CA2366928A1 - Positively charged membrane - Google Patents

Positively charged membrane Download PDF

Info

Publication number
CA2366928A1
CA2366928A1 CA002366928A CA2366928A CA2366928A1 CA 2366928 A1 CA2366928 A1 CA 2366928A1 CA 002366928 A CA002366928 A CA 002366928A CA 2366928 A CA2366928 A CA 2366928A CA 2366928 A1 CA2366928 A1 CA 2366928A1
Authority
CA
Canada
Prior art keywords
positively charged
present
provides
porous substrate
membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002366928A
Other languages
French (fr)
Other versions
CA2366928C (en
Inventor
Xiaosong Wu
Chung-Jen Hou
Jayesh Dharia
Peter Konstantin
Yujing Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pall Corp
Original Assignee
Pall Corporation
Xiaosong Wu
Chung-Jen Hou
Jayesh Dharia
Peter Konstantin
Yujing Yang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26819701&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2366928(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pall Corporation, Xiaosong Wu, Chung-Jen Hou, Jayesh Dharia, Peter Konstantin, Yujing Yang filed Critical Pall Corporation
Publication of CA2366928A1 publication Critical patent/CA2366928A1/en
Application granted granted Critical
Publication of CA2366928C publication Critical patent/CA2366928C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0088—Physical treatment with compounds, e.g. swelling, coating or impregnation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/58—Other polymers having nitrogen in the main chain, with or without oxygen or carbon only
    • B01D71/60—Polyamines
    • B01D71/601—Polyethylenimine
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/147—Microfiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/10—Supported membranes; Membrane supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/10—Supported membranes; Membrane supports
    • B01D69/106—Membranes in the pores of a support, e.g. polymerized in the pores or voids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/40—Polymers of unsaturated acids or derivatives thereof, e.g. salts, amides, imides, nitriles, anhydrides, esters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/58—Other polymers having nitrogen in the main chain, with or without oxygen or carbon only
    • B01D71/60—Polyamines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/08—Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/12—Macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J47/00—Ion-exchange processes in general; Apparatus therefor
    • B01J47/12—Ion-exchange processes in general; Apparatus therefor characterised by the use of ion-exchange material in the form of ribbons, filaments, fibres or sheets, e.g. membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1017—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by filtration, e.g. using filters, frits, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange

Abstract

The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane.
The present invention further provides a positively charged microporous membrane comprising porous substrate and a crosslinked coating comprising pendent cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxines, and the like.
CA002366928A 1999-02-25 2000-02-25 Positively charged membrane Expired - Lifetime CA2366928C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12167099P 1999-02-25 1999-02-25
US12166999P 1999-02-25 1999-02-25
US60/121,669 1999-02-25
US60/121,670 1999-02-25
PCT/US2000/004786 WO2000050161A1 (en) 1999-02-25 2000-02-25 Positively charged membrane

Publications (2)

Publication Number Publication Date
CA2366928A1 true CA2366928A1 (en) 2000-08-31
CA2366928C CA2366928C (en) 2009-07-14

Family

ID=26819701

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002366928A Expired - Lifetime CA2366928C (en) 1999-02-25 2000-02-25 Positively charged membrane

Country Status (6)

Country Link
EP (1) EP1163045B2 (en)
JP (1) JP4271871B2 (en)
AU (1) AU3706700A (en)
CA (1) CA2366928C (en)
DE (3) DE60035627T2 (en)
WO (1) WO2000050161A1 (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003535589A (en) * 2000-06-02 2003-12-02 パル・コーポレーション Processing of plasmid-containing solutions
DE10228148B4 (en) * 2002-06-24 2006-08-24 Saehan Industries Inc. Selective membrane with high fouling resistance
ATE548097T1 (en) * 2002-09-03 2012-03-15 Whatman Ltd POROUS COMPOSITE MEMBRANE AND PRODUCTION METHOD THEREOF
EP1617936B1 (en) 2003-02-19 2009-11-18 Natrix Separations Inc. Composite materials comprising supported porous gels
EP2821135A1 (en) 2004-02-05 2015-01-07 EMD Millipore Corporation Porous adsorptive or chromatographic media
US7285219B2 (en) 2004-08-10 2007-10-23 Prime Separations, Inc. Chromatographic separation member and method
DE102006008701A1 (en) * 2006-02-23 2007-08-30 Qiagen Gmbh Procedure for transferring biomolecules into a cell, comprises preparing a complex from biomolecule and polymer, and transferring the biomolecule into a cell by contacting the cell with the complex
US9433922B2 (en) 2007-08-14 2016-09-06 Emd Millipore Corporation Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
US20090130738A1 (en) * 2007-11-19 2009-05-21 Mikhail Kozlov Media for membrane ion exchange chromatography
KR102178191B1 (en) 2008-09-02 2020-11-13 머크 밀리포어 리미티드 Chromatography membranes, devices containing them, and methods of use thereof
DE102009057993A1 (en) 2009-06-13 2011-01-20 Sartorius Stedim Biotech Gmbh Grafted polymer polysaccharide matrix, process for its preparation and use
US8011517B2 (en) * 2009-11-24 2011-09-06 International Business Machines Corporation Composite membranes with performance enhancing layers
WO2011081869A2 (en) * 2009-12-14 2011-07-07 Betty Wu Method and materials for separating nucleic acid materials
CN102844662B (en) 2010-03-03 2015-04-29 3M创新有限公司 Ligand functionalized polymers
KR101619865B1 (en) * 2010-07-30 2016-05-11 이엠디 밀리포어 코포레이션 Chromatography media
JP6130791B2 (en) * 2011-01-04 2017-05-17 ザ リサーチ ファウンデーション オブ ザ ステイト ユニヴァーシティ オブ ニューヨーク Functionalization of nanofiber microfiltration membranes for water purification
JP2012211110A (en) * 2011-03-31 2012-11-01 Asahi Kasei Medical Co Ltd Porous adsorption film
AU2012255721A1 (en) 2011-05-17 2014-01-09 Natrix Separations Inc. Layered tubular membranes for chromatography, and methods of use thereof
US9302228B2 (en) 2014-02-28 2016-04-05 Pall Corporation Charged porous polymeric membrane with high void volume
US9561473B2 (en) 2014-02-28 2017-02-07 Pall Corporation Charged hollow fiber membrane having hexagonal voids
US9737860B2 (en) 2014-02-28 2017-08-22 Pall Corporation Hollow fiber membrane having hexagonal voids
US20170072368A1 (en) * 2014-03-11 2017-03-16 Toray Industries, Inc. Porous membrane and water purifier
US9962662B2 (en) 2014-06-30 2018-05-08 Pall Corporation Fluorinated polymer and use thereof in the preparation of hydrophilic membranes (vi)
US9394407B2 (en) 2014-06-30 2016-07-19 Pall Corporation Hydrophilic block copolymers and membranes prepared therefrom (I)
US9718924B2 (en) 2014-06-30 2017-08-01 Pall Corporation Hydrophilic block copolymers and membranes prepared therefrom (II)
US9260569B2 (en) * 2014-06-30 2016-02-16 Pall Corporation Hydrophilic block copolymers and method of preparation thereof (III)
EP3115099B1 (en) 2015-07-07 2019-09-04 I3 Membrane GmbH Method for electrofiltration and electro sorption by means of a metal coated polymermembrane and apparatus therefor
JP6448498B2 (en) 2015-08-04 2019-01-09 日本ゴア株式会社 Precision filter for circuit board manufacturing process liquid
CN114839374A (en) 2017-03-28 2022-08-02 相达生物科技国际有限公司 Method for accurate diagnosis of disease-targeted biomarkers in liquid biopsies
CN110891664B (en) 2017-06-01 2022-05-17 相达生物科技美国有限公司 Phase separation behavior modifier for aqueous two-phase separation in porous materials
US11609232B2 (en) 2017-09-01 2023-03-21 Phase Diagnostics, Inc. Method and device of using aqueous two-phase systems (ATPS) for enhancing diagnostics for sexually transmitted infections
JP7370987B2 (en) * 2018-01-19 2023-10-30 フェーズ サイエンティフィック インターナショナル リミテッド Methods for isolating and purifying nucleic acids using solid-liquid phase systems
US11479765B2 (en) 2018-01-19 2022-10-25 Phase Scientific International, Ltd. Method of isolating exosomes using encapsulation and aqueous micellar system
US11332796B2 (en) 2018-01-19 2022-05-17 Phase Scientific International, Ltd. Composition and method for concentration and enrichment of nucleic acids
JP7106937B2 (en) * 2018-03-30 2022-07-27 栗田工業株式会社 PARTICLE REMOVAL MEMBRANE, PARTICLE REMOVAL DEVICE, AND PARTICLE REMOVAL METHOD
US10737259B2 (en) * 2018-08-31 2020-08-11 Pall Corporation Salt tolerant anion exchange medium
US20200171442A1 (en) * 2018-11-30 2020-06-04 Entegris, Inc. Hydrophilic filter membrane with pendant hydrophilic groups, and related methods of preparation and use
EP3815763A1 (en) 2019-11-01 2021-05-05 I3 Membrane GmbH Method and apparatus for dc voltage controlled adsorption and desorption on charged membranes
CN111330447B (en) * 2020-02-26 2022-03-15 天津科技大学 Positively charged composite nanofiltration membrane, and preparation method and application thereof
US20230158483A1 (en) * 2020-04-24 2023-05-25 Toyobo Co., Ltd. Cellulose-based ion-exchange membrane, production method for same, exosome purification device, and exosome purification method

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5535910A (en) † 1978-09-06 1980-03-13 Teijin Ltd Permselectivity composite membrane and preparation thereof
JPS5695304A (en) † 1979-12-28 1981-08-01 Teijin Ltd Perm selective composite membrane and its production
US4473474A (en) * 1980-10-27 1984-09-25 Amf Inc. Charge modified microporous membrane, process for charge modifying said membrane and process for filtration of fluid
US4601828A (en) * 1983-02-07 1986-07-22 Yale University Transfer of macromolecules from a chromatographic substrate to an immobilizing matrix
US4915839A (en) † 1984-03-15 1990-04-10 Cuno, Incorporated Process for surface modifying a microporous membrane
US5114585A (en) † 1988-03-01 1992-05-19 Gelman Sciences, Inc. Charged porous filter
US5151189A (en) * 1990-09-17 1992-09-29 Gelman Sciences, Inc. Cationic charge modified microporous membrane
DE4207171C2 (en) † 1991-03-06 1994-05-19 Sartorius Gmbh Process for the surface modification of moldings, grafted moldings produced therewith and their use for adsorptive material separation
US5354472A (en) † 1991-12-04 1994-10-11 Cobe Cardiovascular, Inc. Anion exchange materials comprised of derivatized cellulose-polyester composites

Also Published As

Publication number Publication date
JP2002537106A (en) 2002-11-05
AU3706700A (en) 2000-09-14
DE60043597D1 (en) 2010-02-04
DE60035627T2 (en) 2008-04-10
DE60035627D1 (en) 2007-08-30
JP4271871B2 (en) 2009-06-03
DE60011584D1 (en) 2004-07-22
EP1163045B1 (en) 2004-06-16
DE60011584T3 (en) 2008-03-06
CA2366928C (en) 2009-07-14
EP1163045B2 (en) 2007-08-22
DE60011584T2 (en) 2005-07-07
WO2000050161A1 (en) 2000-08-31
EP1163045A1 (en) 2001-12-19

Similar Documents

Publication Publication Date Title
CA2366928A1 (en) Positively charged membrane
Alpert High-performance hydrophobic-interaction chromatography of proteins on a series of poly (alkyl aspart-amide)-silicas
US6780327B1 (en) Positively charged membrane
CA2349948A1 (en) A chromatography method and a column material useful in said method
WO2000054046A3 (en) Universal protein array system
HK1040401A1 (en) Isolated nucleic acid molecules which encode t cell inducible factors (tifs), the proteins encoded, and uses thereof
Bhushan et al. Thin-layer chromatographic separation of enantiomeric dansylamino acids using a macrocyclic antibiotic as a chiral selector
CA2295999A1 (en) Nik proteins, nucleic acids and methods
JP2002537106A5 (en)
WO2003020932A1 (en) Novel secretory proteins and dna thereof
Li et al. Biocompatible polymeric monoliths for protein and peptide separations
AU5062700A (en) Use of a composite polymer-coated sorbent for separation, purification, desalting and concentration of biopolymers
CA2224404A1 (en) Cell volume-regulated human kinase h-sgk
WO2002024912A3 (en) Isolated nucleic acid molecules which encode a soluble il-tif/il-22 receptor or binding protein which binds to il-tif/il-22, and uses thereof
WO1984004309A1 (en) Process in the purification of biologically active substances
JP2020501879A (en) Amphoteric dissociation type ion exchange medium, method of use and method of calibrating separation capacity
JPS6345558A (en) Antiphase filler
WO1996007739A3 (en) Interleukin-1 type 3 receptors
CA2294566A1 (en) Ikk-.alpha. proteins, nucleic acids and methods
ZA9710163B (en) Novel carboxylesterase nucleic acid molecules, proteins and uses thereof.
AU5366099A (en) Nucleic acid molecules encoding inclusion membrane protein of (chlamydia)
WO2001034292A3 (en) Macroporous media for biological application prepared by freeze drying
CA2316113A1 (en) Method for nucleic acid purification using iodine
JP2002541155A5 (en)
EP0677115A4 (en) Tia-1 binding proteins and isolated complementary dna encoding the same.

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20200225