CA2329694A1 - Polypeptide du domaine de kunitz, materiaux et procedes pour le realiser - Google Patents

Polypeptide du domaine de kunitz, materiaux et procedes pour le realiser Download PDF

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Publication number
CA2329694A1
CA2329694A1 CA002329694A CA2329694A CA2329694A1 CA 2329694 A1 CA2329694 A1 CA 2329694A1 CA 002329694 A CA002329694 A CA 002329694A CA 2329694 A CA2329694 A CA 2329694A CA 2329694 A1 CA2329694 A1 CA 2329694A1
Authority
CA
Canada
Prior art keywords
gly
seq
glu
protein
pro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002329694A
Other languages
English (en)
Inventor
Darrell C. Conklin
Donald C. Foster
Zeren Gao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zymogenetics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2329694A1 publication Critical patent/CA2329694A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors

Abstract

La présente invention concerne des inhibiteurs de protéinases comprenant un domaine de Künitz. Le domaine de Künitz comprend une séquence de résidus d'acides aminés représentés par le SEQ ID NO:5, la séquence étant pour 90 % identique au SEQ ID NO:2. L'invention concerne également, d'une part des procédés permettant de réaliser ces inhibiteurs de protéinases, mais aussi des vecteurs d'expression ainsi que des cellules de culture convenant dans le cadre de ces procédés. Ces inhibiteurs de protéinases, qui conviennent comme composantes du milieu de culture cellulaire, conviennent également pour la purification de protéines, et pour certaines applications thérapeutiques et diagnostiques.
CA002329694A 1998-05-28 1999-05-26 Polypeptide du domaine de kunitz, materiaux et procedes pour le realiser Abandoned CA2329694A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8625398A 1998-05-28 1998-05-28
US09/086,253 1998-05-28
PCT/US1999/011628 WO1999061615A1 (fr) 1998-05-28 1999-05-26 Polypeptide du domaine de kunitz, materiaux et procedes pour le realiser

Publications (1)

Publication Number Publication Date
CA2329694A1 true CA2329694A1 (fr) 1999-12-02

Family

ID=22197292

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002329694A Abandoned CA2329694A1 (fr) 1998-05-28 1999-05-26 Polypeptide du domaine de kunitz, materiaux et procedes pour le realiser

Country Status (5)

Country Link
EP (1) EP1082430A1 (fr)
JP (1) JP2002516102A (fr)
AU (1) AU4207499A (fr)
CA (1) CA2329694A1 (fr)
WO (1) WO1999061615A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001046230A2 (fr) * 1999-12-22 2001-06-28 Zymogenetics, Inc. Polypeptide zkun11 a domaine de kunitz
US6544760B2 (en) 1999-12-22 2003-04-08 Zymogenetics, Inc. Kunitz domain polypeptide Zkun11
AU2001241817A1 (en) * 2000-02-29 2001-09-12 Zymogenetics Inc. Kunitz domain polypeptide zkun8
CN1276974C (zh) * 2000-07-27 2006-09-27 希龙公司 Gsk3多肽
GB0521958D0 (en) * 2005-10-27 2005-12-07 Ares Trading Sa vWFA, collagen and kunitz domain containing protein

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0739355T3 (da) * 1994-01-11 2005-01-24 Dyax Corp Kallikrein-inhiberende "Kunitz-domæne"-proteiner og analoger deraf
EP0827539A2 (fr) * 1995-05-08 1998-03-11 Scios Inc. Peptides inhibiteurs de proteases de type kunitz

Also Published As

Publication number Publication date
EP1082430A1 (fr) 2001-03-14
AU4207499A (en) 1999-12-13
WO1999061615A1 (fr) 1999-12-02
JP2002516102A (ja) 2002-06-04

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued