CA2319148A1 - Procedes d'identification de cibles therapeutiques - Google Patents

Procedes d'identification de cibles therapeutiques Download PDF

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Publication number
CA2319148A1
CA2319148A1 CA002319148A CA2319148A CA2319148A1 CA 2319148 A1 CA2319148 A1 CA 2319148A1 CA 002319148 A CA002319148 A CA 002319148A CA 2319148 A CA2319148 A CA 2319148A CA 2319148 A1 CA2319148 A1 CA 2319148A1
Authority
CA
Canada
Prior art keywords
cell
cells
sample
neoplastic
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002319148A
Other languages
English (en)
Inventor
Bruce L. Roberts
Srinivas Shankara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2319148A1 publication Critical patent/CA2319148A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1072—Differential gene expression library synthesis, e.g. subtracted libraries, differential screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne de manière générale un procédé de corrélation du phénotype d'une cellule avec le génotype fonctionnel de celle-ci, à savoir la constellation de séquences exprimés dans cette cellule. En outre, l'invention concerne des moyens d'identification de gènes et produits géniques thérapeutiquement appropriés.
CA002319148A 1998-01-26 1999-01-25 Procedes d'identification de cibles therapeutiques Abandoned CA2319148A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US10043698P 1998-01-26 1998-01-26
US60/100,436 1998-01-26
US7785398P 1998-03-13 1998-03-13
US60/077,853 1998-03-13
US10323098P 1998-10-05 1998-10-05
US60/103,230 1998-10-05
PCT/US1999/001463 WO1999037816A1 (fr) 1998-01-26 1999-01-25 Procedes d'identification de cibles therapeutiques

Publications (1)

Publication Number Publication Date
CA2319148A1 true CA2319148A1 (fr) 1999-07-29

Family

ID=27373177

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002319148A Abandoned CA2319148A1 (fr) 1998-01-26 1999-01-25 Procedes d'identification de cibles therapeutiques

Country Status (5)

Country Link
EP (1) EP1053349A4 (fr)
JP (1) JP2002500896A (fr)
AU (1) AU756357B2 (fr)
CA (1) CA2319148A1 (fr)
WO (1) WO1999037816A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1113382A1 (fr) * 1999-12-27 2001-07-04 Applied Research Systems ARS Holding N.V. Procédé d'identification des transcrits géniques avec rendement amélioré du traitement d'erreur
CA2434881A1 (fr) * 2001-02-02 2002-08-15 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Procede d'identification d'acides nucleiques fonctionnels
JP2004287619A (ja) * 2003-03-19 2004-10-14 Ntt Data Corp 疫学情報管理装置、疫学情報管理方法、および、プログラム

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721098A (en) * 1986-01-16 1998-02-24 The Regents Of The University Of California Comparative genomic hybridization
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
DK0834576T3 (da) * 1990-12-06 2002-04-22 Affymetrix Inc A Delaware Corp Påvisning af nukleinsyresekvenser
US5260191A (en) * 1992-01-30 1993-11-09 Agracetus, Inc. Method for diagnosing tumors
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5830645A (en) * 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5695937A (en) * 1995-09-12 1997-12-09 The Johns Hopkins University School Of Medicine Method for serial analysis of gene expression
US5776683A (en) * 1996-07-11 1998-07-07 California Pacific Medical Center Methods for identifying genes amplified in cancer cells

Also Published As

Publication number Publication date
EP1053349A4 (fr) 2004-12-15
AU756357B2 (en) 2003-01-09
JP2002500896A (ja) 2002-01-15
EP1053349A1 (fr) 2000-11-22
AU2339199A (en) 1999-08-09
WO1999037816A1 (fr) 1999-07-29

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued