CA2343324A1 - Produits de recombinaison polynucleotidiques et leurs utilisations - Google Patents

Produits de recombinaison polynucleotidiques et leurs utilisations Download PDF

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Publication number
CA2343324A1
CA2343324A1 CA002343324A CA2343324A CA2343324A1 CA 2343324 A1 CA2343324 A1 CA 2343324A1 CA 002343324 A CA002343324 A CA 002343324A CA 2343324 A CA2343324 A CA 2343324A CA 2343324 A1 CA2343324 A1 CA 2343324A1
Authority
CA
Canada
Prior art keywords
vector
promoter
hre
cells
polynucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002343324A
Other languages
English (en)
Inventor
Katie Mary Binley
Stuart Naylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford Biomedica UK Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB1998/002885 external-priority patent/WO1999015684A2/fr
Priority claimed from GBGB9901906.9A external-priority patent/GB9901906D0/en
Priority claimed from GBGB9903538.8A external-priority patent/GB9903538D0/en
Application filed by Individual filed Critical Individual
Priority claimed from PCT/GB1999/003181 external-priority patent/WO2000017371A1/fr
Publication of CA2343324A1 publication Critical patent/CA2343324A1/fr
Abandoned legal-status Critical Current

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne un polynucléotide comprenant au moins deux répétitions d'un élément de réponse hypoxique (HRE), les sites de liaison consensus au facteur inductible par hypoxie dans chacune de ces deux répétitions étant séparés par un espaceur d'au moins 20 nucléotides contigus. Cette invention concerne également un polynucléotide comprenant au moins trois répétitions d'un élément de réponse hypoxique (HRE) de phosphoglycérokinase (PGK), lié de manière fonctionnelle à un promoteur SV40 ou à un promoteur MLV. Ce polynucléotide peut être lié de manière fonctionnelle à un acide nucléique recherché afin de diriger l'expression de l'acide nucléique recherché (NOI) dans une cellule, dans des conditions hypoxiques.
CA002343324A 1998-09-23 1999-09-22 Produits de recombinaison polynucleotidiques et leurs utilisations Abandoned CA2343324A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
PCT/GB1998/002885 WO1999015684A2 (fr) 1997-09-23 1998-09-23 Methode
GBPCT/GB98/02885 1998-09-23
GB9901906.9 1999-01-28
GBGB9901906.9A GB9901906D0 (en) 1999-01-28 1999-01-28 Polynucleotide constructs and users therof
GB9903538.8 1999-02-16
GBGB9903538.8A GB9903538D0 (en) 1999-02-16 1999-02-16 Polynucleotide constructs and uses therof
PCT/GB1999/003181 WO2000017371A1 (fr) 1998-09-23 1999-09-22 Produits de recombinaison polynucleotidiques et leurs utilisations

Publications (1)

Publication Number Publication Date
CA2343324A1 true CA2343324A1 (fr) 2000-03-30

Family

ID=27269205

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002343324A Abandoned CA2343324A1 (fr) 1998-09-23 1999-09-22 Produits de recombinaison polynucleotidiques et leurs utilisations

Country Status (2)

Country Link
CA (1) CA2343324A1 (fr)
IL (1) IL141829A0 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115029347A (zh) * 2022-05-11 2022-09-09 珠海中科先进技术研究院有限公司 识别和调控肝肾细胞纤维化的分子监测序列、重组质粒、抑制病毒

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115029347A (zh) * 2022-05-11 2022-09-09 珠海中科先进技术研究院有限公司 识别和调控肝肾细胞纤维化的分子监测序列、重组质粒、抑制病毒
CN115029347B (zh) * 2022-05-11 2024-02-20 珠海中科先进技术研究院有限公司 识别和调控肝肾细胞纤维化的分子监测序列、重组质粒、抑制病毒

Also Published As

Publication number Publication date
IL141829A0 (en) 2002-03-10

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Legal Events

Date Code Title Description
FZDE Discontinued