CA2364002A1 - Peptides immunogenes derives de mage-3 presentes par le complexe majeur d'histocompatibilte (mch) de categorie ii et utilisations associees - Google Patents
Peptides immunogenes derives de mage-3 presentes par le complexe majeur d'histocompatibilte (mch) de categorie ii et utilisations associees Download PDFInfo
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- CA2364002A1 CA2364002A1 CA002364002A CA2364002A CA2364002A1 CA 2364002 A1 CA2364002 A1 CA 2364002A1 CA 002364002 A CA002364002 A CA 002364002A CA 2364002 A CA2364002 A CA 2364002A CA 2364002 A1 CA2364002 A1 CA 2364002A1
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- cells
- peptides
- mage
- hla
- peptide
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- APEBUJBRGCMMHP-HJWJTTGWSA-N Val-Ile-Phe Chemical compound CC(C)[C@H](N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 APEBUJBRGCMMHP-HJWJTTGWSA-N 0.000 description 1
- XTDDIVQWDXMRJL-IHRRRGAJSA-N Val-Leu-His Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)O)NC(=O)[C@H](C(C)C)N XTDDIVQWDXMRJL-IHRRRGAJSA-N 0.000 description 1
- VPGCVZRRBYOGCD-AVGNSLFASA-N Val-Lys-Val Chemical compound CC(C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(O)=O VPGCVZRRBYOGCD-AVGNSLFASA-N 0.000 description 1
- CKTMJBPRVQWPHU-JSGCOSHPSA-N Val-Phe-Gly Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)O)N CKTMJBPRVQWPHU-JSGCOSHPSA-N 0.000 description 1
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- 108010047495 alanylglycine Proteins 0.000 description 1
- UPEZCKBFRMILAV-UHFFFAOYSA-N alpha-Ecdysone Natural products C1C(O)C(O)CC2(C)C(CCC3(C(C(C(O)CCC(C)(C)O)C)CCC33O)C)C3=CC(=O)C21 UPEZCKBFRMILAV-UHFFFAOYSA-N 0.000 description 1
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- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
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- 231100000263 cytotoxicity test Toxicity 0.000 description 1
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- UPEZCKBFRMILAV-JMZLNJERSA-N ecdysone Chemical compound C1[C@@H](O)[C@@H](O)C[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@@H]([C@H](O)CCC(C)(C)O)C)CC[C@]33O)C)C3=CC(=O)[C@@H]21 UPEZCKBFRMILAV-JMZLNJERSA-N 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000006862 enzymatic digestion Effects 0.000 description 1
- 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 description 1
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- 238000006062 fragmentation reaction Methods 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 108010051307 glycyl-glycyl-proline Proteins 0.000 description 1
- 108010020688 glycylhistidine Proteins 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000000185 hemagglutinin Substances 0.000 description 1
- 108010028295 histidylhistidine Proteins 0.000 description 1
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- 230000005847 immunogenicity Effects 0.000 description 1
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- 108010047926 leucyl-lysyl-tyrosine Proteins 0.000 description 1
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- 230000007774 longterm Effects 0.000 description 1
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- 125000004492 methyl ester group Chemical group 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La présente invention concerne des peptides dérivés de la protéine MAGE-3, des compositions pharmaceutiques qui contiennent ces peptides et leurs utilisations dans l'induction de réponse immune contre des tumeurs.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI000396A IT1309584B1 (it) | 1999-02-26 | 1999-02-26 | Peptidi immunogenici derivati da mage-3 presentati da mhc di classeii e loro uso. |
| ITMI99A000396 | 1999-02-26 | ||
