CA2344093A1 - Detection of antidepressant induced mania - Google Patents
Detection of antidepressant induced mania Download PDFInfo
- Publication number
- CA2344093A1 CA2344093A1 CA002344093A CA2344093A CA2344093A1 CA 2344093 A1 CA2344093 A1 CA 2344093A1 CA 002344093 A CA002344093 A CA 002344093A CA 2344093 A CA2344093 A CA 2344093A CA 2344093 A1 CA2344093 A1 CA 2344093A1
- Authority
- CA
- Canada
- Prior art keywords
- patient
- antidepressant
- sample
- nucleic acids
- determining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
A method of assessing the susceptibility of a patient to antidepressant -induced mania is described.
Claims (10)
1. A method of determining the susceptibility of a patient to antidepressant-induced mania comprising:
(a) obtaining a sample from the patient; and (b) testing the sample for the presence of the s variant of the SHTT~PR
polymorphism in the 5HTT gene, wherein the presence of the s variant indicates that the patient is more susceptible to antidepressant-induced mania.
(a) obtaining a sample from the patient; and (b) testing the sample for the presence of the s variant of the SHTT~PR
polymorphism in the 5HTT gene, wherein the presence of the s variant indicates that the patient is more susceptible to antidepressant-induced mania.
2. A method according to claim 1 wherein the patient has Bipolar Disorder.
3. A method according to claim 1 or 2 wherein the patient is treated with an antidepressant.
4. A method according to claims 3 wherein the antidepressant a pro-serotonergic agent.
5. A method according to claim 4 wherein the pro-serotonergic agent is clomipramine, fluvoxamine, fluoxetine, paroxetine, sertraline, citalopram, imipramine, nefazodone, vanlafaxine or moclobemide.
6. A method according to any one of claims 1 to 5 wherein the sample is blood.
7. A method according to any one of claims 1 to 6 wherein step (b) comprises (i) extracting nucleic acids from the sample; (ii) amplifying the extracted nucleic acids using polymerase chain reaction (PCR);
(iii) performing electrophoresis of the PCR products; and (iv) determining the presence of the polymorphism.
(iii) performing electrophoresis of the PCR products; and (iv) determining the presence of the polymorphism.
8. A kit for determining the susceptibility of a patient to antidepressant-induced mania comprising (i) reagents for conducting a method according to any one of claims 1 to 7 and (ii) instructions for its use.
9. A kit according to claim 8 wherein said reagents comprise nucleic acid primers for amplifying nucleic acids in a polymerase chain reaction.
10. A kit according to claim 8 wherein the reagents comprise nucleic acid primers for amplifying nucleic acids in a polymerase chain reaction, DNA polymerase, dATP, dTTP, dCTP, dGTP and buffers.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26891801P | 2001-02-16 | 2001-02-16 | |
| US60/268,918 | 2001-02-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2344093A1 true CA2344093A1 (en) | 2002-08-16 |
| CA2344093C CA2344093C (en) | 2012-11-13 |
Family
ID=23025066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2344093 Expired - Fee Related CA2344093C (en) | 2001-02-16 | 2001-04-27 | Detection of antidepressant induced mania |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2344093C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005006971A2 (en) * | 2003-07-11 | 2005-01-27 | Wisconsin Alumni Research Foundation | Method for assessing behavioral predisposition |
-
2001
- 2001-04-27 CA CA 2344093 patent/CA2344093C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005006971A2 (en) * | 2003-07-11 | 2005-01-27 | Wisconsin Alumni Research Foundation | Method for assessing behavioral predisposition |
| WO2005006971A3 (en) * | 2003-07-11 | 2005-07-07 | Wisconsin Alumni Res Found | Method for assessing behavioral predisposition |
| US7972779B2 (en) | 2003-07-11 | 2011-07-05 | Wisconsin Alumni Research Foundation | Method for assessing predisposition to depression |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2344093C (en) | 2012-11-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20200831 |