CA2337495A1 - Melanocortin-4 receptor gene and use as a genetic marker for fat content, weight gain, and/or feed consumption of animals - Google Patents

Melanocortin-4 receptor gene and use as a genetic marker for fat content, weight gain, and/or feed consumption of animals Download PDF

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Publication number
CA2337495A1
CA2337495A1 CA002337495A CA2337495A CA2337495A1 CA 2337495 A1 CA2337495 A1 CA 2337495A1 CA 002337495 A CA002337495 A CA 002337495A CA 2337495 A CA2337495 A CA 2337495A CA 2337495 A1 CA2337495 A1 CA 2337495A1
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CA
Canada
Prior art keywords
fat content
feed consumption
animals
melanocortin
genetic marker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002337495A
Other languages
French (fr)
Other versions
CA2337495C (en
Inventor
Max F. Rothschild
Niels J. Larsen
Kwan Suk Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Iowa State University Research Foundation ISURF
Original Assignee
Iowa State University Research Foundation
Max F. Rothschild
Niels J. Larsen
Kwan Suk Kim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Iowa State University Research Foundation, Max F. Rothschild, Niels J. Larsen, Kwan Suk Kim filed Critical Iowa State University Research Foundation
Publication of CA2337495A1 publication Critical patent/CA2337495A1/en
Application granted granted Critical
Publication of CA2337495C publication Critical patent/CA2337495C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/124—Animal traits, i.e. production traits, including athletic performance or the like
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Genetic markers in the porcine melanocortin-4 receptor (MC4R) gene are disclosed which are associated with fat content, growth rate, and feed consumption. Further, novel sequence data from regions of the gene are disclosed which may be used in a PCR test to screen for the presence of the marker. The genetic marker may be used to screen animals for breeding purposes which have the desired traits regarding fat content, growth rate, and feed consumption. Kits which take advantage of the PCR test are also disclosed.
CA002337495A 1998-07-27 1999-07-26 Melanocortin-4 receptor gene and use as a genetic marker for fat content, weight gain, and/or feed consumption of animals Expired - Lifetime CA2337495C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9428798P 1998-07-27 1998-07-27
US60/094,287 1998-07-27
US11618699P 1999-01-15 1999-01-15
US60/116,186 1999-01-15
PCT/US1999/016862 WO2000006777A2 (en) 1998-07-27 1999-07-26 Melanocortin-4 receptor gene and use as a genetic marker for fat content, weight gain, and/or feed consumption of animals

Publications (2)

Publication Number Publication Date
CA2337495A1 true CA2337495A1 (en) 2000-02-10
CA2337495C CA2337495C (en) 2008-03-18

Family

ID=26788709

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002337495A Expired - Lifetime CA2337495C (en) 1998-07-27 1999-07-26 Melanocortin-4 receptor gene and use as a genetic marker for fat content, weight gain, and/or feed consumption of animals

Country Status (10)

Country Link
EP (1) EP1100970A2 (en)
JP (1) JP3790102B2 (en)
CN (1) CN1193102C (en)
AU (1) AU758179B2 (en)
BR (1) BR9912460A (en)
CA (1) CA2337495C (en)
HU (1) HUP0102715A3 (en)
MX (1) MXPA01001100A (en)
PL (1) PL346223A1 (en)
WO (1) WO2000006777A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002064091A2 (en) 2001-02-13 2002-08-22 Palatin Technologies, Inc. Melanocortin metallopeptides for treatment of sexual dysfunction
US6803190B1 (en) 1998-07-27 2004-10-12 Iowa State University Research Foundation, Inc. Melanocortin-4 receptor gene and use as a genetic marker for fat content, weight gain, and/or feed consumption of animals
WO2001075161A2 (en) * 2000-03-30 2001-10-11 Iowa State University Research Foundation Genetic markers for improved meat characteristics in animals
WO2001079222A2 (en) * 2000-04-12 2001-10-25 Genaissance Pharmaceuticals, Inc. Haplotypes of the mc4r gene
US20030032791A1 (en) * 2000-06-26 2003-02-13 Alan Robertson Scott Novel melanocortin-4 receptor sequences and screening assays to identify compounds useful in regulating animal appetite and metabolic rate
KR100427645B1 (en) * 2001-07-24 2004-04-28 한국생명공학연구원 Human melanocortin-4 receptor specific antibody and the preparation method thereof
CA2387003A1 (en) * 2002-05-21 2003-11-21 984012 Alberta Ltd. Method for improving efficiencies in livestock production
US20050260603A1 (en) 2002-12-31 2005-11-24 Mmi Genomics, Inc. Compositions for inferring bovine traits
PL2286825T3 (en) * 2005-07-08 2017-06-30 Ipsen Pharma Melanocortin receptor ligands
CN100591692C (en) * 2007-08-13 2010-02-24 中国农业科学院北京畜牧兽医研究所 Pig fat deposition related protein and encoding genes and use thereof
WO2009073397A1 (en) 2007-11-29 2009-06-11 Monsanto Technology Llc Meat products with increased levels of beneficial fatty acids
CN103923997B (en) * 2014-04-21 2016-09-07 广西壮族自治区水牛研究所 The clone of buffalo milk production trait MC4R gene and the application as molecular labeling

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5940198A (en) * 1995-12-22 1999-08-17 U.S. Philips Corporation Optical unit for synchronizing clock signals
US5932779A (en) * 1996-06-10 1999-08-03 Millennium Pharmaceuticals, Inc. Screening methods for compounds useful in the regulation of body weight

Also Published As

Publication number Publication date
CA2337495C (en) 2008-03-18
CN1328602A (en) 2001-12-26
BR9912460A (en) 2002-02-13
CN1193102C (en) 2005-03-16
EP1100970A2 (en) 2001-05-23
MXPA01001100A (en) 2002-08-20
WO2000006777A3 (en) 2000-05-11
AU5230199A (en) 2000-02-21
HUP0102715A2 (en) 2002-09-28
WO2000006777A2 (en) 2000-02-10
JP2002521068A (en) 2002-07-16
AU758179B2 (en) 2003-03-20
PL346223A1 (en) 2002-01-28
HUP0102715A3 (en) 2004-10-28
JP3790102B2 (en) 2006-06-28

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Effective date: 20190726