CA2322843A1 - Genes et proteines d'origine humaine exprimes dans des conditions d'hypoxie, et utilisations de ceux-ci - Google Patents

Genes et proteines d'origine humaine exprimes dans des conditions d'hypoxie, et utilisations de ceux-ci Download PDF

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Publication number
CA2322843A1
CA2322843A1 CA002322843A CA2322843A CA2322843A1 CA 2322843 A1 CA2322843 A1 CA 2322843A1 CA 002322843 A CA002322843 A CA 002322843A CA 2322843 A CA2322843 A CA 2322843A CA 2322843 A1 CA2322843 A1 CA 2322843A1
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CA
Canada
Prior art keywords
hypoxia
protein
proteins
tissue
animal
Prior art date
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Abandoned
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CA002322843A
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English (en)
Inventor
Nicholas C. Denko
Amato J. Giaccia
Christopher J. Green
Keith R. Laderoute
Cornelia Schindler
Albert Ching-Wei Koong
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SRI International Inc
Leland Stanford Junior University
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Individual
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Publication date
Application filed by Individual filed Critical Individual
Publication of CA2322843A1 publication Critical patent/CA2322843A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne les séquences polynucléotidiques et polypeptidiques de deux nouveaux gènes humains exprimés dans des conditions d'hypoxie, HIG1 et HIG2. De plus, il a été établi que certains gènes connus peuvent être exprimés dans des conditions d'hypoxie. Ces gènes comprennent notamment l'annexine V, la lipocortine 2, hnRNP A1, l'auto-antigène Ku, la phosphoribosylpyrophosphate synthétase, l'acétoacétylCoA thiolase, la protéine L7 ribosomale, le facteur de croissance de fibroblastes 3, le ligand du récepteur d'EPH, l'inhibiteur 1 des activateurs du plasminogène, le facteur d'inhibition de migration des macrophages, le récepteur de la fibronectine, la lysyl hydroxylase 2, l'endothéline 2, le gène 1 de translocation de cellules B, la protéine réagissant à la tunicamycine et à son agent de réduction, la kinase 1 de type CDC, la quiescine, la protéine 45 exprimée dans des conditions de dommages à l'ADN d'arrêt de croissance, DEC1, la protéine liée au récepteur de lipoprotéine faible densité, l'homologue du gène de poils de hamster, l'adipophiline, la cyclo-oxygénase 1, la fructose bisphosphatase, le transporteur de la créatine, la protéine de fixation des acides gras, la lactate déshydrogénase, la protéine tueuse par interaction avec Bcl-2, Nip3L/Nix et Pim-1. L'invention concerne des arrangements de polynucléotides et de polypeptides qui contiennent les séquences des gènes ou des protéines exprimés dans des conditions d'hypoxie, ou des anticorps qui se lient de manière spécifique à ces protéines. L'invention concerne également des procédés d'utilisation des séquences des gènes et des protéines exprimés dans des conditions d'hypoxie, et des arrangements de ceux-ci, à des fins de diagnostic et de traitement d'états pathologiques liés à l'hypoxie tels que le cancer et l'ischémie.
CA002322843A 1998-03-27 1999-03-29 Genes et proteines d'origine humaine exprimes dans des conditions d'hypoxie, et utilisations de ceux-ci Abandoned CA2322843A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4971998A 1998-03-27 1998-03-27
US09/049,719 1998-03-27
PCT/US1999/006860 WO1999048916A2 (fr) 1998-03-27 1999-03-29 Genes et proteines d'origine humaine exprimes dans des conditions d'hypoxie, et utilisations de ceux-ci

Publications (1)

Publication Number Publication Date
CA2322843A1 true CA2322843A1 (fr) 1999-09-30

Family

ID=21961323

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002322843A Abandoned CA2322843A1 (fr) 1998-03-27 1999-03-29 Genes et proteines d'origine humaine exprimes dans des conditions d'hypoxie, et utilisations de ceux-ci

Country Status (5)

