CA2367390A1 - Utilisation de vecteurs adenoviraux dependants d'un assistant, de differents serotypes, permettant une administration repetee des vecteurs - Google Patents
Utilisation de vecteurs adenoviraux dependants d'un assistant, de differents serotypes, permettant une administration repetee des vecteurs Download PDFInfo
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- CA2367390A1 CA2367390A1 CA002367390A CA2367390A CA2367390A1 CA 2367390 A1 CA2367390 A1 CA 2367390A1 CA 002367390 A CA002367390 A CA 002367390A CA 2367390 A CA2367390 A CA 2367390A CA 2367390 A1 CA2367390 A1 CA 2367390A1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/38—Vector systems having a special element relevant for transcription being a stuffer
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Dans un mode de réalisation, l'invention concerne un virus assistant basé sur le sérotype Ad2, destiné à être utilisé dans le système CreloxP permettant la génération de vecteurs Ad ne contenant plus aucune séquence codante pour les protéines Ad. Des hdAd génétiquement identiques ont pu être produits, à l'aide de ce virus assistant et d'un virus assistant basé sur Ad5, se distinguant seulement par les composants de la protéine vif, dérivés du virus assistant. Les vecteurs possèdent des caractéristiques d'expression identiques in vitro, indépendamment du sérotype, et l'utilisation séquentielle de hdAd de différents sérotypes permet de répéter avec succès l'administration du vecteur in vivo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/286,874 | 1999-04-06 | ||
| US09/286,874 US6730507B1 (en) | 1993-06-24 | 1999-04-06 | Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration |
| PCT/US2000/009149 WO2000060106A1 (fr) | 1999-04-06 | 2000-04-06 | Utilisation de vecteurs adenoviraux dependants d'un assistant, de differents serotypes, permettant une administration repetee des vecteurs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2367390A1 true CA2367390A1 (fr) | 2000-10-12 |
Family
ID=23100547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002367390A Abandoned CA2367390A1 (fr) | 1999-04-06 | 2000-04-06 | Utilisation de vecteurs adenoviraux dependants d'un assistant, de differents serotypes, permettant une administration repetee des vecteurs |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1165817A1 (fr) |
| JP (1) | JP2003519464A (fr) |
| AU (1) | AU768836B2 (fr) |
| CA (1) | CA2367390A1 (fr) |
| WO (1) | WO2000060106A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7144880B2 (en) * | 1999-04-30 | 2006-12-05 | Regents Of The University Of Michigan | Compositions relating to novel compounds and targets thereof |
| DE10006886A1 (de) * | 2000-02-16 | 2001-08-23 | Hepavec Ag Fuer Gentherapie | Nichthumaner helferabhängiger Virusvektor |
| US7754201B2 (en) * | 2000-06-02 | 2010-07-13 | GenPhar, Inc | Method of vaccination through serotype rotation |
| AU2003288273A1 (en) | 2002-10-23 | 2004-05-13 | Crucell Holland B.V. | New settings for recombinant adenoviral-based vaccines |
| US20080153083A1 (en) | 2003-10-23 | 2008-06-26 | Crucell Holland B.V. | Settings for recombinant adenoviral-based vaccines |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5919676A (en) * | 1993-06-24 | 1999-07-06 | Advec, Inc. | Adenoviral vector system comprising Cre-loxP recombination |
| US6080569A (en) * | 1993-06-24 | 2000-06-27 | Merck & Co., Inc. | Adenovirus vectors generated from helper viruses and helper-dependent vectors |
| US5849561A (en) * | 1997-05-22 | 1998-12-15 | Cornell Research Foundation, Inc. | Method for the production of non-group C adenoviral vectors |
-
2000
- 2000-04-06 EP EP00920182A patent/EP1165817A1/fr not_active Withdrawn
- 2000-04-06 CA CA002367390A patent/CA2367390A1/fr not_active Abandoned
- 2000-04-06 WO PCT/US2000/009149 patent/WO2000060106A1/fr not_active Application Discontinuation
- 2000-04-06 AU AU40761/00A patent/AU768836B2/en not_active Ceased
- 2000-04-06 JP JP2000609596A patent/JP2003519464A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000060106A1 (fr) | 2000-10-12 |
| AU768836B2 (en) | 2004-01-08 |
| JP2003519464A (ja) | 2003-06-24 |
| EP1165817A1 (fr) | 2002-01-02 |
| AU4076100A (en) | 2000-10-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |