CA2351690A1 - Inhibiteurs heterocycliques de thio-uree des virus de l'herpes contenant du carboxamide et un groupe phenylenediamine substitue - Google Patents
Inhibiteurs heterocycliques de thio-uree des virus de l'herpes contenant du carboxamide et un groupe phenylenediamine substitue Download PDFInfo
- Publication number
- CA2351690A1 CA2351690A1 CA002351690A CA2351690A CA2351690A1 CA 2351690 A1 CA2351690 A1 CA 2351690A1 CA 002351690 A CA002351690 A CA 002351690A CA 2351690 A CA2351690 A CA 2351690A CA 2351690 A1 CA2351690 A1 CA 2351690A1
- Authority
- CA
- Canada
- Prior art keywords
- phenyl
- thioureido
- chloro
- carbon atoms
- amide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Abstract
L'invention concerne des composés de formule I, dans laquelle: R1-R5 sont choisis indépendamment entre hydrogène et des substituants de celui-ci; R9-R12 représentent indépendamment hydrogène ou des substituants de celui-ci, à condition qu'au moins un parmi R9-R12 ne désigne pas hydrogène; G symbolise un hétéroaryle monocyclique; X représente une liaison,NH, alkyle avec 1 à 6 atomes de carbone, alkényle avec 1 à 6 atomes de carbone, alkoxy avec 1 à 6 atomes de carbone, thioalkyle avec 1 à 6 atomes de carbone, alkylamino avec 1 à 6 atomes de carbone, ou (CH)J; J désigne alkyle avec 1 à 6 atomes de carbone, cycloalkyle avec 3 à 7 atomes de carbone, phényle, ou benzyle. Ces composés sont utiles pour traiter les maladies liés aux virus de l'herpès, notamment les maladies des inclusions cytomégaliques humaines, l'herpès simplex virus, le virus d'Epstein-Barr, le virus varicelle-zona, les virus de l'herpès humain types 6 et 7, et le virus de l'herpès de Kaposi.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20816498A | 1998-12-09 | 1998-12-09 | |
US09/208,164 | 1998-12-09 | ||
PCT/US1999/028916 WO2000034261A2 (fr) | 1998-12-09 | 1999-12-06 | Inhibiteurs heterocycliques de thio-uree des virus de l'herpes contenant du carboxamide et un groupe phenylenediamine substitue |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2351690A1 true CA2351690A1 (fr) | 2000-06-15 |
Family
ID=22773466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002351690A Abandoned CA2351690A1 (fr) | 1998-12-09 | 1999-12-06 | Inhibiteurs heterocycliques de thio-uree des virus de l'herpes contenant du carboxamide et un groupe phenylenediamine substitue |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP1144399A3 (fr) |
JP (1) | JP2002533301A (fr) |
KR (1) | KR20010086091A (fr) |
CN (1) | CN1367785A (fr) |
AU (1) | AU2353900A (fr) |
BR (1) | BR9916043A (fr) |
CA (1) | CA2351690A1 (fr) |
CZ (1) | CZ20012063A3 (fr) |
EA (1) | EA200100639A1 (fr) |
HU (1) | HUP0203405A2 (fr) |
IL (1) | IL143263A0 (fr) |
NO (1) | NO20012835L (fr) |
WO (1) | WO2000034261A2 (fr) |
ZA (1) | ZA200104322B (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
WO2001064642A2 (fr) | 2000-02-29 | 2001-09-07 | Cor Therapeutics, Inc. | Benzamides et inhibiteurs connexes du facteur xa |
NZ544674A (en) * | 2003-07-10 | 2009-03-31 | Achillion Pharmaceuticals Inc | Substituted arylthiourea derivatives useful as inhibitors of viral replication |
DE102004015007A1 (de) * | 2004-03-26 | 2005-10-13 | Bayer Healthcare Ag | Substituierte Imidazole |
TW200600492A (en) | 2004-05-18 | 2006-01-01 | Achillion Pharmaceuticals Inc | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
DE102005008183A1 (de) | 2005-02-23 | 2006-08-31 | Bayer Healthcare Ag | Heterocyclylamid-substituierte Imidazole |
ES2382055T3 (es) | 2006-11-02 | 2012-06-04 | Millennium Pharmaceuticals, Inc. | Métodos para sintetizar sales farmacéuticas de un inhibidor del factor Xa |
WO2014070979A1 (fr) * | 2012-11-03 | 2014-05-08 | Boehringer Ingelheim International Gmbh | Inhibiteurs de cytomégalovirus |
EP2914591B1 (fr) * | 2012-11-03 | 2017-10-11 | Boehringer Ingelheim International GmbH | Inhibiteurs de cytomégalovirus |
CN112807294B (zh) * | 2019-11-18 | 2023-09-05 | 武汉大学 | 一种酰基硫脲类化合物在制备治疗或预防单纯疱疹病毒i型感染药物中的应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69830751T2 (de) * | 1997-04-10 | 2006-05-18 | Pharmacia & Upjohn Co. Llc, Kalamazoo | Polyaromatische Verbindungen zur Behandlung von Herpes-Infektionen |
-
1999
- 1999-12-06 CN CN99815998A patent/CN1367785A/zh active Pending
- 1999-12-06 EP EP99967213A patent/EP1144399A3/fr not_active Withdrawn
- 1999-12-06 EA EA200100639A patent/EA200100639A1/ru unknown
- 1999-12-06 KR KR1020017007117A patent/KR20010086091A/ko not_active Application Discontinuation
- 1999-12-06 HU HU0203405A patent/HUP0203405A2/hu unknown
- 1999-12-06 BR BR9916043-9A patent/BR9916043A/pt not_active Application Discontinuation
- 1999-12-06 AU AU23539/00A patent/AU2353900A/en not_active Abandoned
- 1999-12-06 WO PCT/US1999/028916 patent/WO2000034261A2/fr not_active Application Discontinuation
- 1999-12-06 CA CA002351690A patent/CA2351690A1/fr not_active Abandoned
- 1999-12-06 JP JP2000586708A patent/JP2002533301A/ja active Pending
- 1999-12-06 IL IL14326399A patent/IL143263A0/xx unknown
- 1999-12-06 CZ CZ20012063A patent/CZ20012063A3/cs unknown
-
2001
- 2001-05-25 ZA ZA200104322A patent/ZA200104322B/en unknown
- 2001-06-08 NO NO20012835A patent/NO20012835L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1144399A2 (fr) | 2001-10-17 |
WO2000034261A3 (fr) | 2002-01-31 |
JP2002533301A (ja) | 2002-10-08 |
EA200100639A1 (ru) | 2002-06-27 |
NO20012835L (no) | 2001-07-19 |
ZA200104322B (en) | 2002-10-25 |
CN1367785A (zh) | 2002-09-04 |
WO2000034261A2 (fr) | 2000-06-15 |
BR9916043A (pt) | 2001-12-04 |
NO20012835D0 (no) | 2001-06-08 |
CZ20012063A3 (cs) | 2001-10-17 |
IL143263A0 (en) | 2002-04-21 |
HUP0203405A2 (hu) | 2003-02-28 |
KR20010086091A (ko) | 2001-09-07 |
AU2353900A (en) | 2000-06-26 |
EP1144399A3 (fr) | 2002-09-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |