CA2345710C - Preparation de composes haloaromatiques radiomarques au moyen d'intermediaires a liaison polymere - Google Patents

Preparation de composes haloaromatiques radiomarques au moyen d'intermediaires a liaison polymere Download PDF

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Publication number
CA2345710C
CA2345710C CA002345710A CA2345710A CA2345710C CA 2345710 C CA2345710 C CA 2345710C CA 002345710 A CA002345710 A CA 002345710A CA 2345710 A CA2345710 A CA 2345710A CA 2345710 C CA2345710 C CA 2345710C
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Canada
Prior art keywords
formula
compound
polymer
group
insoluble polymer
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Expired - Lifetime
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CA002345710A
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English (en)
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CA2345710A1 (fr
Inventor
Duncan H. Hunter
Xizhen Zhu
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University of Western Ontario
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University of Western Ontario
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Publication of CA2345710A1 publication Critical patent/CA2345710A1/fr
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Publication of CA2345710C publication Critical patent/CA2345710C/fr
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/42—Introducing metal atoms or metal-containing groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

L'invention concerne, dans un premier aspect, un procédé pour la préparation de composés haloaromatiques radiomarqués. Elle concerne également, dans un deuxième aspect, des composés polymères insolubles précurseurs intermédiaires utilisés dans la préparation des composés haloaromatiques radiomarqués, ainsi que des procédés pour la préparation de composés polymères insolubles précurseurs intermédiaires.
CA002345710A 1997-10-02 1998-10-02 Preparation de composes haloaromatiques radiomarques au moyen d'intermediaires a liaison polymere Expired - Lifetime CA2345710C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6088697P 1997-10-02 1997-10-02
US60/060,886 1997-10-02
PCT/CA1998/000933 WO1999018053A1 (fr) 1997-10-02 1998-10-02 Preparation de composes haloaromatiques radiomarques au moyen d'intermediaires a liaison polymere

Publications (2)

Publication Number Publication Date
CA2345710A1 CA2345710A1 (fr) 1999-04-15
CA2345710C true CA2345710C (fr) 2008-12-30

Family

ID=22032357

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002345710A Expired - Lifetime CA2345710C (fr) 1997-10-02 1998-10-02 Preparation de composes haloaromatiques radiomarques au moyen d'intermediaires a liaison polymere

Country Status (2)

Country Link
CA (1) CA2345710C (fr)
WO (1) WO1999018053A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7273601B2 (en) 2000-07-18 2007-09-25 The University Of Western Ontario Preparation of radiolabelled haloaromatics via polymer-bound intermediates
AU2002258100B2 (en) 2001-03-02 2007-03-01 University Of Western Ontario Polymer precursors of radiolabeled compounds, and methods of making and using the same
AU2003301432B2 (en) * 2002-10-18 2008-11-06 Mcmaster University Methods for purifying radiolabelled compounds
GB0229686D0 (en) * 2002-12-20 2003-01-29 Amersham Plc Solid-phase fluorination of benzothiazoles
JP5265869B2 (ja) * 2003-05-02 2013-08-14 ザ ユニバーシティー オブ ウェスタン オンタリオ 放射性医薬化合物の合成に有用な補欠分子族
EP1571150A1 (fr) * 2004-03-02 2005-09-07 Aventis Pharma Deutschland GmbH Procédé pour la prparation des inhibiteurs de tryptase
GB0410448D0 (en) * 2004-05-11 2004-06-16 Hammersmith Imanet Ltd Purification methods
EP2474526A3 (fr) * 2006-12-26 2012-07-25 Lantheus Medical Imaging, Inc. Ligands pour l'imagerie de l'innervation cardiaque
BR122020018194B1 (pt) 2010-05-11 2021-07-27 Lantheus Medical Imaging, Inc. Composições e métodos de síntese de agentes de imagiologia
EP2891657A1 (fr) 2014-01-07 2015-07-08 Centre National de la Recherche Scientifique (CNRS) Réactifs organostannane supportés par un liquide ionique pour la fabrication de composés radiopharmaceutiques
EP3131877B1 (fr) 2014-04-17 2023-07-19 Immunomet Therapeutics Inc. Composés à base de biguanide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565185A (en) * 1994-07-20 1996-10-15 Merck Frosst Canada, Inc. Process for the preparation of radiolabeled meta-halobenzylguanidine

Also Published As

Publication number Publication date
WO1999018053A1 (fr) 1999-04-15
CA2345710A1 (fr) 1999-04-15

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