CA2327395A1 - New imidazotriazolopyrimidines, processes for preparing them and their use as pharmaceutical compositions - Google Patents

New imidazotriazolopyrimidines, processes for preparing them and their use as pharmaceutical compositions Download PDF

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Publication number
CA2327395A1
CA2327395A1 CA002327395A CA2327395A CA2327395A1 CA 2327395 A1 CA2327395 A1 CA 2327395A1 CA 002327395 A CA002327395 A CA 002327395A CA 2327395 A CA2327395 A CA 2327395A CA 2327395 A1 CA2327395 A1 CA 2327395A1
Authority
CA
Canada
Prior art keywords
preparing
processes
new
pharmaceutical compositions
imidazotriazolopyrimidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002327395A
Other languages
French (fr)
Other versions
CA2327395C (en
Inventor
Stefan Blech
Adrian Carter
Wolfram Gaida
Matthias Hoffmann
Ulrike Kuefner-Muehl
Christopher John Montague Meade
Gerald Pohl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2327395A1 publication Critical patent/CA2327395A1/en
Application granted granted Critical
Publication of CA2327395C publication Critical patent/CA2327395C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention relates to new imidazotriazolopyrimidine derivatives of general formula (I), processes for preparing them and their use as pharmaceutical compositions
CA002327395A 1998-06-16 1999-06-11 New imidazotriazolopyrimidines, processes for preparing them and their use as pharmaceutical compositions Expired - Fee Related CA2327395C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19826843.2 1998-06-16
DE19826843A DE19826843A1 (en) 1998-06-16 1998-06-16 Novel imidazotriazolopyrimidines, process for their preparation and their use as medicaments
PCT/EP1999/004017 WO1999065912A1 (en) 1998-06-16 1999-06-11 Imidazotriazolopyrimidines used as a drug having an adenosine antagonist activity

Publications (2)

Publication Number Publication Date
CA2327395A1 true CA2327395A1 (en) 1999-12-23
CA2327395C CA2327395C (en) 2008-05-13

Family

ID=7871072

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002327395A Expired - Fee Related CA2327395C (en) 1998-06-16 1999-06-11 New imidazotriazolopyrimidines, processes for preparing them and their use as pharmaceutical compositions

Country Status (9)

Country Link
EP (1) EP1087973B1 (en)
JP (1) JP4567883B2 (en)
AT (1) ATE230748T1 (en)
AU (1) AU4511299A (en)
CA (1) CA2327395C (en)
DE (2) DE19826843A1 (en)
DK (1) DK1087973T3 (en)
ES (1) ES2186369T3 (en)
WO (1) WO1999065912A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19858331A1 (en) * 1998-12-17 2000-06-21 Boehringer Ingelheim Pharma Tricyclic nitrogen heterocycles as PDE IV inhibitors
US6417190B1 (en) 1998-12-17 2002-07-09 Boehringer Ingelheim Pharma Kg Tricyclic nitrogen heterocycles as PDE IV inhibitors
AR044041A1 (en) * 2003-04-23 2005-08-24 Schering Corp ANTAGONISTS OF THE A2A RECEIVER OF 2-ALQUINIL- AND 2-ALQUENIL-PIRAZOLO- [4,3-E] -1,2,4-TRIAZOLO- [1,5-C] -PIRIMIDINA ADENOSINA
US7071333B2 (en) 2003-07-30 2006-07-04 Bristol-Myers Squibb Company Triazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same
AU2019205661B2 (en) * 2018-01-04 2022-06-30 Impetis Biosciences Ltd. Tricyclic compounds, compositions and medicinal applications thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06104666B2 (en) * 1986-09-30 1994-12-21 チバ―ガイギー アクチェンゲゼルシャフト 2-Substituted-e-fused- [1,2,4] triazolo [1,5-c] pyrimidines and pharmaceutical compositions containing the same
DE19629378A1 (en) * 1996-07-20 1998-01-29 Boehringer Ingelheim Kg New triazolopurines, process for their preparation and their use as medicaments

Also Published As

Publication number Publication date
ES2186369T3 (en) 2003-05-01
JP4567883B2 (en) 2010-10-20
AU4511299A (en) 2000-01-05
ATE230748T1 (en) 2003-01-15
JP2002518396A (en) 2002-06-25
WO1999065912A1 (en) 1999-12-23
EP1087973A1 (en) 2001-04-04
DK1087973T3 (en) 2003-02-24
DE19826843A1 (en) 1999-12-23
DE59903977D1 (en) 2003-02-13
EP1087973B1 (en) 2003-01-08
CA2327395C (en) 2008-05-13

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20130611