CA2368934A1

CA2368934A1 - Inhalateur doseur de propionate de fluticasone

Inhalateur doseur de propionate de fluticasone Download PDF

Info

Publication number: CA2368934A1
Authority: CA; Canada
Prior art keywords: fluorocarbon; combination; drug formulation; fluticasone propionate; preparation according
Prior art date: 1995-04-14
Legal status : Abandoned

Application number

CA002368934A

Other languages

English (en)

Inventor

Ignatius Loy Britto

Current Assignee

SmithKline Beecham Corp

Original Assignee

Individual

Priority date

1995-04-14

Filing date

1996-04-10

Publication date

1996-10-17

1996-04-10 Application filed by Individual filed Critical Individual

1996-04-10 Priority claimed from CA002217948A external-priority patent/CA2217948C/fr

1996-10-17 Publication of CA2368934A1 publication Critical patent/CA2368934A1/fr

Status Abandoned legal-status Critical Current

Links

WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 title claims abstract description 41
229960000289 fluticasone propionate Drugs 0.000 title claims abstract description 39
229940071648 metered dose inhaler Drugs 0.000 title claims abstract description 9
239000013583 drug formulation Substances 0.000 claims abstract description 47
239000003380 propellant Substances 0.000 claims abstract description 45
229920002313 fluoropolymer Polymers 0.000 claims abstract description 42
NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims abstract description 30
239000012453 solvate Substances 0.000 claims abstract description 23
239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 15
239000013543 active substance Substances 0.000 claims abstract description 13
229920002959 polymer blend Polymers 0.000 claims abstract description 13
239000000825 pharmaceutical preparation Substances 0.000 claims abstract description 3
239000000203 mixture Substances 0.000 claims description 34
239000003814 drug Substances 0.000 claims description 30
229940079593 drug Drugs 0.000 claims description 24
238000002360 preparation method Methods 0.000 claims description 21
239000004812 Fluorinated ethylene propylene Substances 0.000 claims description 17
GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims description 17
229920009441 perflouroethylene propylene Polymers 0.000 claims description 17
238000009472 formulation Methods 0.000 claims description 15
239000004813 Perfluoroalkoxy alkane Substances 0.000 claims description 14
229920011301 perfluoro alkoxyl alkane Polymers 0.000 claims description 14
229920000642 polymer Polymers 0.000 claims description 14
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239000004094 surface-active agent Substances 0.000 claims description 13
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 12
-1 polytetrafluoroethylene Polymers 0.000 claims description 12
229910052782 aluminium Inorganic materials 0.000 claims description 11
229960005018 salmeterol xinafoate Drugs 0.000 claims description 11
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LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical group FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 claims description 8
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YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 claims description 5
229910045601 alloy Inorganic materials 0.000 claims description 5
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IWLBIFVMPLUHLK-UHFFFAOYSA-N azane;formaldehyde Chemical compound N.O=C IWLBIFVMPLUHLK-UHFFFAOYSA-N 0.000 claims description 3
HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 claims description 3
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239000004734 Polyphenylene sulfide Substances 0.000 claims 2
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TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical group FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 claims 1
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LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 10
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