CA2348841A1 - Improved growth stimulant compositions - Google Patents

Improved growth stimulant compositions Download PDF

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Publication number
CA2348841A1
CA2348841A1 CA002348841A CA2348841A CA2348841A1 CA 2348841 A1 CA2348841 A1 CA 2348841A1 CA 002348841 A CA002348841 A CA 002348841A CA 2348841 A CA2348841 A CA 2348841A CA 2348841 A1 CA2348841 A1 CA 2348841A1
Authority
CA
Canada
Prior art keywords
growth stimulant
improved growth
release
stimulant compositions
improved
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002348841A
Other languages
French (fr)
Other versions
CA2348841C (en
Inventor
Chung Shih
Thomas J. Kennedy
Peter James Knight
Daniel S. Robins
Zezhi Jesse Shao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2348841A1 publication Critical patent/CA2348841A1/en
Application granted granted Critical
Publication of CA2348841C publication Critical patent/CA2348841C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Feed For Specific Animals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

An improved weight and growth stimulant for domesticated animals such as cattle, pigs and sheep is comprised of an anabolic agent that is subcutaneously administered in the form of a dual release implant formulation. Increased gains are particularly improved when zeranol is administered in an immediate-release and controlled-release formulation which allows for a one-time dosage injection.
CA002348841A 1998-11-04 1999-11-02 Improved growth stimulant compositions Expired - Lifetime CA2348841C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18594498A 1998-11-04 1998-11-04
US09/185,944 1998-11-04
PCT/US1999/023993 WO2000025743A2 (en) 1998-11-04 1999-11-02 Improved growth stimulant compositions

Publications (2)

Publication Number Publication Date
CA2348841A1 true CA2348841A1 (en) 2000-05-11
CA2348841C CA2348841C (en) 2007-04-17

Family

ID=22683037

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002348841A Expired - Lifetime CA2348841C (en) 1998-11-04 1999-11-02 Improved growth stimulant compositions

Country Status (11)

Country Link
AR (1) AR025133A1 (en)
AU (1) AU777393B2 (en)
BR (2) BRPI9914996B8 (en)
CA (1) CA2348841C (en)
CO (1) CO5140100A1 (en)
CR (1) CR6351A (en)
MY (1) MY134868A (en)
PE (1) PE20001092A1 (en)
TW (1) TWI250027B (en)
WO (1) WO2000025743A2 (en)
ZA (1) ZA200103494B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020131988A1 (en) * 1999-12-16 2002-09-19 Foster Todd P. Pharmaceutical implant containing immediate-release and sustained-release components and method of administration
US6953586B1 (en) * 2000-06-08 2005-10-11 Ivy Animal Health, Inc. Growth promoting pharmaceutical implant
EP4001288A1 (en) 2020-11-19 2022-05-25 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of trenbolone acetate having a definite particle size distribution and a irregular hexagon plates crystal habit
EP4000688A1 (en) 2020-11-19 2022-05-25 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of trenbolone acetate having a definite particle size distribution
ES2948624T3 (en) 2020-11-19 2023-09-14 Fis Fabbrica Italiana Sintetici Spa Improved process for the preparation of trenbolone and/or trenbolone acetate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2573307B1 (en) * 1984-11-22 1988-06-10 Virbac Ctre Rech Biolog EXTENDED RELEASE ANABOLIZING IMPLANTS
US4670249A (en) * 1985-04-12 1987-06-02 International Minerals & Chemical Corp. Growth-promoting compositions
US5219572A (en) * 1989-03-17 1993-06-15 Pitman-Moore, Inc. Controlled release delivery device for macromolecular proteins
US5747060A (en) * 1996-03-26 1998-05-05 Euro-Celtique, S.A. Prolonged local anesthesia with colchicine
US5874098A (en) * 1997-05-28 1999-02-23 Ivy Laboratories, Inc. Pellet implant system

Also Published As

Publication number Publication date
BR9914996A (en) 2001-07-10
WO2000025743A3 (en) 2000-08-24
BRPI9914996B1 (en) 2011-11-01
AU3096700A (en) 2000-05-22
CO5140100A1 (en) 2002-03-22
PE20001092A1 (en) 2000-10-31
ZA200103494B (en) 2002-07-30
MY134868A (en) 2007-12-31
CR6351A (en) 2003-11-20
AR025133A1 (en) 2002-11-13
AU777393B2 (en) 2004-10-14
BRPI9914996A (en) 2001-07-10
WO2000025743A2 (en) 2000-05-11
BRPI9914996B8 (en) 2021-07-06
CA2348841C (en) 2007-04-17
TWI250027B (en) 2006-03-01

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20191104