Country Link
EP (1) EP1064378A2 (fr)
JP (1) JP2002507405A (fr)
AU (1) AU3455599A (fr)
CA (1) CA2322843A1 (fr)
WO (1) WO1999048916A2 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7748200A (en) * 1999-09-30 2001-04-30 Varian Associates, Inc. Hypoxia-related human genes, proteins, and uses thereof
WO2001062965A2 (fr) * 2000-02-22 2001-08-30 Oxford Biomedica (Uk) Limited Procede d'analyse par expression differentielle
US7678391B2 (en) 2000-04-26 2010-03-16 Queen's University At Kingston Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype
GB0020067D0 (en) * 2000-08-16 2000-10-04 Univ Glasgow Treatment of cerebral ischaemic damage
DE60124927T2 (de) * 2000-09-01 2007-09-20 Philadelphia Health And Education Corp. Verfahren und zusammensetzungen zur inhibition der angiogenese
US7160858B2 (en) 2000-09-01 2007-01-09 Philadelphia, Health And Education Corporation Methods and compositions for inhibiting angiogenesis
GB0109008D0 (en) * 2001-04-10 2001-05-30 Oxford Biomedica Ltd Novel genes
EP1379266B1 (fr) 2001-02-21 2007-04-18 SurroMed, Inc. Annexines modifiees et prevention de la thrombose
US7635680B2 (en) 2001-02-21 2009-12-22 Alavita Pharmaceuticals, Inc. Attenuation of reperfusion injury
US7635676B2 (en) 2001-02-21 2009-12-22 Alavita Pharmaccuticals, Inc. Modified annexin proteins and methods for their use in organ transplantation
US7645739B2 (en) 2001-02-21 2010-01-12 Alavita Pharmaceuticals, Inc. Modified annexin compositions and methods of using same
AU2003225495B2 (en) 2002-04-05 2009-01-15 Roche Innovation Center Copenhagen A/S Oligomeric compounds for the modulation HIF-1alpha expression
US20040110157A1 (en) * 2002-12-10 2004-06-10 Isis Pharmaceuticals Inc. Modulation of acetyl-CoA acetyltransferase 2 expression
US7144999B2 (en) 2002-11-23 2006-12-05 Isis Pharmaceuticals, Inc. Modulation of hypoxia-inducible factor 1 alpha expression
US7618947B2 (en) 2004-08-25 2009-11-17 Isis Pharmaceuticals, Inc. Modulation of HIF-1 beta expression
WO2006032148A1 (fr) * 2004-09-24 2006-03-30 Mount Sinai Hospital Polynucleotides et polypeptides associes a la mort cellulaire des trophoblastes, a la differentiation, a l'invasion et/ou a la fusion ou au renouvellement des cellules
DK1833840T3 (da) 2004-11-09 2010-10-18 Santaris Pharma As Micromirs
US9447138B2 (en) 2004-11-09 2016-09-20 Roche Innovation Center Copenhagen A/S Potent LNA oligonucleotides for the inhibition of HIF-1a expression
US8691956B2 (en) 2009-09-30 2014-04-08 Ishihara Sangyo Kaisha, Ltd. Monoclonal antibody against human HIG-1 polypeptide
CA2817851A1 (fr) * 2010-11-12 2012-05-18 The Johns Hopkins University Complexe de proteine/peptide lie a l'albumine en tant que biomarqueur pour une maladie
CA3012985A1 (fr) 2015-01-27 2016-08-04 Kardiatonos, Inc. Biomarqueurs de maladies vasculaires
WO2023214183A2 (fr) 2022-05-06 2023-11-09 Antibody Analytics Limited Systèmes de proximité induits chimiquement

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4591570A (en) * 1983-02-02 1986-05-27 Centocor, Inc. Matrix of antibody-coated spots for determination of antigens
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6040138A (en) * 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5882914A (en) * 1995-06-06 1999-03-16 The Johns Hopkins University School Of Medicine Nucleic acids encoding the hypoxia inducible factor-1
WO1997000956A1 (fr) * 1995-06-20 1997-01-09 Trustees Of Boston University Molecules d'adherence reagissant a l'hypoxemie, anticorps specifiques et leurs utilisations
CA2191903A1 (fr) * 1995-12-20 1997-06-21 Jun Ikeda Proteines de stress

Also Published As

Publication number Publication date
WO1999048916A2 (fr) 1999-09-30
WO1999048916A3 (fr) 2000-01-20
WO1999048916A8 (fr) 2008-05-08
JP2002507405A (ja) 2002-03-12
EP1064378A2 (fr) 2001-01-03
AU3455599A (en) 1999-10-18

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