CA2325583A1 - Automated staining apparatus - Google Patents
Automated staining apparatus Download PDFInfo
- Publication number
- CA2325583A1 CA2325583A1 CA002325583A CA2325583A CA2325583A1 CA 2325583 A1 CA2325583 A1 CA 2325583A1 CA 002325583 A CA002325583 A CA 002325583A CA 2325583 A CA2325583 A CA 2325583A CA 2325583 A1 CA2325583 A1 CA 2325583A1
- Authority
- CA
- Canada
- Prior art keywords
- tip
- reagent
- head
- slide
- microscope slide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000010186 staining Methods 0.000 title claims abstract description 36
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 247
- 239000007788 liquid Substances 0.000 claims abstract description 68
- 238000012545 processing Methods 0.000 claims abstract description 14
- 230000033001 locomotion Effects 0.000 claims description 36
- 239000012530 fluid Substances 0.000 claims description 8
- 230000000717 retained effect Effects 0.000 claims description 8
- 239000000872 buffer Substances 0.000 description 35
- 238000000034 method Methods 0.000 description 32
- 239000000243 solution Substances 0.000 description 21
- 210000001519 tissue Anatomy 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 239000010408 film Substances 0.000 description 11
- 230000006870 function Effects 0.000 description 11
- 238000002360 preparation method Methods 0.000 description 11
- 230000008569 process Effects 0.000 description 9
- 238000012864 cross contamination Methods 0.000 description 8
- 239000006193 liquid solution Substances 0.000 description 8
- 230000007480 spreading Effects 0.000 description 8
- 238000003892 spreading Methods 0.000 description 8
- 238000011534 incubation Methods 0.000 description 7
- 239000004094 surface-active agent Substances 0.000 description 7
- 230000008901 benefit Effects 0.000 description 6
- 238000007664 blowing Methods 0.000 description 6
- 238000009826 distribution Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 229920003023 plastic Polymers 0.000 description 5
- 239000004033 plastic Substances 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 238000005507 spraying Methods 0.000 description 4
- 239000012128 staining reagent Substances 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 3
- 238000012744 immunostaining Methods 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000010409 thin film Substances 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 1
- 241000183290 Scleropages leichardti Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000010936 aqueous wash Methods 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 210000005224 forefinger Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000002853 nucleic acid probe Substances 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000004801 process automation Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229920001935 styrene-ethylene-butadiene-styrene Polymers 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N1/312—Apparatus therefor for samples mounted on planar substrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N2001/317—Apparatus therefor spraying liquids onto surfaces
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
- G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Microscoopes, Condenser (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1998/005919 WO1999049295A1 (en) | 1998-03-24 | 1998-03-24 | Automated staining apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2325583A1 true CA2325583A1 (en) | 1999-09-30 |
Family
ID=22266681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002325583A Abandoned CA2325583A1 (en) | 1998-03-24 | 1998-03-24 | Automated staining apparatus |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1066502A1 (https=) |
| JP (1) | JP2002507738A (https=) |
| AU (1) | AU762808B2 (https=) |
| CA (1) | CA2325583A1 (https=) |
| WO (1) | WO1999049295A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119043850A (zh) * | 2024-10-31 | 2024-11-29 | 四川省畜牧科学研究院 | 一种组织染色机 |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6572824B1 (en) | 1998-09-18 | 2003-06-03 | Cytyc Corporation | Method and apparatus for preparing cytological specimens |
| US6562299B1 (en) | 1998-09-18 | 2003-05-13 | Cytyc Corporation | Method and apparatus for preparing cytological specimens |
| US20030059347A1 (en) | 1998-09-18 | 2003-03-27 | Roy A. Ostgaard | Sample vial for use in preparing cytological specimen |
| US6746851B1 (en) * | 2000-01-14 | 2004-06-08 | Lab Vision Corporation | Method for automated staining of specimen slides |
| DE10010140A1 (de) * | 2000-03-03 | 2001-09-13 | Leica Microsystems | Vorrichtung zur vorzugsweise automatischen Handhabung und/oder Bearbeitung von Objekten |
| ATE335196T1 (de) * | 2000-03-08 | 2006-08-15 | Cytyc Corp | Verfahren und vorrichtung zur vorbereitung von zellproben |
| AU2006201456B2 (en) * | 2000-03-08 | 2008-05-08 | Cytyc Corporation | Method and apparatus for preparing cytological specimens |
| WO2002013967A2 (en) * | 2000-08-11 | 2002-02-21 | Incyte Genomics, Inc. | Microarray alignment mechanism |
| CN105258988A (zh) * | 2002-06-20 | 2016-01-20 | 徕卡病理系统墨尔本控股有限公司 | 带有排放机构的生物反应装置 |
| AU2003901871A0 (en) * | 2003-03-31 | 2003-05-08 | Vision Biosystems Limited | A method and apparatus for fluid dispensation, preparation and dilation |
| AU2003289053A1 (en) * | 2002-12-12 | 2004-06-30 | The New Industry Research Organization | Method of rapidly staining microorganism and apparatus therefor |
| US7648678B2 (en) | 2002-12-20 | 2010-01-19 | Dako Denmark A/S | Method and system for pretreatment of tissue slides |
| JP2007526479A (ja) * | 2004-03-02 | 2007-09-13 | ダコ デンマーク アクティーゼルスカブ | 生物学的染色装置のための試薬送達システム、分配デバイスおよび容器 |
| US8459509B2 (en) | 2006-05-25 | 2013-06-11 | Sakura Finetek U.S.A., Inc. | Fluid dispensing apparatus |
| GR1005835B (el) * | 2006-09-20 | 2008-03-04 | Φλορεντς Καλουδε | Συσκευη επιστρωσης αντικειμενοφορων πλακων σε ρυθμιζομενες συνθηκες υγρασιας και θερμοκρασιας για τη μελετη χρωμοσωματων στο μικροσκοπιο |
| JP5598766B2 (ja) * | 2008-04-10 | 2014-10-01 | デナトール アクティエボラグ | 生体試料を保管し調整する装置 |
| JP2011524527A (ja) * | 2008-06-16 | 2011-09-01 | ライカ バイオシステムズ メルボルン ピーティーワイ エルティーディー | 染色機器及び方法における改良 |
| WO2010078177A1 (en) * | 2008-12-31 | 2010-07-08 | Ventana Medical Systems, Inc. | Robotic pipette system |
| DE102009015596A1 (de) | 2009-03-30 | 2010-10-21 | Dcs Innovative Diagnostik-Systeme Dr. Christian Sartori Gmbh & Co. Kg | Verfahren und Vorrichtung zur Behandlung von trägerfixiertem Material |
| US8067241B2 (en) * | 2009-08-26 | 2011-11-29 | General Electric Company | Method and apparatus for antigen retrieval process |
| DE102010010975B4 (de) | 2009-09-14 | 2012-05-31 | Dcs Innovative Diagnostik-Systeme Dr. Christian Sartori Gmbh & Co. Kg | Objektträgerhalter |
| WO2014102160A1 (en) * | 2012-12-26 | 2014-07-03 | Ventana Medical Systems, Inc. | Automated specimen processing systems and methods of using the same |
| US10746752B2 (en) | 2009-11-13 | 2020-08-18 | Ventana Medical Systems, Inc. | Opposables and automated specimen processing systems with opposables |
| JP5611363B2 (ja) | 2009-11-13 | 2014-10-22 | ベンタナ メディカル システムズ， インコーポレイテッド | 調整可能な体積を収容する薄膜処理装置 |
| US9498791B2 (en) | 2009-11-13 | 2016-11-22 | Ventana Medical Systems, Inc. | Opposables and automated specimen processing systems with opposables |
| FR2957672B1 (fr) * | 2010-03-22 | 2013-03-15 | Novacyt | Procede automatique et automate de preparation et d'analyse d'une pluralite de suspensions cellulaires |
| DE102010064694B3 (de) * | 2010-12-07 | 2020-02-13 | Leica Biosystems Nussloch Gmbh | Haltevorrichtung zur Aufnahme von Objektträgern |
| US8752732B2 (en) | 2011-02-01 | 2014-06-17 | Sakura Finetek U.S.A., Inc. | Fluid dispensing system |
| US8932543B2 (en) | 2011-09-21 | 2015-01-13 | Sakura Finetek U.S.A., Inc. | Automated staining system and reaction chamber |
| US8580568B2 (en) * | 2011-09-21 | 2013-11-12 | Sakura Finetek U.S.A., Inc. | Traceability for automated staining system |
| US11274998B2 (en) | 2012-12-26 | 2022-03-15 | Ventana Medical Systems, Inc. | Specimen processing systems and methods for holding slides |
| US9989448B2 (en) | 2012-12-26 | 2018-06-05 | Ventana Medical Systems, Inc. | Specimen processing systems and methods for holding slides |
| HU230739B1 (hu) | 2013-02-28 | 2018-01-29 | 3Dhistech Kft. | Berendezés és eljárás tárgylemezek automatikus festésére, fedésére, digitalizálására integrált tárgylemez festő-fedő-digitalizáló automata berendezés segítségével |
| USD728120S1 (en) | 2013-03-15 | 2015-04-28 | Ventana Medical Systems, Inc. | Arcuate member for moving liquids along a microscope slide |
| JP6678588B2 (ja) | 2014-09-22 | 2020-04-08 | 株式会社ニチレイバイオサイエンス | 自動組織染色装置及び自動組織染色方法 |
| US11474007B2 (en) * | 2019-01-04 | 2022-10-18 | Funai Electric Co., Ltd. | Digital dispense system |
| HU231400B1 (hu) | 2021-01-21 | 2023-06-28 | 3Dhistech Kft. | Berendezés mikroszkóp tárgylemez mozgatására |
| KR102581395B1 (ko) * | 2022-10-26 | 2023-09-21 | 주식회사 큐리오시스 | 슬라이드 트레이의 정상 장착 확인 장치 및 방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE788877A (fr) * | 1971-09-17 | 1973-01-02 | Vickers Ltd | Agitation d'echantillons liquides pour l'obtention de melanges homogenes |
| US5595707A (en) * | 1990-03-02 | 1997-01-21 | Ventana Medical Systems, Inc. | Automated biological reaction apparatus |
| US5425918A (en) * | 1990-07-18 | 1995-06-20 | Australian Biomedical Corporation | Apparatus for automatic tissue staining for immunohistochemistry |
| US5439649A (en) * | 1993-09-29 | 1995-08-08 | Biogenex Laboratories | Automated staining apparatus |
-
1998
- 1998-03-24 CA CA002325583A patent/CA2325583A1/en not_active Abandoned
- 1998-03-24 WO PCT/US1998/005919 patent/WO1999049295A1/en not_active Ceased
- 1998-03-24 AU AU69417/98A patent/AU762808B2/en not_active Ceased
- 1998-03-24 EP EP98915168A patent/EP1066502A1/en not_active Withdrawn
- 1998-03-24 JP JP2000538216A patent/JP2002507738A/ja not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119043850A (zh) * | 2024-10-31 | 2024-11-29 | 四川省畜牧科学研究院 | 一种组织染色机 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1066502A1 (en) | 2001-01-10 |
| AU6941798A (en) | 1999-10-18 |
| WO1999049295A1 (en) | 1999-09-30 |
| AU762808B2 (en) | 2003-07-03 |
| JP2002507738A (ja) | 2002-03-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |