358A1 - Use of osseo-promotive membranes in orthopaedics - Google Patents
Use of osseo-promotive membranes in orthopaedics Download PDFInfo
- Publication number
- CA2370358A1 CA2370358A1 CA002370358A CA2370358A CA2370358A1 CA 2370358 A1 CA2370358 A1 CA 2370358A1 CA 002370358 A CA002370358 A CA 002370358A CA 2370358 A CA2370358 A CA 2370358A CA 2370358 A1 CA2370358 A1 CA 2370358A1
- Authority
- CA
- Canada
- Prior art keywords
- bone
- membrane
- use according
- layer
- injury
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30721—Accessories
- A61F2/30742—Bellows or hose-like seals; Sealing membranes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
- A61F2/36—Femoral heads ; Femoral endoprostheses
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
- A61F2002/30011—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in porosity
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30448—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30462—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements retained or tied with a rope, string, thread, wire or cable
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30589—Sealing means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
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- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
- A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
Abstract
The use of an occlusive or semi-occlusive membrane is described for promotio n of bone growth in orthopaedic surgery, wherein a bone injury is sealed by closing the injury with a membrane which is substantially inert to body flui ds and is adapted to prevent ingrowth of fibrous tissue into said injury. Preferably, the membrane is a laminate of at least two layers comprising a first layer having openings of a size which are adapted to be penetrated by fibrous soft tissue, and a second layer which is non-porous or has pores whi ch are too small to be penetrated by soft tissue, the second layer being adapte d to lie adjacent the bone injury.
Description
USE OF OSSEO-PROMOTIVE MEMBRANES IN ORTHOPAEDICS
This invention relates to the use of osseo-promotive membranes in regeneration of bone where the bone has been injured by disease, accident or surgery.
In our PCT application WO 95/10990, the use of a microporous membrane is described for sealing the junction between an implanted hip prosthesis and the bone to exclude wear particles generated by articulation of the prosthesis. Further research has shown that the sealing of bone injuries using occlusive or semi-occlusive membranes so as to exclude soft tissue cells promotes the ingrowth of the bone in the region of the injury.
According to one aspect the present invention provides for use of an occlusive or semi-occlusive membrane in the manufacture of a device for the promotion of bone ingrowth in orthopaedic surgery, wherein a bone injury is sealed by closing said injury with a membrane which is substantially inert to body fluids and is adapted to prevent ingrowth of fibrous tissues into said injury.
Preferably, the membrane is a polymer of a fluorinated monomer and may be totally non-porous to body fluids or may be semi-permeable. Where the membrane is semi-permeable, the pore sizes should not exceed 250 microns and, preferably, should not exceed 200 microns. A suitable range of pore sizes is from 0.5 micron to microns.
The membrane should be bio-compatible and essentially inert to body fluids.
Preferred materials are fluorinated olefins, especially perffuorinated olefins, e.g.
perfluorinated ethylene and propylene. Polytetrafluoroethylene is currently preferred.
This invention relates to the use of osseo-promotive membranes in regeneration of bone where the bone has been injured by disease, accident or surgery.
In our PCT application WO 95/10990, the use of a microporous membrane is described for sealing the junction between an implanted hip prosthesis and the bone to exclude wear particles generated by articulation of the prosthesis. Further research has shown that the sealing of bone injuries using occlusive or semi-occlusive membranes so as to exclude soft tissue cells promotes the ingrowth of the bone in the region of the injury.
According to one aspect the present invention provides for use of an occlusive or semi-occlusive membrane in the manufacture of a device for the promotion of bone ingrowth in orthopaedic surgery, wherein a bone injury is sealed by closing said injury with a membrane which is substantially inert to body fluids and is adapted to prevent ingrowth of fibrous tissues into said injury.
Preferably, the membrane is a polymer of a fluorinated monomer and may be totally non-porous to body fluids or may be semi-permeable. Where the membrane is semi-permeable, the pore sizes should not exceed 250 microns and, preferably, should not exceed 200 microns. A suitable range of pore sizes is from 0.5 micron to microns.
The membrane should be bio-compatible and essentially inert to body fluids.
Preferred materials are fluorinated olefins, especially perffuorinated olefins, e.g.
perfluorinated ethylene and propylene. Polytetrafluoroethylene is currently preferred.
Where the membrane is semi-permeable, an expanded polytetrafluoroethylene is preferred.
Methods of producing such a membrane are known and described, for example, in US Patents Nos. 3,953,566 and 4,187,390. An example of one commercially available and suitable product is the micro-porous PTFE material manufactured by W. L. Gore Associates Ltd., under the trade mark "Gortex e-PTFE".
In one embodiment of the invention the membrane is a laminate of at least two layers of material. One of the layers may have a pore size which is large enough to be penetrated by soft, fibrous tissue cells, e.g. at a size greater than 250 microns. An adjacent layer may be totally occlusive or have much smaller pore openings so that fibrous soft tissue cells cannot penetrate the second layer. Typically, the membrane, whether a single sheet or a laminate, may be up to about 1 to 1.5 mm thick, preferably from about 300 to 1000 microns thick. In use, the occlusive or semi-occlusive layer having small particle sizes is positioned adjacent the bone injury so that soft fibrous cells cannot penetrate into the space created and sealed off by the membrane.
Preferably, the laminate comprises at least three layers, the layer adjacent the bone injury is occlusive or contains only pore openings having an average size less than 250 microns, preferably less than 200 microns. A three-layer laminate in which the control layer has the smaller pore size is preferred, since it is symmetrical and can be used reversibly. Similarly, multi-layer laminates in which the outer layers are of the same or similar larger pore sizes are also advantageous. In two layer or mufti-layer membranes, the layers are preferably welded together.
Methods of producing such a membrane are known and described, for example, in US Patents Nos. 3,953,566 and 4,187,390. An example of one commercially available and suitable product is the micro-porous PTFE material manufactured by W. L. Gore Associates Ltd., under the trade mark "Gortex e-PTFE".
In one embodiment of the invention the membrane is a laminate of at least two layers of material. One of the layers may have a pore size which is large enough to be penetrated by soft, fibrous tissue cells, e.g. at a size greater than 250 microns. An adjacent layer may be totally occlusive or have much smaller pore openings so that fibrous soft tissue cells cannot penetrate the second layer. Typically, the membrane, whether a single sheet or a laminate, may be up to about 1 to 1.5 mm thick, preferably from about 300 to 1000 microns thick. In use, the occlusive or semi-occlusive layer having small particle sizes is positioned adjacent the bone injury so that soft fibrous cells cannot penetrate into the space created and sealed off by the membrane.
Preferably, the laminate comprises at least three layers, the layer adjacent the bone injury is occlusive or contains only pore openings having an average size less than 250 microns, preferably less than 200 microns. A three-layer laminate in which the control layer has the smaller pore size is preferred, since it is symmetrical and can be used reversibly. Similarly, multi-layer laminates in which the outer layers are of the same or similar larger pore sizes are also advantageous. In two layer or mufti-layer membranes, the layers are preferably welded together.
While the membranes can be sutured to bone or tissue to seal off the injured site, the inventors have discovered that one effective procedure is to adhesively bond the edges of the membrane around the perimeter of the injury. Suitable adhesives include medical grade cyanoacrylate polymers (commonly known as super glues), and the adhesive material sold under the trade mark "Histoacryl blue" by B. Braun Melsungen A.G. is currently preferred.
Another method of sealing the ends of the membrane is to pass a ligature, such as a loop of metal wire, around the bone and to tighten the loop around the base.
Alternative methods of fixing the membrane to the bone include staples or pins. Of course, a combination of these fixing methods may be employed.
It has been found to be advantageous in use to employ a semi-occlusive membrane or one which has a layer partially or wholly penetrable by fibrous, soft tissue cells since the ingrowth of soft tissue cells into a membrane, but not through it, helps to stabilise the seal and hold the seal in place after the suturing or adhesive bond has aged.
Examples of the use of the occlusive or semi-occlusive membranes of the invention will now be described with reference to the accompanying drawings, in which:-Figure 1 A shows a section through a hip prosthesis inserted in a femur;
Figure 1 B shows a similar view with a membrane fitted over and sealing the gap between the prosthesis and the hole formed to receive the bone;
Figure 2A shows a bone which has suffered a severe fracture;
Another method of sealing the ends of the membrane is to pass a ligature, such as a loop of metal wire, around the bone and to tighten the loop around the base.
Alternative methods of fixing the membrane to the bone include staples or pins. Of course, a combination of these fixing methods may be employed.
It has been found to be advantageous in use to employ a semi-occlusive membrane or one which has a layer partially or wholly penetrable by fibrous, soft tissue cells since the ingrowth of soft tissue cells into a membrane, but not through it, helps to stabilise the seal and hold the seal in place after the suturing or adhesive bond has aged.
Examples of the use of the occlusive or semi-occlusive membranes of the invention will now be described with reference to the accompanying drawings, in which:-Figure 1 A shows a section through a hip prosthesis inserted in a femur;
Figure 1 B shows a similar view with a membrane fitted over and sealing the gap between the prosthesis and the hole formed to receive the bone;
Figure 2A shows a bone which has suffered a severe fracture;
Figure 2B depicts the invasion of soft tissue into the fracture hindering bone regeneration;
Figure 2C illustrates bone formation promoted by fitting of a membrane around the injury;
Figure 3A illustrates bone defect caused by surgery to remove a tumour in which a prosthesis has been fitted to replace the bone which has been removed;
Figure 3B illustrates the use of a membrane to promote bone growth.
Figure 4A illustrates the situation where an intramedullary rod has been inserted into a bone;
Figure 4B illustrates the use of a membrane to prevent fibrous tissue ingrowth.
Referring to Figures 1 A and 1 B, these Figures illustrate the situation in which a hip replacement prosthesis has been inserted into a femur (2) leaving a junction (3) between the edge of the hole cut in the head of the femur and the prosthesis.
It has been found that especially where the prosthesis does not fit snugly into the canal cut in the femur or where bone cement is used, this can sometimes shrink away from the prosthesis or the hole cut in the bone, thus enabling fibrous tissue cells to enter the interior of the bone. In time, this will generate an ingrowth of soft tissue within the spaces between the bone and the prosthesis which is indicated at (4), which prevents generation of bone in these areas. By fitting an occlusive or semi-occlusive membrane of the kind described above to seal completely any existing or possibly future gaps forming between the prosthesis and the bone (indicated at (5) in Figure 1B), the intrusion of fibrous tissue in the space between the prosthesis and the bone is prevented. This will promote in time the slower rate of ingrowth of bone in the areas S
indicated at (6) in Figure 1B, and this will maintain the stability of the prosthesis and, in time, the bone ingrowth may further lock the prosthesis into place.
The membranes used in accordance with the present invention may be resorbable over time but this is not essential and the polyfluorinated membranes described above are generally not resorbable. This is not a disadvantage since these materials have long term bio-compatibility. The presence of the membrane overlaying the fracture area creates a beneficial environment beneath the membrane for bone formation. This results in a lower incidence of delayed union or non-union of the bone with the surface of the prosthesis. The edges of the membrane are preferably bonded to the bone and to the prosthesis, e.g. by means of an adhesive, preferably a cyanoacrylate adhesive.
Referring to Figures 2A to 2C, this illustrates the use of the membrane to promote the growth of bone to repair a fracture. In the case of severe and compound fractures where the bone has been broken into small segments or splintered, regenerative bone ingrowth is slow and it may be necessary to insert one or more surgical pins, nails or rods, to hold the fragments of bone together. Even with such devices, after the surgical repair there are a number of gaps or openings into the interior of the bone into which soft tissue cells can penetrate. Where such tissue does enter the bone, it can prevent or substantially reduce the rate at which bone ingrowth will occur to form a long term healing of the fracture.
In accordance with this invention, this process is promoted and speeded up by creating an enclosed fracture site (10) after fixing the fragments in place using an occlusive or semi-occlusive membrane (11). The membrane (11) may be sealed to its self and to the upper and lower portions of the bone to prevent ingress of fibrous tissue material into the fracture site. By preventing the competitive growth of fibrous tissue within the injured bone by sealing the cavity with the resorbable or non-resorbable membrane, bone formation will be promoted. In addition, the membrane will confine growth factors present in the bone and other bone-inducible agents or materials such as an altograft or autograft to the defect site and in the vicinity of the healing bone. For large implants or complex nailing and pinning, one of the advantages will be that increased bone growth will result in a decrease in the loosening of the implant or fixing device.
Figures 3A and 3B illustrate the application of the invention to surgical treatment of bone tumour. Refernng to Figure 3A, a bone (20) has been cut away to remove the tumour and a replacement implant (21 ) fitted into the healthy bone. In this embodiment, the implant (21 ) having a fixing stem (21 a) may be fitted into the healthy bone using a bone cement (22), and the implant may be provided with a surface treatment of hydroxy-apatite, especially to the stem, to promote bonding of the bone to the surface of the implant. A blood clot may form or be artificially induced at the junction (23) between the implant and the bone and this area is sealed as shown in Figure 3B by wrapping the area with a membrane (24). The membrane (24) is fixed as by gluing to the implant and to the bone to create a space (25) within which bone growth is promoted to bond the healthy bone to the implant. Alternatively, the membrane may be sealed around the bone by positioning wires ( 1 O 1 ) & ( 102) around the ends of the membrane and tensioning the wires to form seals between the membrane and the bone or implant.
Figures 4A and 4B illustrate a similar use of the membranes in accordance with the invention in which an intramedullary rod having an hydroxy apatite coated collar (31 ) having a fixing stem (31 a) is introduced into a damaged bone (30) using a bone cement (32). Again, a blood clot material (33) is formed or induced around the junction between the intramedullaiy rod and the bone and this area is wrapped with a membrane (34) in accordance with the invention.
Figure 2C illustrates bone formation promoted by fitting of a membrane around the injury;
Figure 3A illustrates bone defect caused by surgery to remove a tumour in which a prosthesis has been fitted to replace the bone which has been removed;
Figure 3B illustrates the use of a membrane to promote bone growth.
Figure 4A illustrates the situation where an intramedullary rod has been inserted into a bone;
Figure 4B illustrates the use of a membrane to prevent fibrous tissue ingrowth.
Referring to Figures 1 A and 1 B, these Figures illustrate the situation in which a hip replacement prosthesis has been inserted into a femur (2) leaving a junction (3) between the edge of the hole cut in the head of the femur and the prosthesis.
It has been found that especially where the prosthesis does not fit snugly into the canal cut in the femur or where bone cement is used, this can sometimes shrink away from the prosthesis or the hole cut in the bone, thus enabling fibrous tissue cells to enter the interior of the bone. In time, this will generate an ingrowth of soft tissue within the spaces between the bone and the prosthesis which is indicated at (4), which prevents generation of bone in these areas. By fitting an occlusive or semi-occlusive membrane of the kind described above to seal completely any existing or possibly future gaps forming between the prosthesis and the bone (indicated at (5) in Figure 1B), the intrusion of fibrous tissue in the space between the prosthesis and the bone is prevented. This will promote in time the slower rate of ingrowth of bone in the areas S
indicated at (6) in Figure 1B, and this will maintain the stability of the prosthesis and, in time, the bone ingrowth may further lock the prosthesis into place.
The membranes used in accordance with the present invention may be resorbable over time but this is not essential and the polyfluorinated membranes described above are generally not resorbable. This is not a disadvantage since these materials have long term bio-compatibility. The presence of the membrane overlaying the fracture area creates a beneficial environment beneath the membrane for bone formation. This results in a lower incidence of delayed union or non-union of the bone with the surface of the prosthesis. The edges of the membrane are preferably bonded to the bone and to the prosthesis, e.g. by means of an adhesive, preferably a cyanoacrylate adhesive.
Referring to Figures 2A to 2C, this illustrates the use of the membrane to promote the growth of bone to repair a fracture. In the case of severe and compound fractures where the bone has been broken into small segments or splintered, regenerative bone ingrowth is slow and it may be necessary to insert one or more surgical pins, nails or rods, to hold the fragments of bone together. Even with such devices, after the surgical repair there are a number of gaps or openings into the interior of the bone into which soft tissue cells can penetrate. Where such tissue does enter the bone, it can prevent or substantially reduce the rate at which bone ingrowth will occur to form a long term healing of the fracture.
In accordance with this invention, this process is promoted and speeded up by creating an enclosed fracture site (10) after fixing the fragments in place using an occlusive or semi-occlusive membrane (11). The membrane (11) may be sealed to its self and to the upper and lower portions of the bone to prevent ingress of fibrous tissue material into the fracture site. By preventing the competitive growth of fibrous tissue within the injured bone by sealing the cavity with the resorbable or non-resorbable membrane, bone formation will be promoted. In addition, the membrane will confine growth factors present in the bone and other bone-inducible agents or materials such as an altograft or autograft to the defect site and in the vicinity of the healing bone. For large implants or complex nailing and pinning, one of the advantages will be that increased bone growth will result in a decrease in the loosening of the implant or fixing device.
Figures 3A and 3B illustrate the application of the invention to surgical treatment of bone tumour. Refernng to Figure 3A, a bone (20) has been cut away to remove the tumour and a replacement implant (21 ) fitted into the healthy bone. In this embodiment, the implant (21 ) having a fixing stem (21 a) may be fitted into the healthy bone using a bone cement (22), and the implant may be provided with a surface treatment of hydroxy-apatite, especially to the stem, to promote bonding of the bone to the surface of the implant. A blood clot may form or be artificially induced at the junction (23) between the implant and the bone and this area is sealed as shown in Figure 3B by wrapping the area with a membrane (24). The membrane (24) is fixed as by gluing to the implant and to the bone to create a space (25) within which bone growth is promoted to bond the healthy bone to the implant. Alternatively, the membrane may be sealed around the bone by positioning wires ( 1 O 1 ) & ( 102) around the ends of the membrane and tensioning the wires to form seals between the membrane and the bone or implant.
Figures 4A and 4B illustrate a similar use of the membranes in accordance with the invention in which an intramedullary rod having an hydroxy apatite coated collar (31 ) having a fixing stem (31 a) is introduced into a damaged bone (30) using a bone cement (32). Again, a blood clot material (33) is formed or induced around the junction between the intramedullaiy rod and the bone and this area is wrapped with a membrane (34) in accordance with the invention.
Claims (11)
1. Use of an occlusive or semi-occlusive membrane in the manufacture of a device for promotion of bone growth in orthopaedic surgery, wherein a bone injury is sealed by closing said injury with a membrane which is substantially inert to body fluids and is adapted to prevent ingrowth of fibrous tissue into said injury.
2. Use according to claim 1 in which the membrane is a polymer of a fluorinated monomer.
3. Use according to claim 1 or 2 wherein the membrane is a semi-permeable membrane having average pore sizes of not more than 250 microns.
4. Use according to claim 3 wherein the average pore size is between about 0.5 micron and 200 microns.
5. Use according to any one of the preceding claims wherein the device includes an adhesive layer for bonding edges of the membrane to tissue around the bone injury.
6. Use according to claim 5 wherein the adhesive is a cyanoacrylate adhesive.
7. Use according to any one of claims 1 to 4 in which the device includes a ligature for holding the membrane in intimate contact with bone or an implant.
8. Use according to any one of the preceding claims in which the membrane is a laminate of at least two layers comprising a first layer having openings of a size which are adapted to be penetrated by fibrous soft tissue, and a second layer which is non-porous or has pores which are too small to be penetrated by soft tissue, the second layer being adapted to lie adjacent the bone injury.
9. Use according to claim 8 wherein the laminate comprises at least three layers, and wherein the first layer comprises an internal layer and the second layers lie outside said first layer.
10. Use according to any one of the preceding claims wherein the bone injury is caused by a fracture or surgical removal of bone following diagnosis of a bone tumour.
11. Use according to any one of the preceding claims wherein the bone injury is caused by surgical insertion of a prosthesis, nail or rod.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9908638.1 | 1999-04-15 | ||
GBGB9908638.1A GB9908638D0 (en) | 1999-04-15 | 1999-04-15 | Use of osseo-promotive membranes in orthopaedics |
PCT/GB2000/001349 WO2000062707A2 (en) | 1999-04-15 | 2000-04-10 | Use of osseo-promotive membranes in orthopaedics |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2370358A1 true CA2370358A1 (en) | 2000-10-26 |
Family
ID=10851601
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002370358A Abandoned CA2370358A1 (en) | 1999-04-15 | 2000-04-10 | Use of osseo-promotive membranes in orthopaedics |
Country Status (5)
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EP (1) | EP1168983A2 (en) |
AU (1) | AU3979700A (en) |
CA (1) | CA2370358A1 (en) |
GB (1) | GB9908638D0 (en) |
WO (1) | WO2000062707A2 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7592017B2 (en) | 2000-03-10 | 2009-09-22 | Mast Biosurgery Ag | Resorbable thin membranes |
US20030097180A1 (en) * | 2001-11-20 | 2003-05-22 | Pertti Tormala | Joint prosthesis |
CA2419831A1 (en) * | 2002-02-28 | 2003-08-28 | Macropore Biosurgery, Inc. | Methods for governing bone growth |
US8048444B2 (en) | 2002-07-31 | 2011-11-01 | Mast Biosurgery Ag | Apparatus and method for preventing adhesions between an implant and surrounding tissues |
CA2494230C (en) | 2002-07-31 | 2012-03-06 | Macropore Biosurgery, Inc. | Apparatus and method for preventing adhesions between an implant and surrounding tissues |
US7704520B1 (en) | 2002-09-10 | 2010-04-27 | Mast Biosurgery Ag | Methods of promoting enhanced healing of tissues after cardiac surgery |
JP4529410B2 (en) * | 2003-10-23 | 2010-08-25 | 株式会社ジェイ・エム・エス | Culture carrier, culture using the culture carrier, and method for producing the culture |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
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SE392582B (en) | 1970-05-21 | 1977-04-04 | Gore & Ass | PROCEDURE FOR THE PREPARATION OF A POROST MATERIAL, BY EXPANDING AND STRETCHING A TETRAFLUORETENE POLYMER PREPARED IN AN PASTE-FORMING EXTENSION PROCEDURE |
GB9321700D0 (en) | 1993-10-21 | 1993-12-15 | Barrett David | Bone implants |
DE4414675C1 (en) * | 1994-04-27 | 1995-09-28 | Kirsch Axel | Covering device for bone defects and method for their production |
CA2185237C (en) * | 1995-02-14 | 2000-06-20 | Andrew B. Berman | Apparatus and method for protecting prosthetic joint assembly from wear debris |
DE19520866C2 (en) * | 1995-06-08 | 1998-04-16 | Kirsch Axel | Device for treating a bone recess |
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1999
- 1999-04-15 GB GBGB9908638.1A patent/GB9908638D0/en not_active Ceased
-
2000
- 2000-04-10 WO PCT/GB2000/001349 patent/WO2000062707A2/en not_active Application Discontinuation
- 2000-04-10 EP EP00919041A patent/EP1168983A2/en not_active Withdrawn
- 2000-04-10 CA CA002370358A patent/CA2370358A1/en not_active Abandoned
- 2000-04-10 AU AU39797/00A patent/AU3979700A/en not_active Abandoned
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AU3979700A (en) | 2000-11-02 |
GB9908638D0 (en) | 1999-06-09 |
WO2000062707A3 (en) | 2001-01-25 |
EP1168983A2 (en) | 2002-01-09 |
WO2000062707A2 (en) | 2000-10-26 |
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