CA2356966A1 - Amidomalonamides et leurs utilisations comme inhibiteurs des metalloproteinases matricielles - Google Patents

Amidomalonamides et leurs utilisations comme inhibiteurs des metalloproteinases matricielles Download PDF

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Publication number
CA2356966A1
CA2356966A1 CA002356966A CA2356966A CA2356966A1 CA 2356966 A1 CA2356966 A1 CA 2356966A1 CA 002356966 A CA002356966 A CA 002356966A CA 2356966 A CA2356966 A CA 2356966A CA 2356966 A1 CA2356966 A1 CA 2356966A1
Authority
CA
Canada
Prior art keywords
compound
group
hydrogen
alkyl
malonamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002356966A
Other languages
English (en)
Inventor
Michael J. Janusz
Alan Warshawsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2356966A1 publication Critical patent/CA2356966A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention porte sur de nouvelles aminomalonamides de formule (1) et des préparations pharmaceutiques les contenant s'utilisant pour inhiber les métallo-protéinases matricielles.
CA002356966A 1998-12-31 1999-11-30 Amidomalonamides et leurs utilisations comme inhibiteurs des metalloproteinases matricielles Abandoned CA2356966A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22445998A 1998-12-31 1998-12-31
US09/224,459 1998-12-31
PCT/US1999/028338 WO2000040552A1 (fr) 1998-12-31 1999-11-30 Amidomalonamides et leurs utilisations comme inhibiteurs des metalloproteinases matricielles

Publications (1)

Publication Number Publication Date
CA2356966A1 true CA2356966A1 (fr) 2000-07-13

Family

ID=22840789

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002356966A Abandoned CA2356966A1 (fr) 1998-12-31 1999-11-30 Amidomalonamides et leurs utilisations comme inhibiteurs des metalloproteinases matricielles

Country Status (10)

Country Link
EP (1) EP1140818B1 (fr)
JP (1) JP2002534410A (fr)
AR (1) AR022169A1 (fr)
AT (1) ATE249429T1 (fr)
AU (1) AU1836800A (fr)
CA (1) CA2356966A1 (fr)
DE (1) DE69911250T2 (fr)
ES (1) ES2203226T3 (fr)
TW (1) TW533192B (fr)
WO (1) WO2000040552A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1481960A4 (fr) 2002-02-04 2005-04-06 Kaneka Corp Procede d'obtention d'acides 2-halogeno-carboxyliques optiquement actifs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9323165D0 (en) * 1993-11-10 1994-01-05 Chiros Ltd Compounds
CA2217859A1 (fr) * 1995-05-10 1996-11-14 David Alan Owen Composes de peptidyle inhibant la liberation de metalloproteinases et de tnf, et leurs utilisations therapeutiques

Also Published As

Publication number Publication date
DE69911250T2 (de) 2004-07-01
EP1140818A1 (fr) 2001-10-10
AR022169A1 (es) 2002-09-04
EP1140818B1 (fr) 2003-09-10
WO2000040552A1 (fr) 2000-07-13
AU1836800A (en) 2000-07-24
JP2002534410A (ja) 2002-10-15
DE69911250D1 (de) 2003-10-16
ATE249429T1 (de) 2003-09-15
ES2203226T3 (es) 2004-04-01
TW533192B (en) 2003-05-21

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued