CA2350165A1 - Nouvelle serine protease bssp6 - Google Patents
Nouvelle serine protease bssp6 Download PDFInfo
- Publication number
- CA2350165A1 CA2350165A1 CA002350165A CA2350165A CA2350165A1 CA 2350165 A1 CA2350165 A1 CA 2350165A1 CA 002350165 A CA002350165 A CA 002350165A CA 2350165 A CA2350165 A CA 2350165A CA 2350165 A1 CA2350165 A1 CA 2350165A1
- Authority
- CA
- Canada
- Prior art keywords
- protein
- seq
- nucleotide sequence
- amino acids
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101000964562 Homo sapiens Zinc finger FYVE domain-containing protein 9 Proteins 0.000 title 1
- 102100040801 Zinc finger FYVE domain-containing protein 9 Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 claims abstract 63
- 102000004169 proteins and genes Human genes 0.000 claims abstract 60
- 150000001413 amino acids Chemical class 0.000 claims abstract 57
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 51
- 238000000034 method Methods 0.000 claims abstract 10
- 238000007792 addition Methods 0.000 claims abstract 9
- 238000012217 deletion Methods 0.000 claims abstract 9
- 230000037430 deletion Effects 0.000 claims abstract 9
- 238000006467 substitution reaction Methods 0.000 claims abstract 9
- 230000014509 gene expression Effects 0.000 claims abstract 4
- 230000009261 transgenic effect Effects 0.000 claims abstract 4
- 239000002773 nucleotide Substances 0.000 claims 60
- 125000003729 nucleotide group Chemical group 0.000 claims 60
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 15
- 239000012634 fragment Substances 0.000 claims 14
- 230000000295 complement effect Effects 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 8
- 241001465754 Metazoa Species 0.000 claims 5
- 239000003550 marker Substances 0.000 claims 5
- 238000003745 diagnosis Methods 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 3
- 210000002307 prostate Anatomy 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 210000000628 antibody-producing cell Anatomy 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 208000025698 brain inflammatory disease Diseases 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 230000001900 immune effect Effects 0.000 claims 1
- 208000000509 infertility Diseases 0.000 claims 1
- 230000036512 infertility Effects 0.000 claims 1
- 208000021267 infertility disease Diseases 0.000 claims 1
- 238000011813 knockout mouse model Methods 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 210000002826 placenta Anatomy 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 201000004240 prostatic hypertrophy Diseases 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 210000000582 semen Anatomy 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 claims 1
- 210000001550 testis Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La présente invention concerne des protéines comprenant les séquences d'acides aminés représentées par les SEQ ID NOS: 2, 4 et 6 et des protéines dérivées de ces protéines par suppression, substitution ou addition d'un ou de plusieurs acides aminés dans ces séquences d'acides aminés; des séquences de base les codant; un animal transgénique non humain ayant un niveau d'expression altéré de BSSP6; un anticorps dirigé contre BSSP6; et un procédé de détection de BSSP6 dans un échantillon à l'aide dudit anticorps.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10/347802 | 1998-11-20 | ||
| JP34780298 | 1998-11-20 | ||
| PCT/JP1999/006476 WO2000031257A1 (fr) | 1998-11-20 | 1999-11-19 | Nouvelle serine protease bssp6 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2350165A1 true CA2350165A1 (fr) | 2000-06-02 |
| CA2350165C CA2350165C (fr) | 2011-12-13 |
Family
ID=18392691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2350165A Expired - Fee Related CA2350165C (fr) | 1998-11-20 | 1999-11-19 | Nouvelle serine protease bssp6 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US6921658B1 (fr) |
| EP (1) | EP1132473A4 (fr) |
| AU (1) | AU767187B2 (fr) |
| CA (1) | CA2350165C (fr) |
| WO (1) | WO2000031257A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050053983A1 (en) * | 1998-11-20 | 2005-03-10 | Fuso Pharmaceutical Industries, Ltd. | Novel serine protease BSSP4 |
| ATE451475T1 (de) * | 2003-07-03 | 2009-12-15 | Gentron Llc | Verfahren und systeme zur diagnose von nicht das zentrale nervensystem (zns) betreffenden krankheiten in zns-proben |
| US7777877B2 (en) * | 2006-10-20 | 2010-08-17 | California Institute Of Technology | High efficiency coupling optics for pumping and detection of fluorescence |
| WO2022249382A1 (fr) | 2021-05-27 | 2022-12-01 | 三菱電機株式会社 | Dispositif distributeur, circuit convertisseur, procédé distributeur, dispositif décodeur et circuit convertisseur inverse de flux binaires d'informations, et système optique de communication |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5772996A (en) * | 1990-08-03 | 1998-06-30 | Public Health Laboratory Service Board | Pharmaceutical compositions containing superoxide dismutase from Bacillus Stearothermophilus and Bacillus Caldotenax |
| US5780286A (en) * | 1996-03-14 | 1998-07-14 | Smithkline Beecham Corporation | Arginase II |
| US5840871A (en) | 1997-01-29 | 1998-11-24 | Incyte Pharmaceuticals, Inc. | Prostate-associated kallikrein |
| EP1039801A4 (fr) * | 1997-06-06 | 2003-03-26 | Human Genome Sciences Inc | 207 proteines humaines secretees |
| EP0887414A3 (fr) * | 1997-06-09 | 2002-11-27 | SmithKline Beecham plc | Sérine protéases humaines HGBAB90 |
| US6232456B1 (en) * | 1997-10-06 | 2001-05-15 | Abbott Laboratories | Serine protease reagents and methods useful for detecting and treating diseases of the prostate |
| ATE440951T1 (de) * | 1997-12-17 | 2009-09-15 | Serono Genetics Inst Sa | Verlängerte cdns, die für sekretierte proteine kodieren |
| US6075136A (en) * | 1998-02-17 | 2000-06-13 | Incyte Pharmaceuticals, Inc. | Prostate-associated serine protease |
| GB9806095D0 (en) | 1998-03-20 | 1998-05-20 | Smithkline Beecham Biolog | Novel compounds |
| US6331427B1 (en) | 1999-03-26 | 2001-12-18 | Millennium Pharmaceuticals, Inc. | Protease homologs |
| US6420157B1 (en) | 1999-04-30 | 2002-07-16 | Ortho-Mcneil Pharmaceutical, Inc. | Zymogen activation system |
-
1999
- 1999-11-19 AU AU11842/00A patent/AU767187B2/en not_active Ceased
- 1999-11-19 EP EP99972681A patent/EP1132473A4/fr not_active Withdrawn
- 1999-11-19 CA CA2350165A patent/CA2350165C/fr not_active Expired - Fee Related
- 1999-11-19 US US09/856,320 patent/US6921658B1/en not_active Expired - Fee Related
- 1999-11-19 WO PCT/JP1999/006476 patent/WO2000031257A1/fr active IP Right Grant
-
2005
- 2005-02-14 US US11/055,989 patent/US7282579B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2350165C (fr) | 2011-12-13 |
| US6921658B1 (en) | 2005-07-26 |
| AU1184200A (en) | 2000-06-13 |
| US20050170415A1 (en) | 2005-08-04 |
| WO2000031257A1 (fr) | 2000-06-02 |
| AU767187B2 (en) | 2003-11-06 |
| EP1132473A4 (fr) | 2002-06-12 |
| WO2000031257A9 (fr) | 2001-04-05 |
| US7282579B2 (en) | 2007-10-16 |
| EP1132473A1 (fr) | 2001-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20161121 |