CA2337496A1 - Systemes d'administration et plasmides anti-angiogenese et leurs procedes de preparation et d'utilisation - Google Patents
Systemes d'administration et plasmides anti-angiogenese et leurs procedes de preparation et d'utilisation Download PDFInfo
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- CA2337496A1 CA2337496A1 CA002337496A CA2337496A CA2337496A1 CA 2337496 A1 CA2337496 A1 CA 2337496A1 CA 002337496 A CA002337496 A CA 002337496A CA 2337496 A CA2337496 A CA 2337496A CA 2337496 A1 CA2337496 A1 CA 2337496A1
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
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- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
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Abstract
L'invention concerne des procédés d'administration de gènes et de thérapie génique, ainsi que de nouveaux produits de recombinaison d'acides nucléiques servant à exprimer des agents anti-angiogéniques chez un mammifère, des formulations d'administration incorporant un produit de recombinaison d'acides nucléiques d'expression et des procédés de préparation et d'utilisation de ces produits de recombinaison et de ces formulations. Elle concerne, en particulier, des produits de recombinaison de plasmides permettant d'introduire des agents anti-angiogéniques codant des acides nucléiques dans des cellules, dans le but de moduler une activité tumorale, des procédés d'utilisation de ces produits de recombinaison (y compris une thérapie combinée à d'autres agents, tels que des cytokines, de préférence, IL-12), et des procédés de préparation de ces produits de recombinaison.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9437598P | 1998-07-27 | 1998-07-27 | |
US60/094,375 | 1998-07-27 | ||
PCT/US1999/016388 WO2000006759A2 (fr) | 1998-07-27 | 1999-07-20 | Systemes d'administration et plasmides anti-angiogenese et leurs procedes de preparation et d'utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2337496A1 true CA2337496A1 (fr) | 2000-02-10 |
Family
ID=22244796
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002337496A Abandoned CA2337496A1 (fr) | 1998-07-27 | 1999-07-20 | Systemes d'administration et plasmides anti-angiogenese et leurs procedes de preparation et d'utilisation |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1100941A2 (fr) |
JP (1) | JP2002524036A (fr) |
AU (1) | AU5318299A (fr) |
CA (1) | CA2337496A1 (fr) |
WO (1) | WO2000006759A2 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000047235A2 (fr) * | 1999-02-10 | 2000-08-17 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Méthodes de stimulation de l'angiogenèse |
ES2164011B1 (es) * | 2000-02-25 | 2003-05-16 | Inst Cientifico Tecnol Navarra | Uso combinado de la quimiocina ip-10 y la interleucina-12 en la preparacion de composiciones para el tratamiento de tumores malignos. |
AU8591901A (en) | 2000-09-05 | 2002-03-22 | Karolinska Innovations Ab | Materials and methods relating to endothelial cell growth inhibitors |
CN1531422A (zh) * | 2000-10-20 | 2004-09-22 | 治疗局部缺血的基因转移配方及方法 | |
AU2003222427B8 (en) | 2000-11-17 | 2010-04-29 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
US8071740B2 (en) | 2000-11-17 | 2011-12-06 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
US7067649B2 (en) * | 2000-11-17 | 2006-06-27 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
US20100282634A1 (en) * | 2000-11-17 | 2010-11-11 | Dror Harats | Promoters Exhibiting Endothelial Cell Specificity and Methods of Using Same for Regulation of Angiogenesis |
US8039261B2 (en) | 2000-11-17 | 2011-10-18 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
EP2223932A1 (fr) | 2001-10-19 | 2010-09-01 | Vascular Biogenics Ltd. | Constructions de polynucleotides, compositions pharmaceutiques et procédés de régulation négative de l'angiogenèse et de thérapie anticancereuse |
WO2003106636A2 (fr) * | 2002-06-14 | 2003-12-24 | Mirus Corporation | Nouveaux procedes d'apport de polynucleotides dans des cellules |
EP3608426A1 (fr) * | 2018-08-10 | 2020-02-12 | Pantherna Therapeutics GmbH | Construction d'acide nucléique de recombinaison |
ES2970185T3 (es) * | 2018-08-10 | 2024-05-27 | Pantherna Therapeutics Gmbh | Constructo de ácido nucleico recombinante |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9506466D0 (en) * | 1994-08-26 | 1995-05-17 | Prolifix Ltd | Cell cycle regulated repressor and dna element |
KR19990066981A (ko) * | 1995-10-23 | 1999-08-16 | 윌리엄 뉴우 | 치료용 맥관형성억제 조성물 및 방법 |
US6080728A (en) * | 1996-07-16 | 2000-06-27 | Mixson; A. James | Carrier: DNA complexes containing DNA encoding anti-angiogenic peptides and their use in gene therapy |
DE69736692T2 (de) * | 1996-07-16 | 2007-06-14 | Archibald James Mixson | Kationisches Vehikel: DNS Komplexe und ihre Verwendung in Gentherapie |
-
1999
- 1999-07-20 JP JP2000562541A patent/JP2002524036A/ja active Pending
- 1999-07-20 EP EP99938769A patent/EP1100941A2/fr not_active Withdrawn
- 1999-07-20 CA CA002337496A patent/CA2337496A1/fr not_active Abandoned
- 1999-07-20 AU AU53182/99A patent/AU5318299A/en not_active Abandoned
- 1999-07-20 WO PCT/US1999/016388 patent/WO2000006759A2/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1100941A2 (fr) | 2001-05-23 |
JP2002524036A (ja) | 2002-08-06 |
WO2000006759A3 (fr) | 2000-06-22 |
WO2000006759A2 (fr) | 2000-02-10 |
AU5318299A (en) | 2000-02-21 |
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