| PCT/EP2000/001458 WO2000052045A2 (fr) | 1999-02-26 | 2000-02-23 | Peptides immunogenes derives de mage-3 presentes par le complexe majeur d'histocompatibilte (mch) de categorie ii et utilisations associees |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2364002A1 true CA2364002A1 (fr) | 2000-09-08 |
Family
ID=11382063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002364002A Abandoned CA2364002A1 (fr) | 1999-02-26 | 2000-02-23 | Peptides immunogenes derives de mage-3 presentes par le complexe majeur d'histocompatibilte (mch) de categorie ii et utilisations associees |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1161443A2 (fr) |
| JP (1) | JP2002538166A (fr) |
| AU (1) | AU2913400A (fr) |
| CA (1) | CA2364002A1 (fr) |
| IT (1) | IT1309584B1 (fr) |
| WO (1) | WO2000052045A2 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001074847A2 (fr) * | 2000-03-30 | 2001-10-11 | The Government Of The United States Of America Represented By The Secretary, Department Of Health And Human Services | Epitope de lymphocyte t de mage-12 et acides nucleiques, vecteurs et cellules correspondants, compositions et procedes induisant une reaction immunitaire a un cancer |
| WO2002094994A2 (fr) | 2001-05-18 | 2002-11-28 | Mayo Foundation For Medical Education And Research | Polypeptides chimeres specifiques d'antigene activant des lymphocytes t |
| US20060222656A1 (en) | 2005-04-01 | 2006-10-05 | University Of Maryland, Baltimore | MAGE-A3/HPV 16 peptide vaccines for head and neck cancer |
| US7049413B2 (en) | 2001-05-18 | 2006-05-23 | Ludwig Institute For Cancer Research | MAGE-A3 peptides presented by HLA class II molecules |
| FR2837837B1 (fr) * | 2002-03-28 | 2006-09-29 | Roussy Inst Gustave | Epitopes peptidiques communs a des antigenes d'une meme famille multigenique |
| EP1715343B1 (fr) * | 2005-04-20 | 2009-12-09 | F. Hoffmann-La Roche Ag | Méthode d'identification des épitopes en rapport avec l'immunogénicité des produits bio-pharmaceutiques |
| WO2008053573A1 (fr) * | 2006-10-30 | 2008-05-08 | National University Corporation Hokkaido University | Remède pour néoplasme malin |
| JP6313478B2 (ja) * | 2014-05-30 | 2018-04-18 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | Ｍａｇｅ−ａ３ペプチド標的アプタマー及びその使用 |
| GB201804468D0 (en) * | 2018-03-21 | 2018-05-02 | Valo Therapeutics Oy | PeptiCRAd Cancer Therapy |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5662907A (en) * | 1992-08-07 | 1997-09-02 | Cytel Corporation | Induction of anti-tumor cytotoxic T lymphocytes in humans using synthetic peptide epitopes |
| KR960700739A (ko) * | 1993-03-05 | 1996-02-24 | 카린 이스텀 | Hla-a2. 1 결합 펩티드 및 그의 용도(hla-a2. 1 binding peptides and their uses) |
| WO1998033888A1 (fr) * | 1997-01-31 | 1998-08-06 | Epimmune, Inc. | Cellules a peptides ou a antigenes charges de peptides |
| WO1999003972A1 (fr) * | 1997-07-15 | 1999-01-28 | Takara Shuzo Co., Ltd. | Lymphocytes t cytotoxiques |
| US5965535A (en) * | 1997-09-12 | 1999-10-12 | Ludwig Institute For Cancer Research | Mage-3 peptides presented by HLA class II molecules |
| CA2323632A1 (fr) * | 1998-03-13 | 1999-09-16 | Epimmune Inc. | Peptides de liaison de hla et leurs applications |
-
1999
- 1999-02-26 IT IT1999MI000396A patent/IT1309584B1/it active
-
2000
- 2000-02-23 EP EP00907601A patent/EP1161443A2/fr not_active Withdrawn
- 2000-02-23 WO PCT/EP2000/001458 patent/WO2000052045A2/fr not_active Application Discontinuation
- 2000-02-23 CA CA002364002A patent/CA2364002A1/fr not_active Abandoned
- 2000-02-23 AU AU29134/00A patent/AU2913400A/en not_active Abandoned
- 2000-02-23 JP JP2000602269A patent/JP2002538166A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IT1309584B1 (it) | 2002-01-24 |
| ITMI990396A1 (it) | 2000-08-26 |
| WO2000052045A3 (fr) | 2001-01-04 |
| EP1161443A2 (fr) | 2001-12-12 |
| WO2000052045A2 (fr) | 2000-09-08 |
| JP2002538166A (ja) | 2002-11-12 |
| AU2913400A (en) | 2000-09-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |